ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

One of the isoforms of ING1 (p33(ING1) is involved in the modulation of DNA repair.{{cite journal |vauthors=Cheung KJ, Mitchell D, Lin P, Li G |title=The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA |journal=Cancer Res |volume=61 |issue=13 |pages=4974–7 |date=July 2001 |pmid=11431327 |doi= |url=}} It appears that p33(ING1) cooperates with p53 in nucleotide excision repair. Also, proliferating cell nuclear antigen (PCNA) interacts with p33(ING1b) in the elimination of UV-damaged cells through the induction of programmed cell death (apoptosis).{{cite journal |vauthors=Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K |title=UV-induced binding of ING1 to PCNA regulates the induction of apoptosis |journal=J Cell Sci |volume=114 |issue=Pt 19 |pages=3455–62 |date=October 2001 |pmid=11682605 |doi=10.1242/jcs.114.19.3455 |url=}}

ING1 is located near the following genes on Chromosome 13

• CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
• COL4A2: A2 Subunit of type IV collagen
• RAB20: Potential regulator of Connexin 43 trafficking.
• CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

ING1 has been shown to interact with:

{{div col|colwidth=20em}}

• CREB binding protein,
• DMAP1,{{cite journal | vauthors = Xin H, Yoon HG, Singh PB, Wong J, Qin J | title = Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9539–46 | date = Mar 2004 | pmid = 14665632 | doi = 10.1074/jbc.M311587200 | doi-access = free }}
• HDAC1,{{cite journal | vauthors = Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K | title = Human ING1 proteins differentially regulate histone acetylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29832–9 | date = Aug 2002 | pmid = 12015309 | doi = 10.1074/jbc.M200197200 | doi-access = free }}{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = Feb 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/mcb.22.3.835-848.2002}}
• P53,{{cite journal | vauthors = Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY | title = The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 | journal = Cancer Research | volume = 62 | issue = 17 | pages = 4890–3 | date = Sep 2002 | pmid = 12208736 }}{{cite journal | vauthors = Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV | title = The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control | journal = Nature | volume = 391 | issue = 6664 | pages = 295–8 | date = Jan 1998 | pmid = 9440695 | doi = 10.1038/34675 | bibcode = 1998Natur.391..295G | s2cid = 4429461 }}
• PCNA,{{cite journal | vauthors = Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K | title = UV-induced binding of ING1 to PCNA regulates the induction of apoptosis | journal = Journal of Cell Science | volume = 114 | issue = Pt 19 | pages = 3455–62 | date = Oct 2001 | doi = 10.1242/jcs.114.19.3455 | pmid = 11682605 }}
• SAP30,
• SIN3A,
• SMARCA4, and
• SMARCC1.

{{Div col end}}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Campos EI, Chin MY, Kuo WH, Li G | title = Biological functions of the ING family tumor suppressors | journal = Cellular and Molecular Life Sciences | volume = 61 | issue = 19–20 | pages = 2597–613 | date = Oct 2004 | pmid = 15526165 | doi = 10.1007/s00018-004-4199-4 | s2cid = 28889915 | pmc = 11924450 }}
• {{cite journal | vauthors = Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I | title = A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis | journal = Cancer Research | volume = 57 | issue = 7 | pages = 1255–8 | date = Apr 1997 | pmid = 9102209 }}
• {{cite journal | vauthors = Garkavtsev I, Riabowol K | title = Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 2014–9 | date = Apr 1997 | pmid = 9121449 | pmc = 232048 | doi = 10.1128/mcb.17.4.2014}}
• {{cite journal | vauthors = Zeremski M, Horrigan SK, Grigorian IA, Westbrook CA, Gudkov AV | title = Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34 | journal = Somatic Cell and Molecular Genetics | volume = 23 | issue = 3 | pages = 233–6 | date = May 1997 | pmid = 9330636 | doi = 10.1007/BF02721376 | s2cid = 24132112 }}
• {{cite journal | vauthors = Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV | title = The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control | journal = Nature | volume = 391 | issue = 6664 | pages = 295–8 | date = Jan 1998 | pmid = 9440695 | doi = 10.1038/34675 | bibcode = 1998Natur.391..295G | s2cid = 4429461 }}
• {{cite journal | vauthors = Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T, Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H | title = Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas | journal = Cancer Research | volume = 59 | issue = 21 | pages = 5521–8 | date = Nov 1999 | pmid = 10554029 }}
• {{cite journal | vauthors = Jäger D, Stockert E, Scanlan MJ, Güre AO, Jäger E, Knuth A, Old LJ, Chen YT | title = Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene | journal = Cancer Research | volume = 59 | issue = 24 | pages = 6197–204 | date = Dec 1999 | pmid = 10626813 }}
• {{cite journal | vauthors = Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D | title = Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions | journal = Genes, Chromosomes & Cancer | volume = 27 | issue = 3 | pages = 319–22 | date = Mar 2000 | pmid = 10679922 | doi = 10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P | s2cid = 19406780 }}
• {{cite journal | vauthors = Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, Sugimachi K | title = Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers | journal = Cancer Letters | volume = 152 | issue = 1 | pages = 15–22 | date = Apr 2000 | pmid = 10754201 | doi = 10.1016/S0304-3835(99)00434-6 }}
• {{cite journal | vauthors = Baranova AV, Ivanov DV, Makeeva NV, Corcoran M, Nikitin EA, Borodina TA, Poltaraus AB, Glinshchikova OA, Sudarikov AB, Oscier D, Iankovskiĭ NK | title = [Genomic organization of the suppressor gene for tumor growth ING1] | journal = Molekuliarnaia Biologiia | volume = 34 | issue = 2 | pages = 263–9 | year = 2000 | pmid = 10779953 }}
• {{cite journal | vauthors = Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A | title = p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1 | journal = Journal of Human Genetics | volume = 45 | issue = 3 | pages = 177–81 | year = 2000 | pmid = 10807544 | doi = 10.1007/s100380050206 | doi-access = free }}
• {{cite journal | vauthors = Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K | title = Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas | journal = Cancer Research | volume = 60 | issue = 12 | pages = 3143–6 | date = Jun 2000 | pmid = 10866301 }}
• {{cite journal | vauthors = Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J | title = Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 12 | pages = 8734–9 | date = Mar 2001 | pmid = 11118440 | doi = 10.1074/jbc.M007664200 | doi-access = free }}
• {{cite journal | vauthors = Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC | title = DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 17 | pages = 9671–6 | date = Aug 2001 | pmid = 11481424 | pmc = 55510 | doi = 10.1073/pnas.161151798 | bibcode = 2001PNAS...98.9671N | doi-access = free }}
• {{cite journal | vauthors = Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K | title = UV-induced binding of ING1 to PCNA regulates the induction of apoptosis | journal = Journal of Cell Science | volume = 114 | issue = Pt 19 | pages = 3455–62 | date = Oct 2001 | doi = 10.1242/jcs.114.19.3455 | pmid = 11682605 }}
• {{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = Feb 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002 }}
• {{cite journal | vauthors = Nouman GS, Angus B, Lunec J, Crosier S, Lodge A, Anderson JJ | title = Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues | journal = Hybridoma and Hybridomics | volume = 21 | issue = 1 | pages = 1–10 | date = Feb 2002 | pmid = 11991811 | doi = 10.1089/15368590252917584 }}
• {{cite journal | vauthors = Bromidge T, Lynas C | title = Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies | journal = Leukemia Research | volume = 26 | issue = 7 | pages = 631–5 | date = Jul 2002 | pmid = 12008079 | doi = 10.1016/S0145-2126(01)00185-0 }}

{{refend}}

• {{MeshName|ING1+protein,+human}}

{{NLM content}}

{{Transcription factors|g2}}

Category:Transcription factors