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IWS1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.{{cite web | title = Entrez Gene: IWS1 IWS1 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55677| accessdate = }}

IWS1 is a transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.{{cite journal | vauthors = Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF | title = RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach | journal = Molecular and Cellular Biology | volume = 22 | issue = 20 | pages = 6979–92 | date = Oct 2002 | pmid = 12242279 | pmc = 139818 | doi = 10.1128/MCB.22.20.6979-6992.2002 }}

The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.{{cite journal | vauthors = Liu Z, Zhou Z, Chen G, Bao S | title = A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation | journal = Biochemical and Biophysical Research Communications | volume = 353 | issue = 1 | pages = 47–53 | date = Feb 2007 | pmid = 17184735 | doi = 10.1016/j.bbrc.2006.11.133 }} It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.{{cite journal | vauthors = Yoh SM, Lucas JS, Jones KA | title = The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation | journal = Genes & Development | volume = 22 | issue = 24 | pages = 3422–34 | date = Dec 2008 | pmid = 19141475 | pmc = 2607075 | doi = 10.1101/gad.1720008 }}

References

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Further reading

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  • {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
  • {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
  • {{cite journal | vauthors = Ling Y, Smith AJ, Morgan GT | title = A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS | journal = Nucleic Acids Research | volume = 34 | issue = 8 | pages = 2219–29 | year = 2006 | pmid = 16648364 | pmc = 1450333 | doi = 10.1093/nar/gkl239 }}
  • {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
  • {{cite journal | vauthors = Liu Z, Zhou Z, Chen G, Bao S | title = A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation | journal = Biochemical and Biophysical Research Communications | volume = 353 | issue = 1 | pages = 47–53 | date = Feb 2007 | pmid = 17184735 | doi = 10.1016/j.bbrc.2006.11.133 }}
  • {{cite journal | vauthors = Yoh SM, Cho H, Pickle L, Evans RM, Jones KA | title = The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export | journal = Genes & Development | volume = 21 | issue = 2 | pages = 160–74 | date = Jan 2007 | pmid = 17234882 | pmc = 1770899 | doi = 10.1101/gad.1503107 }}

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