List of hormonal cytostatic antineoplastic agents
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{{More refs|date=March 2025}}File:Estramustine_phosphate.svg, the only dual hormonal and cytostatic antineoplastic agent to have been marketed. A normustine and phosphate ester of estradiol. Used in the treatment of prostate cancer.]]
This is a list of dual hormonal and cytostatic antineoplastic agents.
Marketed
=Estrogen-based=
- Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC-89199, Ro 21-8837/001; estradiol 3-[bis(2-chloroethyl)carbamate] dihydrogen phosphate) – arrests anaphase stage of cell division{{Citation |last=Zhao |first=Qingjie |title=Anticancer Hybrids |date=2017 |work=Design of Hybrid Molecules for Drug Development |pages=193–218 |url=https://linkinghub.elsevier.com/retrieve/pii/B9780081010112000076 |access-date=2025-03-07 |publisher=Elsevier |language=en |doi=10.1016/b978-0-08-101011-2.00007-6 |isbn=978-0-08-101011-2 |last2=Huang |first2=Guozheng|url-access=subscription }}
=Corticosteroid-based=
- Prednimustine (Mostarina, Sterecyst; chlorambucil prednisolone ester; prednisolone 21-(4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate))
Never marketed
=Estrogen-based=
- Alestramustine (estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(L-alaninate))
- Atrimustine (bestrabucil, busramustine; KM-2210; estradiol 3-benzoate 17β-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate)
- Cytestrol acetate (1α-hydroxyethinylestradiol 3-(bis(2-chloroethyl)carbamate) 11α,17β-diacetate)
- Estradiol mustard (NSC-112259; chlorphenacyl estradiol diester; estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate)
- Estramustine (Leo 275, Ro 21–8837; estradiol 3-(bis(2-chloroethyl)carbamate) ester)
- Estromustine (Leo 271 f; estrone-cytostatic complex; estrone 17β-3-N-bis(2-chloroethyl)carbamate)
- ICI-85966 (Stilbostat; diethylstilbestrol bis(di(2-chloroethyl)carbamate)
- Phenestrol (fenestrol; NSC-183736; hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate)
=Androgen-based=
- LS-1727 (nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate)
- Sturamustine (dehydroepiandrosterone 17β-N-(2-chloroethyl)-N-nitrosourea)
- Testifenon (testiphenon, testiphenone; chlorphenacyl dihydrotestosterone ester; dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate)
=Corticosteroid-based=
- Cortifen (cortiphen, kortifen, fencoron; chlorphenacyl 11-deoxycortisol ester; 11-deoxycortisol 21-(4-(bis(2-chloroethyl)amino)phenyl)acetate)