RBBP7

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.{{cite web | title = Entrez Gene: RBBP7 retinoblastoma binding protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5931}}

RBBP7 has been shown to interact with:

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• BRCA1,{{cite journal | vauthors = Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY | title = Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1 | journal = Biochem. Biophys. Res. Commun. | volume = 284 | issue = 2 | pages = 507–14 | date = June 2001 | pmid = 11394910 | doi = 10.1006/bbrc.2001.5003 }}{{cite journal | vauthors = Yarden RI, Brody LC | title = Identification of proteins that interact with BRCA1 by Far-Western library screening | journal = J. Cell. Biochem. | volume = 83 | issue = 4 | pages = 521–31 | pmid = 11746496 | doi = 10.1002/jcb.1257| year = 2001 | s2cid = 29703139 | url = https://zenodo.org/record/1229223 }}
• GATAD2B,{{cite journal | vauthors = Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y | title = Identification and functional characterization of the p66/p68 components of the MeCP1 complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 2 | pages = 536–46 | date = January 2002 | pmid = 11756549 | pmc = 139742 | doi = 10.1128/mcb.22.2.536-546.2002}}
• HDAC1,{{cite journal | vauthors = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | journal = J. Biol. Chem. | volume = 278 | issue = 43 | pages = 42560–8 | date = October 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200 | doi-access = free }}{{cite journal | vauthors = Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A | title = MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex | journal = Nat. Genet. | volume = 23 | issue = 1 | pages = 58–61 | date = September 1999 | pmid = 10471499 | doi = 10.1038/12659 | hdl = 1842/684 | s2cid = 6147725 | hdl-access = free }}{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes Dev. | volume = 13 | issue = 15 | pages = 1924–35 | date = August 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924}}{{cite journal | vauthors = Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex | journal = Cell | volume = 89 | issue = 3 | pages = 357–64 | date = May 1997 | pmid = 9150135 | doi = 10.1016/s0092-8674(00)80216-0| doi-access = free }}
• MTA2,
• Retinoblastoma protein,{{cite journal | vauthors = Yarden RI, Brody LC | title = BRCA1 interacts with components of the histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4983–8 | date = April 1999 | pmid = 10220405 | pmc = 21803 | doi = 10.1073/pnas.96.9.4983| bibcode = 1999PNAS...96.4983Y | doi-access = free }}
• SAP30, and
• SIN3A.{{cite journal | vauthors = Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D | title = SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex | journal = Mol. Cell | volume = 1 | issue = 7 | pages = 1021–31 | date = June 1998 | pmid = 9651585 | doi = 10.1016/s1097-2765(00)80102-1| doi-access = free }}{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 835–48 | date = February 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/mcb.22.3.835-848.2002}}

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• {{cite journal | vauthors = Huang S, Lee WH, Lee EY | title = A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product | journal = Nature | volume = 350 | issue = 6314 | pages = 160–162 | year = 1991 | pmid = 2005966 | doi = 10.1038/350160a0 | bibcode = 1991Natur.350..160H | s2cid = 4345233 }}
• {{cite journal | vauthors = Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex | journal = Cell | volume = 89 | issue = 3 | pages = 357–364 | year = 1997 | pmid = 9150135 | doi = 10.1016/S0092-8674(00)80216-0 | doi-access = free }}
• {{cite journal | vauthors = Verreault A, Kaufman PD, Kobayashi R, Stillman B | title = Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase | journal = Curr. Biol. | volume = 8 | issue = 2 | pages = 96–108 | year = 1998 | pmid = 9427644 | doi = 10.1016/S0960-9822(98)70040-5 | s2cid = 201273 | doi-access = free | bibcode = 1998CBio....8...96V }}
• {{cite journal | vauthors = Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D | title = SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex | journal = Mol. Cell | volume = 1 | issue = 7 | pages = 1021–1031 | year = 1998 | pmid = 9651585 | doi = 10.1016/S1097-2765(00)80102-1 | doi-access = free }}
• {{cite journal | vauthors = Guan LS, Rauchman M, Wang ZY | title = Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27047–27050 | year = 1998 | pmid = 9765217 | doi = 10.1074/jbc.273.42.27047 | doi-access = free }}
• {{cite journal | vauthors = Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D | title = The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities | journal = Cell | volume = 95 | issue = 2 | pages = 279–289 | year = 1998 | pmid = 9790534 | doi = 10.1016/S0092-8674(00)81758-4 | s2cid = 18786866 | doi-access = free }}
• {{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–921 | year = 1998 | pmid = 9804427 | doi = 10.1038/27699 | bibcode = 1998Natur.395..917T | s2cid = 4355885 }}
• {{cite journal | vauthors = Yarden RI, Brody LC | title = BRCA1 interacts with components of the histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4983–4988 | year = 1999 | pmid = 10220405 | pmc = 21803 | doi = 10.1073/pnas.96.9.4983 | bibcode = 1999PNAS...96.4983Y | doi-access = free }}
• {{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes Dev. | volume = 13 | issue = 15 | pages = 1924–1935 | year = 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}
• {{cite journal | vauthors = Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP | title = Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation | journal = Nat. Genet. | volume = 23 | issue = 1 | pages = 62–66 | year = 1999 | pmid = 10471500 | doi = 10.1038/12664 | s2cid = 52868103 }}
• {{cite journal | vauthors = Zhang Q, Vo N, Goodman RH | title = Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 4970–4978 | year = 2000 | pmid = 10866654 | pmc = 85947 | doi = 10.1128/MCB.20.14.4970-4978.2000 }}
• {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = J. Biol. Chem. | volume = 276 | issue = 9 | pages = 6817–6824 | year = 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 | doi-access = free }}
• {{cite journal | vauthors = Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J | title = Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 8734–8739 | year = 2001 | pmid = 11118440 | doi = 10.1074/jbc.M007664200 | doi-access = free }}
• {{cite journal | vauthors = Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY | title = Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1 | journal = Biochem. Biophys. Res. Commun. | volume = 284 | issue = 2 | pages = 507–514 | year = 2001 | pmid = 11394910 | doi = 10.1006/bbrc.2001.5003 }}
• {{cite journal | vauthors = Yarden RI, Brody LC | title = Identification of proteins that interact with BRCA1 by Far-Western library screening | journal = J. Cell. Biochem. | volume = 83 | issue = 4 | pages = 521–531 | year = 2002 | pmid = 11746496 | doi = 10.1002/jcb.1257 | s2cid = 29703139 | url = https://zenodo.org/record/1229223 }}
• {{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 835–848 | year = 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002 }}
• {{cite journal | vauthors = Vaute O, Nicolas E, Vandel L, Trouche D | title = Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases | journal = Nucleic Acids Res. | volume = 30 | issue = 2 | pages = 475–481 | year = 2002 | pmid = 11788710 | pmc = 99834 | doi = 10.1093/nar/30.2.475 }}
• {{cite journal | vauthors = Saito M, Ishikawa F | title = The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35434–35439 | year = 2002 | pmid = 12124384 | doi = 10.1074/jbc.M203455200 | doi-access = free }}
• {{cite journal | vauthors = Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein | journal = Genes Dev. | volume = 16 | issue = 22 | pages = 2893–2905 | year = 2002 | pmid = 12435631 | pmc = 187479 | doi = 10.1101/gad.1035902 }}

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Category:Genes mutated in mice