daf-3

{{single source|date=July 2020}}

{{Infobox nonhuman protein

| Name = Dwarfin sma

| image =

| width =

| caption =

| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-3

| AltSymbols =

| EntrezGene = 180431

| HomoloGene =

| PDB =

| RefSeqmRNA = NM_075760.6

| RefSeqProtein = NP_508161.3

| UniProt = Q95QI7

| Chromosome = X

| EntrezChromosome = NC_003284.9

| GenLoc_start = 817927

| GenLoc_end = 825475

}}

The DAF-3 or Dwarfin sma is a nematode Caenorhabditis elegans gene encoding a Co-SMAD protein of TGF-beta signaling pathway. Without daf-7 signal, DAF-3 combined with transcription factor daf-5 to form a heterodimer and started dauer development. When daf-7 binds to the receptors daf-1/daf-4, the phosphorylated daf-8/daf-14 heterodimer enter to the nucleus to inhibit this transcription.{{cite journal | vauthors = Gumienny TL, Savage-Dunn C | title = TGF-β signaling in C. elegans | journal = WormBook | pages = 1–34 | date = July 2013 | pmid = 23908056 | doi = 10.1895/wormbook.1.22.2 | pmc = 5081272 }}