daf-8

{{Infobox nonhuman protein

| Name = Dwarfin sma

| image =

| width =

| caption =

| Organism = Caenorhabditis elegans

| TaxID = 6239

| Symbol = daf-8

| AltSymbols =

| EntrezGene = 187612

| HomoloGene =

| PDB =

| RefSeqmRNA = NM_059920.3

| RefSeqProtein = NP_492321.1

| UniProt =Q21733

| Chromosome = I

| EntrezChromosome = NC_003279.8

| GenLoc_start = 8584081

| GenLoc_end = 8587505

}}

The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.{{cite journal | vauthors = Li FF, Gasser RB, Liu F, Shan JN, Di WD, He L, Zhou CX, Wang CQ, Fang R, Hu M | display-authors = 6 | title = Identification and characterization of an R-Smad homologue (Hco-DAF-8) from Haemonchus contortus | journal = Parasites & Vectors | volume = 13 | issue = 1 | pages = 164 | date = April 2020 | pmid = 32245505 | doi = 10.1186/s13071-020-04034-0 | pmc = 7119156 | doi-access = free }} When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.{{cite journal | vauthors = Gumienny TL, Savage-Dunn C | title = TGF-β signaling in C. elegans | journal = WormBook | pages = 1–34 | date = July 2013 | pmid = 23908056 | doi = 10.1895/wormbook.1.22.2 | pmc = 5081272 }}