2021 Baltimore Orioles season

{{2021 AL East standings|highlight=Baltimore Orioles}}

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{{2021 AL Wild Card standings|highlight=Baltimore Orioles}}

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Updated through game of October 3.

{{dagger}} Minimum 3.1 plate appearances per team games played

{{spaces|3}}AVG qualified batters: Mullins, Mountcastle, Mancini, Hays

{{double dagger}} Minimum 1 inning pitched per team games played

{{spaces|3}}ERA & WHIP qualified pitchers: No qualifiers

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{{2021 AL Record vs. opponents|team=BAL}}

{{Game log start|style={{Baseball primary style|Baltimore Orioles}};|title=2021 Game Log: 52–110 (Home: 27–54; Away: 25–56)}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=April: 12–14 (Home: 4–10; Away: 8–4)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/
Box}}

|- style="background:#bbb;"

| — || April 1 || @ Red Sox || colspan=7 | Postponed (rain). Makeup date April 2.{{cite web |title=Sox-O's postponed to Friday due to rain |url=https://www.mlb.com/orioles/news/red-sox-orioles-2021-opening-day-postponed |website=orioles.com |publisher= |access-date=April 1, 2021}}

|- style="background:#bfb;"

| 1 || April 2 || @ Red Sox || 3–0 || Means (1–0) || Eovaldi (0–1) || Valdez (1) || 4,452 || 1–0 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/04/02/634627#game_state=final,lock_state=final,game_tab=box,game=634627 W1]

|- style="background:#bfb;"

| 2 || April 3 || @ Red Sox || 4–2 || Plutko (1–0) || Houck (0–1) || Valdez (2) || 4,571 || 2–0 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/04/03/634577#game_state=final,game_tab=box,game=634577 W2]

|- style="background:#bfb;"

| 3 || April 4 || @ Red Sox || 11–3 || Zimmermann (1–0) || Richards (0–1) || — || 4,458 || 3–0 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/04/04/634610#game_state=final,game_tab=box,game=634610 W3]

|- style="background:#fbb;"

| 4 || April 5 || @ Yankees || 0–7 || Montgomery (1–0) || López (0–1) || — || 9,008 || 3–1 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/04/05/634587#game_state=final,game_tab=box,game=634587 L1]

|- style="background:#fbb;"

| 5 || April 6 || @ Yankees || 2–7 || Cole (1–0) || Kremer (0–1) || — || 9,404 || 3–2 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/04/06/634599#game_state=final,lock_state=final,game_tab=box,game=634599 L2]

|- style="background:#bfb;"

| 6 || April 7 || @ Yankees || 4–3 {{small|(11)}} || Valdez (1–0) || Green (0–1) || Fry (1) || 10,254 || 4–2 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/04/07/634539#game_state=final,game_tab=box,game=634539 W1]

|- style="background:#fbb;"

| 7 || April 8 || Red Sox || 3–7 || Rodríguez (1–0) || Harvey (0–1) || — || 10,150 || 4–3 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/04/08/634544#game_state=final,game_tab=box,game=634544 L1]

|- style="background:#fbb;"

| 8 || April 10 || Red Sox || 4–6 {{small|(10)}} || Barnes (1–0) || Tate (0–1) || Andriese (1) || 9,307 || 4–4 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/04/10/634491#game_state=final,game_tab=box,game=634491 L2]

|- style="background:#fbb;"

| 9 || April 11 || Red Sox || 9–14 || Pivetta (2–0) || López (0–2) || — || 8,171 || 4–5 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/04/11/632200#game_state=final,lock_state=final,game_tab=wrap,game=632200 L3]

|- style="background:#bbb;"

| — || April 12 || Mariners || colspan=7 | Postponed (rain). Makeup date April 13 as part of doubleheader.{{Cite web|title=Tonight's Orioles-Mariners game postponed due to rain|url=https://www.mlb.com/press-release/press-release-tonight-s-orioles-mariners-game-postponed-due-to-rain|access-date=April 13, 2021|website=MLB.com|language=en}}

|- style="background:#fbb;"

| 10 || April 13 || Mariners || 3–4 {{small|(8)}} || Montero (1–0) || Scott (0–1) || Graveman (1) || 4,147{{Efn|name=a|Single-admission doubleheader}} || 4–6 || [https://www.mlb.com/gameday/mariners-vs-orioles/2021/04/13/632213#game_state=final,game_tab=box,game=632213 L4]

|- style="background:#bfb;"

| 11 || April 13 || Mariners || 7–6 {{small|(7)}} || Valdez (2–0) || Sadler (0–1) || — || 4,147{{Efn|name=a}} || 5–6 || [https://www.mlb.com/gameday/mariners-vs-orioles/2021/04/13/632224#game_state=final,game_tab=box,game=632224 W1]

|- style="background:#bbb;"

| — || April 14 || Mariners || colspan=7 | Postponed (rain). Makeup date April 15 as part of doubleheader.{{Cite web|title=Mariners-O's postponed; DH on Thursday|url=https://www.mlb.com/orioles/news/mariners-orioles-april-14-game-postponed|accessdate=April 14, 2021|website=MLB.com|language=en}}

|- style="background:#fbb;"

| 12 || April 15 || Mariners || 2–4 {{small|(7)}} || Gonzales (1–1) || Scott (0–2) || Graveman (2) || 5,060{{Efn|name=b|Single-admission doubleheader}} || 5–7 || [https://www.mlb.com/gameday/mariners-vs-orioles/2021/04/15/634571#game_state=final,game_tab=box,game=634571 L1]

|- style="background:#fbb;"

| 13 || April 15 || Mariners || 1–2 {{small|(7)}} || Dunn (1–0) || Zimmermann (1–1) || Middleton (2) || 5,060{{Efn|name=b}} || 5–8 || [https://www.mlb.com/gameday/mariners-vs-orioles/2021/04/15/634472#game_state=final,game_tab=box,game=634472 L2]

|- style="background:#bfb;"

| 14 || April 16 || @ Rangers || 5–2 || López (1–2) || Foltynewicz (0–3) || Valdez (3) || 22,173 || 6–8 || [https://www.mlb.com/gameday/orioles-vs-rangers/2021/04/16/634463#game_state=final,game_tab=box,game=634463 W1]

|- style="background:#bfb;"

| 15 || April 17 || @ Rangers || 6–1 || Lakins (1–0) || Rodríguez (0–1) || — || 29,338 || 7–8 || [https://www.mlb.com/gameday/orioles-vs-rangers/2021/04/17/634543#game_state=final,game_tab=box,game=634543 W2]

|- style="background:#fbb;"

| 16 || April 18 || @ Rangers || 0–1 {{small|(10)}} || King (1–0) || Lakins (1–1) || — || 24,267 || 7–9 || [https://www.mlb.com/gameday/orioles-vs-rangers/2021/04/18/634511#game_state=final,game_tab=box,game=634511 L1]

|- style="background:#bfb;"

| 17 || April 20 || @ Marlins || 7–5 || Harvey (1–1) || Neidert (0–1) || Valdez (4) || 4,540 || 8–9 || [https://www.mlb.com/gameday/orioles-vs-marlins/2021/04/20/634427#game_state=final,lock_state=final,game_tab=box,game=634427 W1]

|- style="background:#fbb;"

| 18 || April 21 || @ Marlins || 0–3 || Rogers (1–2) || Zimmermann (1–2) || García (4) || 4,028 || 8–10 || [https://www.mlb.com/gameday/orioles-vs-marlins/2021/04/21/634497#game_state=final,game_tab=box,game=634497 L1]

|- style="background:#fbb;"

| 19 || April 23 || Athletics || 1–3 || Irvin (2–2) || López (1–3) || Diekman (2) || 7,574 || 8–11 || [https://www.mlb.com/gameday/athletics-vs-orioles/2021/04/23/634389#game_state=final,game_tab=box,game=634389 L2]

|- style="background:#fbb;"

| 20 || April 24 || Athletics || 2–7 || Bassitt (2–2) || LeBlanc (0–1) || — || 7,616 || 8–12 || [https://www.mlb.com/gameday/athletics-vs-orioles/2021/04/24/634367#game_state=final,lock_state=final,game_tab=box,game=634367 L3]

|- style="background:#bfb;"

| 21 || April 25 || Athletics || 8–1 || Means (2–0) || Luzardo (1–2) || — || 8,107 || 9–12 || [https://www.mlb.com/gameday/athletics-vs-orioles/2021/04/25/634454#game_state=final,game_tab=box,game=634454 W1]

|- style="background:#bfb;"

| 22 || April 26 || Yankees || 4–2 || Harvey (2–1) || García (0–1) || Valdez (5) || 6,367 || 10–12 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/04/26/634433?gid=2021_04_26_nyamlb_balmlb_1&partnerId=LR_gameday#game_state=final,game_tab=box,game=634433 W2]

|- style="background:#fbb;"

| 23 || April 27 || Yankees || 1–5 || Kluber (1–2) || Zimmermann (1–3) || — || 6,662 || 10–13 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/04/27/634387#game_state=final,game_tab=box,game=634387 L1]

|- style="background:#fbb;"

| 24 || April 28 || Yankees || 0–7 || Germán (2–2) || Kremer (0–2) || — || 7,338 || 10–14 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/04/28/634362#game_state=final,game_tab=box,game=634362 L2]

|- style="background:#bfb;"

| 25 || April 29 || Yankees || 4–3 {{small|(10)}} || Scott (1–2) || Loaisiga (2–1) || — || 7,738 || 11–14 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/04/29/634300#game_state=final,lock_state=final,game_tab=box,game=634300 W1]

|- style="background:#bfb;"

| 26 || April 30 || @ Athletics || 3–2 || Means (3–0) || Fiers (0–1) || Valdez (6) || 5,777 || 12–14 || [https://www.mlb.com/gameday/orioles-vs-athletics/2021/04/30/634381#game_state=final,game_tab=box,game=634381 W2]

|-

{{Game log section end}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=May: 5–23 (Home: 2–9; Away: 3–14)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/Box}}

|- style="background:#bfb;"

| 27 || May 1 || @ Athletics || 8–4 || Harvey (3–1) || Luzardo (1–3) || — || 6,469 || 13–14 || [https://www.mlb.com/gameday/orioles-vs-athletics/2021/05/01/634319#game_state=final,game_tab=box,game=634319 W3]

|- style="background:#fbb;"

| 28 || May 2 || @ Athletics || 5–7 || Petit (4–0) || Lakins (1–2) || Trivino (5) || 5,862 || 13–15 || [https://www.mlb.com/gameday/orioles-vs-athletics/2021/05/02/634306#game_state=final,game_tab=box,game=634306 L1]

|- style="background:#bfb;"

| 29 || May 3 || @ Mariners || 5–3 || Sulser (1-0) || Misiewicz (2–1) || Valdez (7) || 5,776 || 14–15 || [https://www.mlb.com/gameday/orioles-vs-mariners/2021/05/03/634242#game_state=final,game_tab=box,game=634242 W1]

|- style="background:#fbb;"

| 30 || May 4 || @ Mariners || 2–5 || Montero (3–1) || Lakins (1–3) || — || 6,504 || 14–16 || [https://www.mlb.com/gameday/orioles-vs-mariners/2021/05/04/634265#game_state=final,game_tab=box,game=634265 L1]

|- style="background:#bfb;"

| 31 || May 5 || @ Mariners || 6–0 || Means (4–0) || Kikuchi (1–2) || — || 6,742 || 15–16 || [https://www.mlb.com/gameday/orioles-vs-mariners/2021/05/05/634220#game_state=final,game_tab=box,game=634220 W1]

|- style="background:#fbb;"

| 32 || May 7 || Red Sox || 2–6 || Rodríguez (5–0) || Harvey (3–2) || — || 7,724 || 15–17 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/05/07/634209#game_state=final,game_tab=box,game=634209 L1]

|- style="background:#fbb;"

| 33 || May 8 || Red Sox || 6–11 || Richards (2–2) || Lowther (0–1) || — || 10,598 || 15–18 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/05/08/634196#game_state=final,game_tab=box,game=634196 L2]

|- style="background:#fbb;"

| 34 || May 9 || Red Sox || 3–4 || Pivetta (5–0) || Kremer (0–3) || Barnes (8) || 10,274 || 15–19 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/05/09/634177#game_state=final,game_tab=box,game=634177 L3]

|- style="background:#bfb;"

| 35 || May 10 || Red Sox || 4–1 || Scott (2–2) || Andriese (1–2) || Valdez (8) || 6,826 || 16–19 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/05/10/634176#game_state=final,game_tab=box,game=634176 W1]

|- style="background:#fbb;"

| 36 || May 11 || @ Mets || 2–3 || Familia (1–0) || Valdez (2–1) || — || 7,930 || 16–20 || [https://www.mlb.com/gameday/orioles-vs-mets/2021/05/11/634170#game_state=final,game_tab=box,game=634170 L1]

|- style="background:#fbb;"

| 37 || May 12 || @ Mets || 1–7 || Walker (3–1) || Harvey (3–3) || — || 8,035 || 16–21 || [https://www.mlb.com/gameday/orioles-vs-mets/2021/05/12/634128#game_state=final,game_tab=box,game=634128 L2]

|- style="background:#fbb;"

| 38 || May 14 || Yankees || 4–5 || Kluber (3–2) || Lakins (1–4) || Loáisiga (2) || 10,809 || 16–22 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/05/14/634146#game_state=final,game_tab=box,game=634146 L3]

|- style="background:#fbb;"

| 39 || May 15 || Yankees || 2–8 || Germán (3–2) || López (1–4) || — || 10,767 || 16–23 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/05/15/634104#game_state=final,game_tab=box,game=634104 L4]

|- style="background:#bfb;"

| 40 || May 16 || Yankees || 10–6 || Zimmermann (2–3) || King (0–1) || — || 11,070 || 17–23 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/05/16/634086#game_state=final,game_tab=box,game=634086 W1]

|- style="background:#fbb;"

| 41 || May 18 || Rays || 6–13 || Kittredge (4–0) || Harvey (3–4) || — || 5,429 || 17–24 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/05/18/634075#game_state=final,game_tab=box,game=634075 L1]

|- style="background:#fbb;"

| 42 || May 19 || Rays || 7–9 || Thompson (3–2) || Fry (0–1) || Fairbanks (1) || 6,581 || 17–25 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/05/19/634055#game_state=final,game_tab=box,game=634055 L2]

|- style="background:#fbb;"

| 43 || May 20 || Rays || 1–10 || Hill (3–1) || Kremer (0–4) || — || 6,916 || 17–26 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/05/20/634120#game_state=final,game_tab=box,game=634120 L3]

|- style="background:#fbb;"

| 44 || May 21 || @ Nationals || 2–4 || Strasburg (1–1) || López (1–5) || — || 14,369 || 17–27 || [https://www.mlb.com/gameday/orioles-vs-nationals/2021/05/21/634012#game_state=final,game_tab=box,game=634012 L4]

|- style="background:#fbb;"

| 45 || May 22 || @ Nationals || 9–12 || Hudson (3–0) || Plutko (1–1) || Hand (6) || 15,440 || 17–28 || [https://www.mlb.com/gameday/orioles-vs-nationals/2021/05/22/634062#game_state=final,game_tab=box,game=634062 L5]

|- style="background:#fbb;"

| 46 || May 23 || @ Nationals || 5–6 || Corbin (3–3) || Harvey (3–5) || Hand (7) || 14,618 || 17–29 || [https://www.mlb.com/gameday/orioles-vs-nationals/2021/05/23/633977#game_state=final,game_tab=box,game=633977 L6]

|- style="background:#fbb;"

| 47 || May 24 || @ Twins || 3–8 || Alcalá (1–1) || Scott (2–3) || — || 8,530 || 17–30 || [https://www.mlb.com/gameday/orioles-vs-twins/2021/05/24/633982#game_state=final,lock_state=final,game_tab=box,game=633982 L7]

|- style="background:#fbb;"

| 48 || May 25 || @ Twins || 4–7 || Berríos (5–2) || Kremer (0–5) || Rogers (3) || 9,969 || 17–31 || [https://www.mlb.com/gameday/orioles-vs-twins/2021/05/25/634048#game_state=final,game_tab=box,game=634048 L8]

|- style="background:#fbb;"

| 49 || May 26 || @ Twins || 2–3 || Pineda (3–2) || López (1–6) || Robles (3) || 10,574 || 17–32 || [https://www.mlb.com/gameday/orioles-vs-twins/2021/05/26/633928#game_state=final,game_tab=box,game=633928 L9]

|- style="background:#fbb;"

| 50 || May 27 || @ White Sox || 1–5 || Cease (3–1) || Tate (0–2) || — || 9,671 || 17–33 || [https://www.mlb.com/gameday/orioles-vs-white-sox/2021/05/27/633924#game_state=final,game_tab=box,game=633924 L10]

|- style="background:#bbb;"

| — || May 28 || @ White Sox || colspan=7 | Postponed (rain). Makeup date May 29 as part of doubleheader.

|- style="background:#fbb;"

| 51 || May 29 || @ White Sox || 4–7 {{small|(7)}} || Keuchel (4–1) || Harvey (3–6) || Hendriks (11) || 20,029{{Efn|name=c|Single-admission doubleheader}} || 17–34 || [https://www.mlb.com/gameday/padres-vs-astros/2021/05/29/633874#game_state=live,game_tab=box,game=633874 L11]

|- style="background:#fbb;"

| 52 || May 29 || @ White Sox || 1–3 {{small|(7)}} || Lynn (6–1) || Means (4–1) || Hendriks (12) || 20,029{{Efn|name=c}} || 17–35 || [https://www.mlb.com/gameday/orioles-vs-white-sox/2021/05/29/633887#game_state=final,game_tab=box,game=633887 L12]

|- style="background:#fbb;"

| 53 || May 30 || @ White Sox || 1–3 || Giolito (5–4) || Tate (0–3) || Hendriks (13) || 21,067 || 17–36 || [https://www.mlb.com/gameday/orioles-vs-white-sox/2021/05/30/633872#game_state=final,game_tab=box,game=633872 L13]

|- style="background:#fbb;"

| 54 || May 31 || Twins || 2–3 {{small|(10)}} || Rogers (3–3) || Plutko (1–2) || Robles (4) || 11,010 || 17–37 || [https://www.mlb.com/gameday/twins-vs-orioles/2021/05/31/633919#game_state=final,lock_state=final,game_tab=box,game=633919 L14]

|-

{{Game log section end}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=June: 10–17 (Home: 6–7; Away: 4–10)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/Box}}

|- style="background:#bfb;"

| 55 || June 1 || Twins || 7–4 || Zimmermann (3–3) || Pineda (3–3) || Sulser (1) || 5,337 || 18–37 || [https://www.mlb.com/gameday/twins-vs-orioles/2021/06/01/633856#game_state=final,game_tab=box,game=633856 W1]

|- style="background:#bfb;"

| 56 || June 2 || Twins || 6–3 || T. Wells (1–0) || Dobnak (1–5) || — || 5,945 || 19–37 || [https://www.mlb.com/gameday/twins-vs-orioles/2021/06/02/633853#game_state=final,game_tab=box,game=633853 W2]

|- style="background:#bfb;"

| 57 || June 4 || Indians || 3–1 || Sulser (2–0) || Shaw (1–1) || Fry (2) || 12,009 || 20–37 || [https://www.mlb.com/gameday/indians-vs-orioles/2021/06/04/633818#game_state=final,game_tab=box,game=633818 W3]

|- style="background:#fbb;"

| 58 || June 5 || Indians || 4–10 || Civale (8–2) || Means (4–2) || — || 9,969 || 20–38 || [https://www.mlb.com/gameday/indians-vs-orioles/2021/06/05/633807#game_state=final,game_tab=box,game=633807 L1]

|- style="background:#bfb;"

| 59 || June 6 || Indians || 18–5 || López (2–6) || Quantrill (0–2) || — || 9,423 || 21–38 || [https://www.mlb.com/gameday/indians-vs-orioles/2021/06/06/633814#game_state=final,game_tab=box,game=633814 W1]

|- style="background:#bfb;"

| 60 || June 8 || Mets || 10–3 || Zimmermann (4–3) || Peterson (1–5) || — || 9,431 || 22–38 || [https://www.mlb.com/gameday/mets-vs-orioles/2021/06/08/633773#game_state=final,lock_state=final,game_tab=box,game=633773 W2]

|- style="background:#fbb;"

| 61 || June 9 || Mets || 1–14 || Walker (5–2) || Harvey (3–7) || — || 9,584 || 22–39 || [https://www.mlb.com/gameday/mets-vs-orioles/2021/06/09/633811#game_state=final,game_tab=box,game=633811 L1]

|- style="background:#fbb;"

| 62 || June 11 || @ Rays || 2–4 || Yarbrough (4–3) || Akin (0–1) || Fairbanks (2) || 6,211 || 22–40 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/06/11/633781#game_state=final,game_tab=box,game=633781 L2]

|- style="background:#fbb;"

| 63 || June 12 || @ Rays || 4–5 || McHugh (1–1) || López (2–7) || Castillo (11) || 9,225 || 22–41 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/06/12/633699#game_state=final,game_tab=box,game=633699 L3]

|- style="background:#fbb;"

| 64 || June 13 || @ Rays || 1–7 || Fleming (6–4) || Zimmermann (4–4) || — || 9,101 || 22–42 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/06/13/633737#game_state=final,game_tab=box,game=633737 L4]

|- style="background:#fbb;"

| 65 || June 14 || @ Indians || 3–4 || Sandlin (1–0) || Kremer (0–6) || Clase (10) || 11,181 || 22–43 || [https://www.mlb.com/gameday/orioles-vs-indians/2021/06/14/633705#game_state=final,game_tab=box,game=633705 L5]

|- style="background:#fbb;"

| 66 || June 15 || @ Indians || 2–7 || Karinchak (4–2) || Harvey (3–8) || — || 12,025 || 22–44 || [https://www.mlb.com/gameday/orioles-vs-indians/2021/06/15/633769#game_state=final,game_tab=box,game=633769 L6]

|- style="background:#fbb;"

| 67 || June 16 || @ Indians || 7–8 || Civale (10–2) || Akin (0–2) || Clase (11) || 12,825 || 22–45 || [https://www.mlb.com/gameday/orioles-vs-indians/2021/06/16/633659#game_state=final,game_tab=box,game=633659 L7]

|- style="background:#fbb;"

| 68 || June 17 || @ Indians || 3–10 || Stephan (1–0) || López (2–8) || — || 15,121 || 22–46 || [https://www.mlb.com/gameday/orioles-vs-indians/2021/06/17/633641#game_state=final,game_tab=box,game=633641 L8]

|- style="background:#bfb;"

| 67 || June 18 || Blue Jays || 7–1 || T. Wells (2–0) || Ray (4–3) || — || 13,284 || 23–46 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/06/18/633593#game_state=final,game_tab=box,game=633593 W1]

|- style="background:#fbb;"

| 70 || June 19 || Blue Jays || 7–10 || Romano (4–1) || Fry (0–2) || — || 10,721 || 23–47 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/06/19/633573#game_state=final,game_tab=box,game=633573 L1]

|- style="background:#fbb;"

| 71 || June 20 || Blue Jays || 4–7 || Ryu (6–4) || Harvey (3–9) || Chatwood (1) || 14,917 || 23–48 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/06/20/633636#game_state=final,game_tab=box,game=633636 L2]

|- style="background:#fbb;"

| 72 || June 21 || Astros || 2–10 || Odorizzi (2–3) || Akin (0–3) || — || 7,414 || 23–49 || [https://www.mlb.com/gameday/astros-vs-orioles/2021/06/21/633747#game_state=final,game_tab=box,game=633747 L3]

|- style="background:#fbb;"

| 73 || June 22 || Astros || 1–3 || Greinke (8–2) || López (2–9) || Pressly (11) || 8,510 || 23–50 || [https://www.mlb.com/gameday/astros-vs-orioles/2021/06/22/633547#game_state=final,game_tab=box,game=633547 L4]

|- style="background:#fbb;"

| 74 || June 23 || Astros || 0–13 || Urquidy (6–3) || Eshelman (0–1) || — || 10,013 || 23–51 || [https://www.mlb.com/gameday/astros-vs-orioles/2021/06/23/633568#game_state=final,game_tab=box,game=633568 L5]

|- style="background:#fbb;"

| 75 || June 24 || @ Blue Jays || 0–9 || Kay (1–2) || Kremer (0–7) || — || 6,264 || 23–52 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/06/24/633560#game_state=final,game_tab=box,game=633560 L6]

|- style="background:#bfb;"

| 76 || June 25 || @ Blue Jays || 6–5 {{small|(10)}} || Fry (1–2) || Thornton (1–3) || Sulser (2) || 7,844 || 24–52 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/06/25/633536#game_state=final,game_tab=box,game=633536 W1]

|- style="background:#fbb;"

| 77 || June 26 || @ Blue Jays || 4–12 || Ryu (7–4) || Akin (0–4) || — || 5,913 || 24–53 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/06/26/633520#game_state=final,game_tab=box,game=633520 L1]

|- style="background:#fbb;"

| 78 || June 27 || @ Blue Jays || 2–5 || Stripling (3–4) || López (2–10) || Romano (6) || 6,044 || 24–54 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/06/27/633515#game_state=final,game_tab=box,game=633515 L2]

|- style="background:#bfb;"

| 79 || June 28 || @ Astros || 9–7 || Fry (2–2) || Bielak (2–3) || Plutko (1) || 24,419 || 25–54 || [https://www.mlb.com/gameday/orioles-vs-astros/2021/06/28/633483#game_state=final,game_tab=box,game=633483 W1]

|- style="background:#bfb;"

| 80 || June 29 || @ Astros || 13–3 || A. Wells (1–0) || Garza (0–2) || Tate (1) || 30,346 || 26–54 || [https://www.mlb.com/gameday/orioles-vs-astros/2021/06/29/633449#game_state=final,game_tab=box,game=633449 W2]

|- style="background:#bfb;"

| 81 || June 30 || @ Astros || 5–2 || Scott (3–3) || García (6–5) || Sulser (3) || 28,124 || 27–54 || [https://www.mlb.com/gameday/orioles-vs-astros/2021/06/30/633485#game_state=final,game_tab=box,game=633485 W3]

|-

{{Game log section end}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=July: 10–12 (Home: 5–4; Away: 5–7)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/Box}}

|- style="background:#fbb;"

| 82 || July 2 || @ Angels || 7–8 || Iglesias (5–3) || Fry (2–3) || — || 23,561 || 27–55 || [https://www.mlb.com/gameday/orioles-vs-angels/2021/07/02/633402#game_state=final,game_tab=box,game=633402 L1]

|- style="background:#fbb;"

| 83 || July 3 || @ Angels || 1–4 || Cobb (6–3) || López (2–11) || Iglesias (16) || 28,160 || 27–56 || [https://www.mlb.com/gameday/orioles-vs-angels/2021/07/03/633453#game_state=final,game_tab=box,game=633453 L2]

|- style="background:#fbb;"

| 84 || July 4 || @ Angels || 5–6 || Iglesias (6–3) || Sulser (2–1) || — || 18,955 || 27–57 || [https://www.mlb.com/gameday/orioles-vs-angels/2021/07/04/633391#game_state=final,game_tab=box,game=633391 L3]

|- style="background:#bfb;"

| 85 || July 6 || Blue Jays || 7–5 || Watkins (1–0) || Matz (7–4) || — || 7,388 || 28–57 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/07/06/633413#game_state=final,game_tab=box,game=633413 W1]

|- style="background:#fbb;"

| 86 || July 7 || Blue Jays || 2–10 || Ryu (8–5) || Harvey (3–10) || — || 7,457 || 28–58 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/07/07/633332#game_state=final,game_tab=box,game=633332 L1]

|- style="background:#bbb;"

| — || July 8 || Blue Jays || colspan=7 | Postponed (rain). Makeup date September 11 as part of doubleheader.

|- style="background:#fbb;"

| 87 || July 9 || White Sox || 1–12 || Keuchel (7–3) || López (2–12) || — || 12,077 || 28–59 || [https://www.mlb.com/gameday/white-sox-vs-orioles/2021/07/09/633377#game_state=final,game_tab=box,game=633377 L2]

|- style="background:#fbb;"

| 88 || July 10 || White Sox || 3–8 || Giolito (7–6) || Eshelman (0–2) || Hendriks (23) || 26,391 || 28–60 || [https://www.mlb.com/gameday/white-sox-vs-orioles/2021/07/10/633350#game_state=final,game_tab=box,game=633350 L3]

|- style="background:#fbb;"

| 89 || July 11 || White Sox || 5–7 {{small|(10)}} || Hendriks (4–2) || T. Wells (2–1) || Foster (1) || 11,600 || 28–61 || [https://www.mlb.com/gameday/white-sox-vs-orioles/2021/07/11/633282#game_state=final,game_tab=box,game=633282 L4]

|- bgcolor=#bbcaff

| ASG || July 13 || @ Coors Field || AL vs. NL || Ohtani (1–0) || Burnes (0–1) || Hendriks (1) || 49,184 || — || [https://www.mlb.com/gameday/al-all-stars-vs-nl-all-stars/2021/07/13/634675#game_state=final,lock_state=final,game_tab=box,game=634675 N/A]

|- style="background:#fbb;"

| 90 || July 16 || @ Royals || 2–9 || Staumont (1–2) || Akin (0–5) || — || 23,763 || 28–62 || [https://www.mlb.com/gameday/orioles-vs-royals/2021/07/16/633328#game_state=final,game_tab=box,game=633328 L5]

|- style="background:#bfb;"

| 91 || July 17 || @ Royals || 8–4 || Fry (3–3) || Singer (3–7) || — || 27,292 || 29–62 || [https://www.mlb.com/gameday/orioles-vs-royals/2021/07/17/633248#game_state=final,game_tab=box,game=633248 W1]

|- style="background:#bfb;"

| 92 || July 18 || @ Royals || 5–0 || Harvey (4–10) || Hernández (1–1) || — || 13,706 || 30–62 || [https://www.mlb.com/gameday/orioles-vs-royals/2021/07/18/633287#game_state=final,game_tab=box,game=633287 W2]

|- style="background:#bfb;"

| 93 || July 19 || @ Rays || 6–1 || Watkins (2–0) || Yarbrough (6–4) || — || 9,922 || 31–62 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/07/19/633236#game_state=final,game_tab=box,game=633236 W3]

|- style="background:#fbb;"

| 94 || July 20 || @ Rays || 3–9 || McClanahan (4–3) || Means (4–3) || — || 10,399 || 31–63 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/07/20/633257#game_state=final,game_tab=box,game=633257 L1]

|- style="background:#fbb;"

| 95 || July 21 || @ Rays || 4–5 || McHugh (3–1) || Scott (3–4) || — || 8,968 || 31–64 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/07/21/633225#game_state=final,game_tab=box,game=633225 L2]

|- style="background:#bfb;"

| 96 || July 23 || Nationals || 6–1 || Fry (4–3) || Corbin (6–9) || — || 17,022 || 32–64 || [https://www.mlb.com/gameday/nationals-vs-orioles/2021/07/23/633176#game_state=final,game_tab=box,game=633176 W1]

|- style="background:#bfb;"

| 97 || July 24 || Nationals || 5–3 || Harvey (5–10) || Lester (3–5) || Tate (2) || 30,898 || 33–64 || [https://www.mlb.com/gameday/nationals-vs-orioles/2021/07/24/633195#game_state=final,game_tab=box,game=633195 W2]

|- style="background:#bfb;"

| 98 || July 25 || Nationals || 5–4 || Sulser (3–1) || Hand (5–4) || — || 15,690 || 34–64 || [https://www.mlb.com/gameday/nationals-vs-orioles/2021/07/25/633156#game_state=final,game_tab=box,game=633156 W3]

|- style="background:#fbb;"

| 99 || July 27 || Marlins || 3–7 || Alcántara (6–9) || Watkins (2–1) || — || 10,098 || 34–65 || [https://www.mlb.com/gameday/marlins-vs-orioles/2021/07/27/633153#game_state=final,game_tab=box,game=633153 L1]

|- style="background:#bfb;"

| 100 || July 28 || Marlins || 8–7 || Scott (4–4) || Okert (0–1) || — || 8,363 || 35–65 || [https://www.mlb.com/gameday/marlins-vs-orioles/2021/07/28/633098#game_state=final,game_tab=box,game=633098 W1]

|- style="background:#fbb;"

| 101 || July 29 || @ Tigers || 2–6 || Mize (6–5) || A. Wells (1–1) || — || 15,833 || 35–66 || [https://www.mlb.com/gameday/orioles-vs-tigers/2021/07/29/633115#game_state=final,game_tab=box,game=633115 L1]

|- style="background:#bfb;"

| 102 || July 30 || @ Tigers || 4–3 || Harvey (6–10) || Skubal (6–10) || Sulser (4) || 18,861 || 36–66 || [https://www.mlb.com/gameday/orioles-vs-tigers/2021/07/30/633107#game_state=final,game_tab=box,game=633107 W1]

|- style="background:#bfb;"

| 103 || July 31 || @ Tigers || 5–2 || Means (5–3) || Manning (2–4) || Sulser (5) || 25,132 || 37–66 || [https://www.mlb.com/gameday/orioles-vs-tigers/2021/07/31/633105#game_state=final,game_tab=box,game=633105 W2]

|-

{{Game log section end}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=August: 4–24 (Home: 2–13; Away: 2–11)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/Box}}

|- style="background:#fbb;"

| 104 || August 1 || @ Tigers || 2–6 || Ramírez (1–0) || Watkins (2–2) || — || 17,134 || 37–67 || [https://www.mlb.com/gameday/orioles-vs-tigers/2021/08/01/633050#game_state=final,game_tab=box,game=633050 L1]

|- style="background:#bfb;"

| 105 || August 2 || @ Yankees || 7–1 || López (3–12) || Heaney (6–8) || — || 28,879 || 38–67 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/08/02/633078#game_state=final,game_tab=box,game=633078 W1]

|- style="background:#fbb;"

| 106 || August 3 || @ Yankees || 1–13 || Gil (1–0) || Wells (1–2) || — || 30,815 || 38–68 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/08/03/633023#game_state=final,game_tab=box,game=63302 L1]

|- style="background:#fbb;"

| 107 || August 4 || @ Yankees || 3–10 || Loáisiga (8–4) || Sulser (3–2) || — || 30,055 || 38–69 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/08/04/633018#game_state=final,game_tab=box,game=633018 L2]

|- style="background:#fbb;"

| 108 || August 6 || Rays || 6–10 || Rasmussen (1–1) || Fry (4–4) || — || 11,320 || 38–70 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/06/633006#game_state=final,game_tab=box,game=633006 L3]

|- style="background:#fbb;"

| 109 || August 7 || Rays || 3–12 || McClanahan (6–4) || Watkins (2–3) || — || 18,545 || 38–71 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/07/633014#game_state=final,game_tab=box,game=633014 L4]

|- style="background:#fbb;"

| 110 || August 8 || Rays || 6–9 || Chargois (2–0) || Fry (4–5) || — || 10,576 || 38–72 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/08/632971#game_state=final,game_tab=box,game=632971 L5]

|- style="background:#fbb;"

| 111 || August 10 || Tigers || 4–9 || Funkhouser (6–1) || Akin (0–6) || — || 7,124 || 38–73 || [https://www.mlb.com/gameday/tigers-vs-orioles/2021/08/10/632960#game_state=final,game_tab=box,game=632960 L6]

|- style="background:#fbb;"

| 112 || August 11 || Tigers || 2–5 || Skubal (8–10) || Harvey (6–11) || Soto (14) || 8,990 || 38–74 || [https://www.mlb.com/gameday/tigers-vs-orioles/2021/08/11/632922#game_state=final,game_tab=box,game=632922 L7]

|- style="background:#fbb;"

| 113 || August 12 || Tigers || 4–6 || Manning (3–5) || Means (5–4) || Fulmer (7) || 8,382 || 38–75 || [https://www.mlb.com/gameday/tigers-vs-orioles/2021/08/12/632938#game_state=final,game_tab=box,game=632938 L8]

|- style="background:#fbb;"

| 114 || August 13 || @ Red Sox || 1–8 || Pivetta (9–5) || Watkins (2–4) || Richards (1) || 28,022 || 38–76 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/08/13/632902#game_state=final,game_tab=box,game=632902 L9]

|- style="background:#fbb;"

| 115 || August 14 || @ Red Sox || 2–16 || Sale (1–0) || López (3–13) || — || 33,118 || 38–77 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/08/14/632905#game_state=final,game_tab=box,game=632905 L10]

|- style="background:#fbb;"

| 116 || August 15 || @ Red Sox || 2–6 || Rodríguez (9–6) || Akin (0–7) || — || 28,935 || 38–78 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/08/15/632961#game_state=final,game_tab=box,game=632961 L11]

|- style="background:#fbb;"

| 117 || August 16 || @ Rays || 2–9 || Fleming (10–6) || Harvey (6–12) || — || 5,460 || 38–79 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/08/16/632890#game_state=final,game_tab=box,game=632890 L12]

|- style="background:#fbb;"

| 118 || August 17 || @ Rays || 0–10 || Ellis (1–0) || Means (5–5) || — || 4,795 || 38–80 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/08/17/632864#game_state=final,game_tab=box,game=632864 L13]

|- style="background:#fbb;"

| 119 || August 18 || @ Rays || 4–8 || Yarbrough (7–4) || Watkins (2–5) || — || 6,673 || 38–81 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/08/18/632849#game_state=final,game_tab=box,game=632849 L14]

|- style="background:#fbb;"

| 120 || August 19 || @ Rays || 2–7 || McClanahan (8–4) || López (3–14) || — || 5,826 || 38–82 || [https://www.mlb.com/gameday/orioles-vs-rays/2021/08/19/632833#game_state=final,game_tab=box,game=632833 L15]

|- style="background:#fbb;"

| 121 || August 20 || Braves || 0–3 || Fried (11–7) || Akin (0–8) || — || 13,583 || 38–83 || [https://www.mlb.com/gameday/braves-vs-orioles/2021/08/20/632814#game_state=final,game_tab=box,game=632814 L16]

|- style="background:#fbb;"

| 122 || August 21 || Braves || 4–5 || Smyly (9–3) || Harvey (6–13) || Smith (27) || 15,774 || 38–84 || [https://www.mlb.com/gameday/braves-vs-orioles/2021/08/21/632879#game_state=final,game_tab=box,game=632879 L17]

|- style="background:#fbb;"

| 123 || August 22 || Braves || 1–3 || Toussaint (3–2) || Means (5–6) || Smith (28) || 11,180 || 38–85 || [https://www.mlb.com/gameday/braves-vs-orioles/2021/08/22/632772#game_state=final,game_tab=box,game=632772 L18]

|- style="background:#fbb;"

| 124 || August 24 || Angels || 8–14 || Guerra (4–2) || Watkins (2–6) || — || 8,781 || 38–86 || [https://www.mlb.com/gameday/angels-vs-orioles/2021/08/24/632807#game_state=final,game_tab=box,game=632807 L19]

|- style="background:#bfb;"

| 125 || August 25 || Angels || 10–6 || Scott (5–4) || Petricka (0–1) || — || 15,867 || 39–86 || [https://www.mlb.com/gameday/angels-vs-orioles/2021/08/25/632756#game_state=final,game_tab=box,game=632756 W1]

|- style="background:#bfb;"

| 126 || August 26 || Angels || 13–1 || Akin (1–8) || Peguero (0–1) || — || 10,211 || 40–86 || [https://www.mlb.com/gameday/angels-vs-orioles/2021/08/26/632743#game_state=final,game_tab=box,game=632743 W2]

|- style="background:#fbb;"

| 127 || August 27 || Rays || 3–6 || McClanahan (9–4) || Harvey (6–14) || Mazza (1) || 7,155 || 40–87 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/27/632720#game_state=final,game_tab=box,game=632720 L1]

|- style="background:#933;"

| 128 || August 28 || Rays || 3–4 || Chargois (4–0) || Sulser (3–3) || Kittredge (4) || 11,110 || 40–88 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/28/632721#game_state=final,game_tab=box,game=632721 L2]

|- style="background:#fbb;"

| 129 ||August 29|| Rays ||8–12|| Chargois (5–0)|| Watkins (2–7)|| — || 8,353 || 40–89 || [https://www.mlb.com/gameday/rays-vs-orioles/2021/08/29/632736#game_state=final,game_tab=box,game=632736 L3]

|- style="background:#fbb;"

| 130 || August 30 || @ Blue Jays || 3–7 || Ray (10–5) || Tate (0–4) || Romano (14) || 14,406 || 40–90 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/08/30/632668#game_state=final,game_tab=box,game=632668 L4]

|- style="background:#bfb;"

| 131 || August 31 || @ Blue Jays || 4–2 || Akin (2–8) || Ryu (12–8) || Sulser (6) || 13,963 || 41–90 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/08/31/632715#game_state=final,game_tab=box,game=632715 W1]

|-

{{Game log section end}}

{{Game log section start|hide=y|style={{Baseball secondary style|Baltimore Orioles}};|title=September/October: 11–20 (Home: 8–10; Away: 3–10)|#|Date|Opponent|Score|Win|Loss|Save|Attendance|Record|Streak/Box}}

|- style="background:#fbb;"

| 132 || September 1 || @ Blue Jays || 4–5 || Mayza (5–2) || Tate (0–5) || Romano (15) || 14,262 || 41–91 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/09/01/632640#game_state=final,game_tab=box,game=632640 L1]

|- style="background:#fbb;"

| 133 || September 3 || @ Yankees || 3–4 {{small|(10)}} || Holmes (6–2) || Tate (0–6) || — || 34,085 || 41–92 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/09/03/632642#game_state=final,game_tab=box,game=632642 L2]

|- style="background:#bfb;"

| 134 || September 4 || @ Yankees || 4–3 || Sulser (4–3) || Chapman (5–4) || — || 34,571 || 42–92 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/09/04/632622#game_state=final,game_tab=box,game=632622 W1]

|- style="background:#bfb;"

| 135 || September 5 || @ Yankees || 8–7 || Diplán (1–0) || Heaney (8–9) || T. Wells (1) || 33,091 || 43–92 || [https://www.mlb.com/gameday/orioles-vs-yankees/2021/09/05/632582#game_state=final,game_tab=box,game=632582 W2]

|- style="background:#fbb;"

| 136 || September 6 || Royals || 2–3 || Tapia (2–0) || Sulser (4–4) || Barlow (11) || 11,973 || 43–93 || [https://www.mlb.com/gameday/royals-vs-orioles/2021/09/06/632658#game_state=final,game_tab=box,game=632658 L1]

|- style="background:#bfb;"

| 137 || September 7 || Royals || 7–3 || Baumann (1–0) || Kowar (0–3) || — || 4,981 || 44–93 || [https://www.mlb.com/gameday/royals-vs-orioles/2021/09/07/632594#game_state=final,game_tab=box,game=632594 W1]

|- style="background:#bfb;"

| 138 || September 8 || Royals || 9–8 || Barreda (1–0) || Staumont (3–3) || T. Wells (2) || 4,965 || 45–93 || [https://www.mlb.com/gameday/royals-vs-orioles/2021/09/08/632576#game_state=final,game_tab=box,game=632576 W2]

|- style="background:#fbb;"

| 139 || September 9 || Royals || 0–6 || Hernández (6–1) || Means (5–7) || — || 5,087 || 45–94 || [https://www.mlb.com/gameday/royals-vs-orioles/2021/09/09/632556#game_state=final,game_tab=box,game=632556 L1]

|- style="background:#bfb;"

| 140 || September 10 || Blue Jays || 6–3 || Greene (1–0) || Merryweather (0–1) || Sulser (7) || 11,851 || 46–94 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/09/10/632563#game_state=final,game_tab=box,game=632563 W1]

|- style="background:#fbb;"

| 141 || September 11 {{small|(1)}} || Blue Jays || 10–11 || Pearson (1–1) || T. Wells (2–2) || Romano (17) || N/A || 46–95 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/09/11/632539#game_state=final,game_tab=box,game=632539 L1]

|- style="background:#fbb;"

| 142 || September 11 {{small|(2)}} || Blue Jays || 2–11 || Richards (7–2) || Akin (2–9) || — || 10,219 || 46–96 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/09/11/633331#game_state=final,game_tab=box,game=633331 L2]

|- style="background:#fbb;"

| 143 || September 12 || Blue Jays || 7–22 || Matz (12–7) || Lowther (0–2) || — || 8,474 || 46–97 || [https://www.mlb.com/gameday/blue-jays-vs-orioles/2021/09/12/632498#game_state=final,game_tab=box,game=632498 L3]

|- style="background:#fbb;"

| 144 || September 14 || Yankees || 2–7 || Cole (15–7) || A. Wells (1–3) || — || 10,235 || 46–98 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/09/14/632500#game_state=final,game_tab=box,game=632500 L4]

|- style="background:#fbb;"

| 145 || September 15 || Yankees || 3–4 || Peralta (5–3) || T. Wells (2–3) || Chapman (27) || 10,402 || 46–99 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/09/15/632494#game_state=final,game_tab=box,game=632494 L5]

|- style="background:#bfb;"

| 146 || September 16 || Yankees || 3–2 {{small|(10)}} || Sulser (5–4) || Peralta (5–4) || — || 20,164 || 47–99 || [https://www.mlb.com/gameday/yankees-vs-orioles/2021/09/16/632452#game_state=final,game_tab=box,game=632452 W1]

|- style="background:#fbb;"

| 147 || September 17 || @ Red Sox || 1–7 || Sale (4–0) || Akin (2–10) || — || 29,811 || 47–100 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/09/17/632454#game_state=final,game_tab=box,game=632454 L1]

|- style="background:#fbb;"

| 148 || September 18 || @ Red Sox || 3–9 || Houck (1–4) || Baumann (1–1) || — || 30,027 || 47–101 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/09/18/632451#game_state=final,game_tab=box,game=632451 L2]

|- style="background:#fbb;"

| 149 || September 19 || @ Red Sox || 6–8 || Sawamura (5–1) || Greene (1–1) || Richards (3) || 27,010 || 47–102 || [https://www.mlb.com/gameday/orioles-vs-red-sox/2021/09/19/632419#game_state=final,game_tab=box,game=632419 L3]

|- style="background:#bfb;"

| 150 || September 20 || @ Phillies || 2–0 || Means (6–7) || Suárez (6–5) || T. Wells (3) || 21,440 || 48–102 || [https://www.mlb.com/gameday/orioles-vs-phillies/2021/09/20/632429#game_state=final,game_tab=box,game=632429 W1]

|- style="background:#fbb;"

| 151 || September 21 || @ Phillies || 2–3 {{small|(10)}} || Kennedy (3–1) || Valdez (2–2) || — || 18,955 || 48–103 || [https://www.mlb.com/gameday/orioles-vs-phillies/2021/09/21/632402#game_state=final,game_tab=boxscore,game=632402 L1]

|- style="background:#fbb;"

| 152 || September 22 || @ Phillies || 3–4 || Alvarado (7–1) || Greene (1–2) || Kennedy (25) || 18,133 || 48–104 || [https://www.mlb.com/gameday/orioles-vs-phillies/2021/09/22/632382#game_state=final,game_tab=box,game=632382 L2]

|- style="background:#bfb;"

| 153 || September 23 || Rangers || 3–0 || Lowther (1–2) || Otto (0–3) || T. Wells (4) || 6,328 || 49–104 || [https://www.mlb.com/gameday/rangers-vs-orioles/2021/09/23/632390#game_state=final,game_tab=box,game=632390 W1]

|- style="background:#fbb;"

| 154 || September 24 || Rangers || 5–8 || Sborz (4–3) || Greene (1–3) || Barlow (8) || 7,935 || 49–105 || [https://www.mlb.com/gameday/rangers-vs-orioles/2021/09/24/632369#game_state=final,game_tab=box,game=632369 L1]

|- style="background:#bfb;"

| 155 || September 25 || Rangers || 3–2 || Kriske (2–1) || Lyles (9–13) || Tate (3) || 10,645 || 50–105 || [https://www.mlb.com/gameday/rangers-vs-orioles/2021/09/25/632355#game_state=final,game_tab=boxscore,game=632355 W1]

|- style="background:#fbb;"

| 156 || September 26 || Rangers || 4–7 || Cotton (2–0) || Means (6–8) || Barlow (9) || 13,495 || 50–106 || [https://www.mlb.com/gameday/rangers-vs-orioles/2021/09/26/632334#game_state=final,game_tab=box,game=632334 L1]

|- style="background:#bfb;"

| 157 || September 28 || Red Sox || 4–2 || Diplán (2–0) || Sale (5–1) || Sulser (8) || 8,098 || 51–106 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/09/28/632317#game_state=final,game_tab=box,game=632317 W1]

|- style="background:#fbb;"

| 158 || September 29 || Red Sox || 0–6 || Eovaldi (11–9) || Lowther (1–3) || — || 8,732 || 51–107 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/09/29/632309#game_state=final,game_tab=box,game=632309 L1]

|- style="background:#bfb;"

| 159 || September 30 || Red Sox || 6–2 || A. Wells (2–3) || Pivetta (9–8) || — || 13,012 || 52–107 || [https://www.mlb.com/gameday/red-sox-vs-orioles/2021/09/30/632294#game_state=final,game_tab=box,game=632294 W1]

|- style="background:#fbb;"

| 160 || October 1 || @ Blue Jays || 4–6 || Matz (14–7) || Eshelman (0–3) || Romano (23) || 28,855 || 52–108 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/10/01/632268#game_state=final,game_tab=box,game=632268 L1]

|- style="background:#fbb;"

| 161 || October 2 || @ Blue Jays || 1–10 || Manoah (9–2) || Means (6–9) || — || 29,916 || 52–109 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/10/02/632247#game_state=final,game_tab=box,game=632247 L2]

|- style="background:#fbb;"

| 162 || October 3 || @ Blue Jays || 4–12 || Ryu (14–10) || Zimmermann (4–5) || — || 29,942 || 52–110 || [https://www.mlb.com/gameday/orioles-vs-blue-jays/2021/10/03/632235#game_state=final,game_tab=box,game=632235 L3]

|-

{{Game log section end}}

{{Game log end}}

{{notelist}}

Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average

Source:[https://baseball-reference.com/teams/BAL/2021-batting.shtml]

Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts

Source:[https://baseball-reference.com/teams/BAL/2021-pitching.shtml]

• John Means pitched a complete game no hitter, defeating the Seattle Mariners 6–0 on May 5.{{Cite web|title=Masterful Means no-hits Mariners in Seattle|url=https://www.mlb.com/news/john-means-throws-no-hitter|access-date=2021-05-05|website=MLB.com|language=en}}

{{See also|Minor League Baseball}}

{{MLB Farm System

|level1 = Triple-A

|team1 = Norfolk Tides

|league1 = Triple-A East

|manager1 = Gary Kendall

|level2 = Double-A

|team2 = Bowie Baysox

|league2 = Double-A Northeast

|manager2 = Buck Britton

|level3 = High-A

|team3 = Aberdeen IronBirds

|league3 = High-A East

|manager3 = Kyle Moore

|level4 = Low-A

|team4 = Delmarva Shorebirds

|league4 = Low-A East

|manager4 = Dave Anderson

|level5 = Rookie

|team5 = FCL Orioles Orange

|league5 = Florida Complex League

|manager5 = Kevin Bradshaw

|level6 = Rookie

|team6 = FCL Orioles Black

|league6 = Florida Complex League

|manager6 = Alan Mills

|level7 = Foreign Rookie

|team7 = DSL Orioles 1

|league7 = Dominican Summer League

|manager7 = Elvis Morel

|level8 = Foreign Rookie

|team8 = DSL Orioles 2

|league8 = Dominican Summer League

|manager8 = Chris Madera

}}

{{Reflist}}

• [https://www.mlb.com/orioles/schedule/2021/fullseason Baltimore Orioles 2021 schedule] at MLB.com
• [https://www.baseball-reference.com/teams/BAL/2021.shtml 2021 Baltimore Orioles season at Baseball Reference]

{{2021 MLB season by team}}

{{Baltimore Orioles}}

Category:Baltimore Orioles seasons

Baltimore Orioles

Baltimore Orioles

Category:2021 in Baltimore