Daniel Trachsel
{{Short description|Swiss chemist}}
{{Infobox person
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| alma_mater = Burgdorf University of Applied Sciences
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| years_active = 1993–present
| organization = ReseaChem
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| notable_works = Psychedelische Chemie Aspekte psychoaktiver Moleküle (2000); Phenethylamine: von der Struktur zur Funktion (2013)
| website = https://nachtschatten.ch/autoren/trachsel/
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Daniel Trachsel is a Swiss chemist who studies psychedelics and entactogens.{{cite journal | vauthors = Passie T, Brandt SD | title = Self-Experiments with Psychoactive Substances: A Historical Perspective | journal = Handb Exp Pharmacol | volume = 252 | issue = | pages = 69–110 | date = 2018 | pmid = 30478735 | doi = 10.1007/164_2018_177 | url = https://is-sp.org/fileadmin/user_upload/passie_brandt_self-experiments_w_psychoactive_substances_2018.pdf | quote = One follower of Shulgin’s research can be seen in the Swiss chemist Daniel Trachsel, who published various contributions on many new psychoactive substances and their effects (Trachsel 2011, 2012; Trachsel et al. 2013). Experimental results about their psychoactive effects are included, but the author distanced himself from any [self-experiments (SEs)] (Trachsel 2011, p. 12). }}{{cite podcast | url=https://www.patreon.com/posts/podcast-34-four-59224393 | title=PODCAST 34: A Four Hour Interview with Dr. David E Nichols | website=The Hamilton Morris Podcast | publisher=Patreon | host=Hamilton Morris | date=27 November 2021 | time= | access-date=30 January 2025 }} He has developed and published on a large number of novel psychedelic and entactogen compounds, including their psychoactive effects.{{cite journal | vauthors = Halberstadt AL, Chatha M, Klein AK, Wallach J, Brandt SD | title = Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species | journal = Neuropharmacology | volume = 167 | issue = | pages = 107933 | date = May 2020 | pmid = 31917152 | pmc = 9191653 | doi = 10.1016/j.neuropharm.2019.107933 | url = | quote = The human potency data used in the analysis (Table 4) were collected from several sources, including clinical trials, results published by Dr. Alexander Shulgin and Dr. Daniel Trachsel, as well as from websites such as erowid.com and psychonautwiki.org. }} This has been in a manner similar to that of the psychedelic chemist Alexander Shulgin, which has caused Trachsel to sometimes be referred to as the "German Shulgin". However, unlike Shulgin, Trachsel has distanced himself from any personal self-experiments.
According to Hamilton Morris and Nick Cozzi in mid-2023, Trachel's book Phenethylamine: von der Struktur zur Funktion (Phenethylamines: From Structure to Function) is in the process of being translated into English.{{cite podcast | url=https://www.patreon.com/posts/86620808 | title=POD 81: Dr. Carl Hart and Dr. Nicholas Cozzi at the MAPS conference | website=The Hamilton Morris Podcast | publisher=Patreon | host=Hamilton Morris | date=25 July 2023 | time=1:17:57}} It is being independently translated by the Alexander Shulgin Research Institute (ASRI), with tentative publication by Transform Press, and also by chemist David Carlson.
Compounds
Selected publications
=Books=
- {{cite book | last1=Trachsel | first1=D. | last2=Richard | first2=N. | title=Psychedelische Chemie Aspekte psychoaktiver Moleküle | trans-title = Psychedelic Chemistry: Aspects of Psychoactive Molecules | edition=1 | publisher=Nachtschatten-Verlag | year=2000 | isbn=978-3-907080-53-5 | oclc=247657972 | url=https://books.google.com/books?id=xPAiAAAACAAJ | language=de | access-date=31 January 2025 }} [Note: There are also several subsequent editions (2nd (2002) through 5th (2016)).]{{cite web | title=Psychedelische Chemie [Psychedelic Chemistry] Formats and Editions | website=WorldCat.org | publisher = WorldCat | url=https://search.worldcat.org/formats-editions/45813487 | access-date=31 January 2025}}
- {{cite book | last1=Trachsel | first1=D. | last2=Lehmann | first2=D. | last3=Enzensperger | first3=C. | title=Phenethylamine: von der Struktur zur Funktion | trans-title = Phenethylamines: From Structure to Function | edition = 1 | publisher=Nachtschatten-Verlag | location = Solothurn | series=Nachtschatten-Science | year=2013 | isbn=978-3-03788-700-4 | oclc = 858805226 | url=https://books.google.com/books?id=-Us1kgEACAAJ | language=de | access-date=31 January 2025 }}
=Papers=
- {{cite journal | last=Trachsel | first=Daniel | title=Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate | trans-title=Synthesis of new (phenylalkyl)amines for the investigation of structure-activity relationships, Communication 1, Mescaline derivatives | journal=Helvetica Chimica Acta | volume=85 | issue=9 | date=2002 | doi=10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4 | pages=3019–3026 | url=https://www.erowid.org/archive/rhodium/pdf/mescaline.4-subst.analogs.pdf }}
- {{cite journal | last=Trachsel | first=Daniel | title=Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine) | trans-title=Synthesis of new (phenylalkyl)amines for the investigation of structure–activity relationships. Communication 2: 4-thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzenethanamines) | journal=Helvetica Chimica Acta | volume=86 | issue=7 | date=2003 | issn=0018-019X | doi=10.1002/hlca.200390210 | pages=2610–2619}}
- {{cite journal | last=Trachsel | first=Daniel | title=Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships, Part 3: 4-Ethynyl-2,5-dimethoxyphenethylamine (=4-Ethynyl-2,5-dimethoxybenzeneethanamine; 2C-YN) | journal=Helvetica Chimica Acta | volume=86 | issue=8 | date=2003 | issn=0018-019X | doi=10.1002/hlca.200390224 | pages=2754–2759 | url=https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=d2590ac2d869b835a7e83a2af745ac2558195797 | url-access=subscription }}
- {{cite journal | vauthors = Trachsel D, Hadorn M, Baumberger F | title = Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives | journal = Chem Biodivers | volume = 3 | issue = 3 | pages = 326–336 | date = March 2006 | pmid = 17193269 | doi = 10.1002/cbdv.200690035 | url = https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=820d672ead44ebea16bdd50b67b74393b4d0c8d4 | url-access = subscription }}
- {{cite journal | vauthors = Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F | title = 4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities | journal = Chem Biodivers | volume = 6 | issue = 5 | pages = 692–704 | date = May 2009 | pmid = 19479848 | doi = 10.1002/cbdv.200800235 | url = https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=a90cbe831343059d0ca8f4bc7497b57f0cef6fc5 | url-access = subscription }}
- {{cite journal | vauthors = Trachsel D | title = Fluorine in psychedelic phenethylamines | journal = Drug Test Anal | volume = 4 | issue = 7–8 | pages = 577–590 | date = 2012 | pmid = 22374819 | doi = 10.1002/dta.413 | url = https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=c7b41be36b1f580a264a752521d151e6e2d9409d | url-access = subscription }}
- {{cite journal | vauthors = Luethi D, Trachsel D, Hoener MC, Liechti ME | title = Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) | journal = Neuropharmacology | volume = 134 | issue = Pt A | pages = 141–148 | date = May 2018 | pmid = 28720478 | doi = 10.1016/j.neuropharm.2017.07.012 | url = https://edoc.unibas.ch/57358/1/20170920150712_59c2680084ec5.pdf }}
- {{cite journal | vauthors = Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME | title = Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines | journal = Front Pharmacol | volume = 12 | issue = | pages = 794254 | date = 2021 | pmid = 35222010 | pmc = 8865417 | doi = 10.3389/fphar.2021.794254 | doi-access = free | url = https://edoc.unibas.ch/87985/1/fphar-12-794254.pdf }}
- {{cite journal | vauthors = Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME | title = Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines | journal = Psychopharmacology (Berl) | volume = 240 | issue = 1 | pages = 115–126 | date = January 2023 | pmid = 36477925 | doi = 10.1007/s00213-022-06279-2 | pmc = 9816194 | url = https://researchonline.ljmu.ac.uk/id/eprint/18166/8/Use%20of%20the%20head-twitch%20response%20to%20investigate%20the%20structure-activity%20relationships%20of%204-thio-substituted%202,5-dimethoxyphenylalkylamines.pdf }}
See also
References
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Category:Psychedelic drug researchers