class="wikitable sortable" |
Year
! class="unsortable" | Portrait
! style="width:150px" | Laureate{{ref label|Note1|a|a}}
! style="width:150px" | Country{{ref label|Note2|b|b}}
! class="unsortable"| Rationale{{ref label|Note3|c|c}} |
---|
rowspan=3 | 2004{{ref label|Note4|d|d}}
| 100px
| data-sort-value="Cohen"|Stanley N. Cohen
| {{USA}}
| rowspan=2 | For their discoveries on DNA cloning and genetic engineering.[{{cite web |title=The 2004 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2004 |publisher=Shaw Prize Foundation |access-date=1 October 2022 |archive-url=https://web.archive.org/web/20221001161753/https://www.shawprize.org/laureates/life-science-medicine/2004 |archive-date=1 October 2022}}] |
100px
| data-sort-value="Boyer"|Herbert W. Boyer
| {{USA}} |
| data-sort-value="Kan"|Yuet-Wai Kan
| {{USA}}
| For his discoveries on DNA polymorphism and its influence on human genetics. |
2004{{ref label|Note4|d|d}}
| 100px
| data-sort-value="Doll"|Richard Doll
| {{GBR}}
| For his contribution to modern cancer epidemiology. |
2005
|
| data-sort-value="Berridge"|Michael Berridge
| {{GBR}}
| For his discoveries on calcium signalling in the regulation of cellular activity.[{{cite web |title=The 2005 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2005 |publisher=Shaw Prize Foundation |access-date=1 October 2022 |archive-url=https://web.archive.org/web/20221001162956/https://www.shawprize.org/laureates/life-science-medicine/2005 |archive-date=1 October 2022}}][{{cite news |url=http://www.babraham.org/news2005/july-19.html |title=$1 million 'Nobel of the East' awarded to Sir Michael Berridge, Emeritus Fellow at the Babraham Institute |date=18 July 2005 |publisher=Babraham Institute |access-date=31 October 2009 |archive-url=https://web.archive.org/web/20110725030025/http://www.babraham.org/news2005/july-19.html |archive-date=25 July 2011}}] |
2006
|
| data-sort-value="Wang"|Xiaodong Wang
| {{USA}}
| For his discovery of the biochemical basis of programmed cell death, a vital process that balances cell birth and defends against cancer.[{{cite web |title=The 2006 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2006 |publisher=Shaw Prize Foundation |access-date=3 October 2022 |archive-url=https://web.archive.org/web/20221003141808/https://www.shawprize.org/laureates/life-science-medicine/2006 |archive-date=3 October 2022}}][{{cite news |url=https://www.hhmi.org/news/xiaodong-wang-wins-1-million-shaw-prize |title=Xiaodong Wang Wins $1 Million Shaw Prize |date=22 June 2006 |publisher=Howard Hughes Medical Institute |access-date=20 April 2015 |archive-url=https://web.archive.org/web/20150420054751/https://www.hhmi.org/news/xiaodong-wang-wins-1-million-shaw-prize |archive-date=20 April 2015}}] |
2007
| 100px
| data-sort-value="Lefkowitz"|Robert Lefkowitz
| {{USA}}
| For his relentless elucidation of the major receptor system that mediates the response of cells and organs to drugs and hormones.[{{cite web |title=The 2007 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2007 |publisher=Shaw Prize Foundation |access-date=3 October 2022 |archive-url=https://web.archive.org/web/20221003142113/https://www.shawprize.org/laureates/life-science-medicine/2007 |archive-date=3 October 2022}}][{{cite magazine |title=Shaw Prize In Life Sciences To Lefkowitz |date=16 July 2007 |url=https://cen.acs.org/articles/85/i29/Shaw-Prize-Life-Sciences-Lefkowitz.html |magazine=Chemical & Engineering News |volume=85 |issue=29 |archive-url=https://web.archive.org/web/20221003142357/https://cen.acs.org/articles/85/i29/Shaw-Prize-Life-Sciences-Lefkowitz.html |archive-date=3 October 2022 |access-date=3 October 2022}}] |
rowspan=3 | 2008{{ref label|Note5|e|e}}
|
| data-sort-value="Campbell"|Keith H. S. Campbell
| {{GBR}}
| rowspan=3 | For their recent pivotal innovations in reversing the process of cell differentiation in mammals, a phenomenon which advances our knowledge of developmental biology and holds great promise for the treatment of human diseases and improvements in agriculture practices.[{{cite web |title=The 2008 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2008 |publisher=Shaw Prize Foundation |access-date=3 October 2022 |archive-url=https://web.archive.org/web/20221003142924/https://www.shawprize.org/laureates/life-science-medicine/2008 |archive-date=3 October 2022}}][{{cite news |title=Shinya Yamanaka's Road to the 2012 Nobel Prize in Medicine |url=https://www.ucsf.edu/news/2012/10/104367/shinya-yamanakas-road-2012-nobel-prize-medicine |access-date=3 October 2022 |publisher=University of California, San Francisco |date=8 October 2012 |archive-url=https://web.archive.org/web/20221003143545/https://www.ucsf.edu/news/2012/10/104367/shinya-yamanakas-road-2012-nobel-prize-medicine |archive-date=3 October 2022}}] |
| data-sort-value="Wilmut"|Ian Wilmut
| {{GBR}} |
100px
| data-sort-value="Yamanaka"|Shinya Yamanaka
| {{JPN}} |
rowspan=2 | 2009
|
| data-sort-value="Coleman"|Douglas L. Coleman
| {{USA}}
| rowspan=2 | For their work leading to the discovery of leptin, a hormone that regulates food intake and body weight.[{{cite web |title=The 2009 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2009 |publisher=Shaw Prize Foundation |access-date=3 October 2022 |archive-url=https://web.archive.org/web/20221003143918/https://www.shawprize.org/laureates/life-science-medicine/2009 |archive-date=3 October 2022}}][{{cite news |title=Canadian, U.S. scientists win $1M Shaw prize for obesity work |url=https://www.cbc.ca/news/science/canadian-u-s-scientists-win-1m-shaw-prize-for-obesity-work-1.784784 |access-date=3 October 2022 |work=Canadian Broadcasting Corporation |date=16 June 2009 |archive-url=https://web.archive.org/web/20221003144531/https://www.cbc.ca/news/science/canadian-u-s-scientists-win-1m-shaw-prize-for-obesity-work-1.784784 |archive-date=3 October 2022}}] |
100px
| data-sort-value="Friedman"|Jeffrey M. Friedman
| {{USA}} |
2010
| 100px
| data-sort-value="Julius"|David Julius
| {{USA}}
| For his seminal discoveries of molecular mechanisms by which the skin senses painful stimuli and temperature and produces pain hypersensitivity.[{{cite web |title=The 2010 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2010 |publisher=Shaw Prize Foundation |access-date=3 October 2022 |archive-url=https://web.archive.org/web/20221003144724/https://www.shawprize.org/laureates/life-science-medicine/2010 |archive-date=3 October 2022}}][{{cite news |title=Julius Named to Receive the Shaw Prize |url=https://www.ucsf.edu/news/2010/05/101184/julius-named-receive-shaw-prize |access-date=3 October 2022 |publisher=University of California, San Francisco |date=27 May 2010 |archive-url=https://web.archive.org/web/20221003145220/https://www.ucsf.edu/news/2010/05/101184/julius-named-receive-shaw-prize |archive-date=3 October 2022}}] |
rowspan=3 | 2011
| 100px
| data-sort-value="Hoffmann"|Jules A. Hoffmann
| {{FRA}}
| rowspan=3 | For their discovery of the molecular mechanism of innate immunity, the first line of defense against pathogens.[{{cite web |title=The 2011 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2011 |publisher=Shaw Prize Foundation |access-date=4 October 2022 |archive-url=https://web.archive.org/web/20221004141024/https://www.shawprize.org/laureates/life-science-medicine/2011 |archive-date=4 October 2022}}][{{cite journal |title=Shaw Prize awarded to immunobiologist |journal=Yale Medicine Magazine |date=2012 |issue=2012 Winter |url=https://medicine.yale.edu/news/yale-medicine-magazine/article/shaw-prize-awarded-to-immunobiologist/ |access-date=4 October 2022 |archive-url=https://web.archive.org/web/20221004142033/https://medicine.yale.edu/news/yale-medicine-magazine/article/shaw-prize-awarded-to-immunobiologist/ |archive-date=4 October 2022}}] |
| data-sort-value="Medzhitov"|Ruslan M. Medzhitov
| {{USA}} |
100px
| data-sort-value="Beutler"|Bruce A. Beutler
| {{USA}} |
rowspan=2 | 2012
|
| data-sort-value="Hartl"|Franz-Ulrich Hartl
| {{GER}}
| rowspan=2 | For their contributions to the understanding of the molecular mechanism of protein folding. Proper protein folding is essential for many cellular functions.[{{cite web |title=The 2012 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2012 |publisher=Shaw Prize Foundation |access-date=4 October 2022 |archive-url=https://web.archive.org/web/20221004142331/https://www.shawprize.org/laureates/life-science-medicine/2012 |archive-date=4 October 2022}}][{{cite news |title=Horwich and Hartl Awarded Shaw Prize |url=https://www.hhmi.org/news/horwich-and-hartl-awarded-shaw-prize |access-date=4 October 2022 |publisher=Howard Hughes Medical Institute |date=29 May 2012 |archive-url=https://web.archive.org/web/20221004142611/https://www.hhmi.org/news/horwich-and-hartl-awarded-shaw-prize |archive-date=4 October 2022}}] |
100px
| data-sort-value="Horwich"|Arthur L. Horwich
| {{USA}} |
rowspan=3 | 2013
| 100px
| data-sort-value="Hall"|Jeffrey C. Hall
| {{USA}}
| rowspan=3 | For their discovery of molecular mechanisms underlying circadian rhythms.[{{cite web |title=The 2013 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2013 |publisher=Shaw Prize Foundation |access-date=4 October 2022 |archive-url=https://web.archive.org/web/20221004142753/https://www.shawprize.org/laureates/life-science-medicine/2013 |archive-date=4 October 2022}}][{{cite news |title=Rosbash, Hall and Young awarded Shaw Prize |url=https://www.brandeis.edu/now/2013/may/rosbash.html |access-date=4 October 2022 |publisher=Brandeis University |date=30 May 2013 |archive-url=https://web.archive.org/web/20221004143048/https://www.brandeis.edu/now/2013/may/rosbash.html |archive-date=4 October 2022}}] |
100px
| data-sort-value="Rosbash"|Michael Rosbash
| {{USA}} |
100px
| data-sort-value="Young"|Michael W. Young
| {{USA}} |
rowspan=2 | 2014
| 100px
| data-sort-value="Mori"|Kazutoshi Mori
| {{JAP}}
| rowspan=2 | For their discovery of the Unfolded Protein Response of the endoplasmic reticulum, a cell signalling pathway that controls organelle homeostasis and quality of protein export in eukaryotic cells.[{{cite web |title=The 2014 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2014 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005020912/https://www.shawprize.org/laureates/life-science-medicine/2014 |archive-date=5 October 2022}}][{{cite news |last1=Leuty |first1=Ron |title=Cellular 'life or death' switch nets $1 million prize for UCSF researcher |url=https://www.bizjournals.com/sanfrancisco/blog/biotech/2014/05/shaw-prize-ucsf-kyoto-peter-walter-kazutoshi-mori.html |access-date=5 October 2022 |work=San Francisco Business Journal |date=27 May 2014 |archive-url=https://web.archive.org/web/20221005021445/https://www.bizjournals.com/sanfrancisco/blog/biotech/2014/05/shaw-prize-ucsf-kyoto-peter-walter-kazutoshi-mori.html |archive-date=5 October 2022}}] |
100px
| data-sort-value="Walter"|Peter Walter
| {{USA}} |
rowspan=2 | 2015
| 100px
| data-sort-value="Bassler"|Bonnie L. Bassler
| {{USA}}
| rowspan=2 | For elucidating the molecular mechanism of quorum sensing, a process whereby bacteria communicate with each other and which offers innovative ways to interfere with bacterial pathogens or to modulate the microbiome for health applications.[{{cite web |title=The 2015 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2015 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005021900/https://www.shawprize.org/laureates/life-science-medicine/2015 |archive-date=5 October 2022}}][{{cite news |title=The Shaw Prize awarded to E. Peter Greenberg and Bonnie Bassler (Princeton) in Life Science and Medicine |url=https://www.washington.edu/research/announcements/the-shaw-prize-awarded-to-e-peter-greenberg-and-bonnie-bassler-princeton-in-life-science-and-medicine/ |access-date=5 October 2022 |publisher=University of Washington |date=17 June 2015 |archive-url=https://web.archive.org/web/20221005022341/https://www.washington.edu/research/announcements/the-shaw-prize-awarded-to-e-peter-greenberg-and-bonnie-bassler-princeton-in-life-science-and-medicine/ |archive-date=5 October 2022}}] |
| data-sort-value="Greenberg"|E. Peter Greenberg
| {{USA}} |
rowspan=2 | 2016
| 100px
| data-sort-value="Bird"|Adrian P. Bird
| {{GBR}}
| rowspan=2 | For their discovery of the genes and the encoded proteins that recognize one chemical modification of the DNA of chromosomes that influences gene control as the basis of the developmental disorder Rett syndrome.[{{cite web |title=The 2016 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2016 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005023025/https://www.shawprize.org/laureates/life-science-medicine/2016 |archive-date=5 October 2022}}][{{cite news |last1=Almond |first1=B. J. |title=Trustee Huda Zoghbi wins Shaw Prize |url=http://news2.rice.edu/2016/05/31/trustee-huda-zoghbi-wins-shaw-prize/ |access-date=5 October 2022 |publisher=Rice University |date=31 May 2016 |archive-url=https://web.archive.org/web/20221005023721/http://news2.rice.edu/2016/05/31/trustee-huda-zoghbi-wins-shaw-prize/ |archive-date=5 October 2022}}] |
100px
| data-sort-value="Zoghbi"|Huda Y. Zoghbi
| {{USA}} |
rowspan=2 | 2017
| 100px
| data-sort-value="Gibbons"|Ian R. Gibbons
| {{USA}}
| rowspan=2 | For their discovery of microtubule-associated motor proteins: engines that power cellular and intracellular movements essential to the growth, division, and survival of human cells.[{{cite web |title=The 2017 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2017 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005024120/https://www.shawprize.org/laureates/life-science-medicine/2017 |archive-date=5 October 2022}}][{{cite news |last1=Sanders |first1=Robert |title=Ian Gibbons awarded Shaw Prize for discovery of molecular motors |url=https://news.berkeley.edu/2017/05/25/ian-gibbons-awarded-shaw-prize-for-discovery-of-molecular-motors/ |access-date=5 October 2022 |publisher=University of California, Berkeley |date=25 May 2017 |archive-url=https://web.archive.org/web/20221005024455/https://news.berkeley.edu/2017/05/25/ian-gibbons-awarded-shaw-prize-for-discovery-of-molecular-motors/ |archive-date=5 October 2022}}] |
100px
| data-sort-value="Vale"|Ronald D. Vale
| {{USA}} |
2018
| 100px
| data-sort-value="King"|Mary-Claire King
| {{USA}}
| For her mapping the first breast cancer gene. Using mathematical modeling, King predicted and then demonstrated that breast cancer can be caused by a single gene. She mapped the gene which facilitated its cloning and has saved thousands of lives.[{{cite web |title=The 2018 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2018 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005025141/https://www.shawprize.org/laureates/life-science-medicine/2018 |archive-date=5 October 2022}}][{{cite news |title=Geneticist Mary-Claire King to receive Shaw Prize in China |url=https://newsroom.uw.edu/postscript/mary-claire-king-receive-shaw-prize-china |access-date=5 October 2022 |publisher=University of Washington |date=14 May 2018 |archive-url=https://web.archive.org/web/20221005030035/https://newsroom.uw.edu/postscript/mary-claire-king-receive-shaw-prize-china |archive-date=5 October 2022}}] |
2019
|
| data-sort-value="Jasin"|Maria Jasin
| {{USA}}
| For her work showing that localized double strand breaks in DNA stimulate recombination in mammalian cells. This seminal work was essential for and led directly to the tools enabling editing at specific sites in mammalian genomes.[{{cite web |title=The 2019 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2019 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005025421/https://www.shawprize.org/laureates/life-science-medicine/2019 |archive-date=5 October 2022}}][{{cite news |title=World-Renowned Molecular Biologist Maria Jasin Wins the Shaw Prize in Life Science and Medicine |url=https://www.mskcc.org/news/world-renowned-developmental-biologist-maria-jasin-wins-shaw-prize-life-science-and-medicine |access-date=5 October 2022 |publisher=Memorial Sloan Kettering Cancer Center |date=21 May 2019 |archive-url=https://web.archive.org/web/20221005030155/https://www.mskcc.org/news/world-renowned-developmental-biologist-maria-jasin-wins-shaw-prize-life-science-and-medicine |archive-date=5 October 2022}}] |
rowspan=3 | 2020
| 100px
| data-sort-value="Miesenböck"|Gero Miesenböck
| {{AUT}}
| rowspan=3 | For the development of optogenetics, a technology that has revolutionized neuroscience.[{{cite web |title=The 2020 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2020 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005030452/https://www.shawprize.org/laureates/life-science-medicine/2020 |archive-date=5 October 2022}}][{{cite news |title=Peter Hegemann receives 2020 Shaw Prize |url=https://www.ecn-berlin.de/news-reader/peter-hegemann-receives-2020-shaw-price.html |access-date=5 October 2022 |publisher=Einstein Center for Neurosciences Berlin |date=25 May 2020 |archive-url=https://web.archive.org/web/20221005031018/https://www.ecn-berlin.de/news-reader/peter-hegemann-receives-2020-shaw-price.html |archive-date=5 October 2022}}] |
100px
| data-sort-value="Hegemann"|Peter Hegemann
| {{GER}} |
100px
| data-sort-value="Nagel"|Georg Nagel
| {{GER}} |
2021
| 100px
| data-sort-value="Emr"|Scott D. Emr
| {{USA}}
| For the landmark discovery of the ESCRT (Endosomal Sorting Complex Required for Transport) pathway, which is essential in diverse processes involving membrane biology, including cell division, cell-surface receptor regulation, viral dissemination, and nerve axon pruning. These processes are central to life, health and disease.[{{cite web |title=The 2021 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2021 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005032034/https://www.shawprize.org/laureates/life-science-medicine/2021 |archive-date=5 October 2022}}][{{cite news |last1=Blackwood |first1=Kate |title=Emr wins $1.2M Shaw Prize in Life Science and Medicine |url=https://news.cornell.edu/stories/2021/06/emr-wins-12m-shaw-prize-life-science-and-medicine |access-date=5 October 2022 |publisher=Cornell University |date=1 June 2021 |archive-url=https://web.archive.org/web/20221005032047/https://news.cornell.edu/stories/2021/06/emr-wins-12m-shaw-prize-life-science-and-medicine |archive-date=5 October 2022}}] |
rowspan=2 | 2022
|
| data-sort-value="Negulescu"|Paul A. Negulescu
| {{USA}}
| rowspan=2 | For landmark discoveries of the molecular, biochemical, and functional defects underlying cystic fibrosis and the identification and development of medicines that reverse those defects and can treat most people affected by this disorder. Together, these discoveries and medicines are alleviating human suffering and saving lives.[{{cite web |title=The 2022 Prize in Life Science & Medicine |url=https://www.shawprize.org/laureates/life-science-medicine/2022 |publisher=Shaw Prize Foundation |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005032240/https://www.shawprize.org/laureates/life-science-medicine/2022 |archive-date=5 October 2022}}][{{cite news |title=Welsh wins 2022 Shaw Prize in Life Sciences and Medicine |url=https://medicine.uiowa.edu/content/welsh-wins-2022-shaw-prize-life-sciences-and-medicine |access-date=5 October 2022 |publisher=Roy J. and Lucille A. Carver College of Medicine, University of Iowa |date=25 May 2022 |archive-url=https://web.archive.org/web/20221005032645/https://medicine.uiowa.edu/content/welsh-wins-2022-shaw-prize-life-sciences-and-medicine |archive-date=5 October 2022}}] |
| data-sort-value="Welsh"|Michael J. Welsh
| {{USA}} |
rowspan=2 | 2023
|100px
| data-sort-value="Cramer"|Patrick Cramer
| {{GER}}
| rowspan=2 | For pioneering structural biology that enabled visualisation, at the level of individual atoms, of the protein machines responsible for gene transcription, one of life's fundamental processes. They revealed the mechanism underlying each step in gene transcription, how proper gene transcription promotes health, and how dysregulation causes disease. |
100px
| data-sort-value="Nogales"|Eva Nogales
| {{ESP}} & {{USA}} |
rowspan=2 | 2024
|
| data-sort-value="Orkin"|Stuart H. Orkin
| {{USA}}
| rowspan=2 | For their discovery of the genetic and molecular mechanisms underlying the fetal-to-adult hemoglobin switch, making possible a revolutionary and highly effective genome-editing therapy for sickle cell anemia and β thalassemia, devastating blood diseases that affect millions of people worldwide. |
100px
| data-sort-value="Thein"|Swee Lay Thein
| {{USA}} |