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I live in Ekaterinburg, Russia. As of 2019, I'm a freelance translator specializing in biochem, biotech and pharma. My interests include psychiatry and neuroscience. And history of Russia.

I love the music of Bob Dylan, Boris Grebenshikov (Aquarium), Frank Zappa, Chumbawamba, Umka and Beethoven's string quartets.

I enjoy skiing and jogging, playing tennis.

My favourite authors are Solzhenitsyn, Updike, Pelevin, Dostoyevsky, Vonnegut.

[http://vspx27.stanford.edu/cgi-bin/main.py?qtype=userpage&username=CopperKettle I participate] in the Folding@home project.

My last.fm account is [http://www.last.fm/user/CopperKettle/ here].

My [http://commons.wikimedia.org/wiki/User:CopperKettle Wikimedia page].

P.S. Reelin' cookies: If you know a foreign language into which Reelin is not yet translated, start a stub - and I will give you a cookie.

Pages I've started (about 149 thus far)

In no particular order, but generally newest up:

Articles To Start

::- See [https://www.minervamedica.it/en/journals/neurosurgical-sciences/article.php?cod=R38Y2020N04A0313&html=1&htmlID=Y1B5bU1kNDc4dEVmd1ovS2ZSMVF3VWFydjYwdC8vejBUVjhsYk96RGJoSjZFQ3o2ZGdDd0Vmc2Y0UkM5b0dTNA%3D%3D this] Italian consensus document on low-grade gliomas.

::- European [https://www.sciencedirect.com/science/article/pii/S2772610X2400028X recommendations] on pediatric low-grade gliomas

::Changes in keratoconus; marker associated w/ arterial stiffness

::SYNGAP1 gene

::[https://link.springer.com/article/10.1186/s11689-018-9225-1 CC-BY review, 2018], PMID 29402231

::What's the role of L-arginine?

::[https://cmbl.biomedcentral.com/articles/10.1186/s11658-023-00423-2 Review] - CC-BY

::Rather high impact factor

::[https://www.medrxiv.org/content/10.1101/2024.01.31.24301497v1 Assoc w/neurodevelopmental disorder]

:: Translate to Russian

::"CblE type"

::used in phrases like HoloTC assay

::Also known as Non-ketotic hyperglycaemic seizures

::Or Hypomyelinating leukodystrophies - see a [https://www.nature.com/articles/s41582-020-00432-1 2020 review]

  • SLC30A9 - variations traced back allegedly to Denisovans; mental illness
  • ??DOCKopathies - DOCK9 is associated w/keratoconus 7
  • ?Dystroglycanopathies
  • ??Multicystic encephalomalacia - present in Russian as Мультикистозная энцефаломаляция
  • ??? Typhoid psychosis
  • ?? Chemiluminescent Microparticle Immunoassay (CMIA)
  • ?Kristy Red-Horse of the North American Vascular Biology Organization
  • ??Natural autoantibodies - O.o [https://pubmed.ncbi.nlm.nih.gov/36979694/ Could be low in some cases of autism]
  • ??Cystic Neutrophilic Granulomatous Mastitis
  • ??[https://www.omim.org/geneMap/13/253?start=-3&limit=10&highlight=253 13q32] - related genes? KC, SZ
  • LNPK gene - developmental disorder, seizures (2018)
  • ?Cooking fuel, to cover effects on development?

::PMID: 37419197 DOI: 10.1016/j.envres.2023.116528

::- related to Orphan gene?

::See Resolvin

::They include Mabry syndrome; their number is estimated at 19 or 21

::[https://www.theguardian.com/society/2023/may/12/call-for-psychosis-treatment-overhaul-after-evidence-of-autoimmune-trigger Article in The Guardian, 2023]

::Reviewed in PMID 28144933

::Amazing case in PMID 8683509 (misdiagnosed as psychiatric for 10 years, then cured)

::-- as a standalone from Ketogenic diet

::Or as part of Insulin autoimmune syndrome (exists)?

:: "In a group of healthy adults, those who practiced high-resistance IMST for 30 breaths a day for six weeks saw their systolic blood pressure—the first number in a reading—drop by 9 millimeters of mercury"

::Folate supplementation prevents cognitive decline [https://rupress.org/jem/article/218/11/e20210846/212651/Implication-of-folate-deficiency-in-CYP2U1-loss-of in mouse model] (curious)

::Signs of putative folate deficiency in patients (see OMIM)

:*and Coefficient of fat absorption (72 h fecal collection)

:Psychologist, author of books, Uni of Toronto

::In some: "psychiatric abnormalities, including depression, bipolar disorder, hallucinations, aggressive behavior, and suicide attempts" (see OMIM)

::Might be assoc w/depression

::(2021)(REVIEW)(CC-BY) [https://onlinelibrary.wiley.com/doi/full/10.1002/jha2.321 Iron, neuro-bioavailability and depression] in eJHaem (IF: 4)

::OMIM 617788

:: linked to autism

::[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194706/ CC-BY images]

::[https://pubmed.ncbi.nlm.nih.gov/35002604/ 2021 review on Shankopathies in autism]

::[https://pubmed.ncbi.nlm.nih.gov/36636587/ Corrected with folinic acid: case report 2022]

::"miR483-5p/Pgap2 pathway regulates anxiety"

:: [https://omim.org/entry/620114 OMIM 620144], gene: CACNAC1I

:: This gene is assoc with both SZ and OCD

:"common in early stage bvFTD, arising prior to cognitive and neuroanatomic changes" ([https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.069296 Christopher Morrow et al., 2022])

::SLC30A9 gene

::Ameliorated by lipoic acid, presumably

::"prednisolone should provide a more valid test of the HPA axis in depression" ([https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/prednisolone-suppression-test-in-depression-prospective-study-of-the-role-of-hpa-axis-dysfunction-in-treatment-resistance/A7BA9E15E5769FA473C118A3E62C0184 Juruena et al 2018])

::Discovered galanin

:: as a standalone

::As a separate page?

::mir-184, assoc w/keratoconus

::Assoc w/keratoconus

::In Glutathione defiency (transient, for instance, with acetaminophen)

::Detection of Riboflavin deficiency

:: redox/inflammation

::[https://link.springer.com/article/10.1007/s40261-021-01038-1 The list in this review]

::Into a separate article. Riboflavin as treatment

::FGF3 gene

::[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226361/ CC-BY Review 2020]

::Leukoencephalopathy with thalamus and brainstem involvement and high lactate

  • EARS2 gene, mitochondrial enzyme

::Defects found in 2 patients with CFD

:*combined oxidative phosphorylation deficiency, subtype 12

:*combined oxidative phosphorylation deficiency 12

::Blunted in schizophrenia, linked to arachidonic acid pathway

::Obesity, inflammation

::A form of Ohtahara syndrome?

::OMIM 614671

::OMIM 614688

::Huntingtin gene hypofunction

::Write more

::Autistic features

::rare but curious

::Could be assoc w/schizophrenia via rs72657988

::Assoc w/psych disorders in [https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2801117?guestAccessKey=f874710c-c810-4320-9777-821fdcd6190b&utm_source=twitter&utm_medium=social_jamapsyc&utm_term=8796094283&utm_campaign=article_alert&linkId=199508352in offsprings]

::any link to folate metabolism?

::Decreased in SZ, Bipolar

::Gene CHD8

:: [https://florey.edu.au/about/news-media/world-first-pre-clinical-model-uncovers-cause-of-brain-injury-after-heart-surgery putative: inflammation triggered in blood by the cardio-lung-bypass machine]

::Investigated in ALZ's Disease, Parkinson's

::TIAM1 gene

::Pregnenolone derivative; might be used in alcoholism

:: Lasosamide - [https://www.psychiatrist.com/pcc/effects/acute-psychosis-precipitated-by-lacosamide/ induced psychosis] case

:: [https://www.sciencedirect.com/science/article/pii/S2211124721002850 CRMP2 and betaine?] O_O

:: OMIM 617744

:: Gene - NRF2, related to keratoconus

::??CSF-venous fistula - [https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12367 source]

::2022 Review of numerous genes/causes: PMID 35328062 (CC-BY 4.0)

::Gene: TYROBP

::Putative neuroprotection in Parkinson's; counters inflammatory cytokine signaling

::OMIM 619575

::gene - TAOK1

::Prompted by a report on a psych forum of depression/halluc. of a guy on cyprofloxacine

::[https://pubmed.ncbi.nlm.nih.gov/32905605/ Example review (2020) in PubMed]

::Gene: WDR45

::On withdrawal of dopamine medication

::CC-BY [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616322/ 2022 review in Cureus]

::Gene: KDM6B, could be associated with CFD

::Mutations in CDC42 which affects dendritic spines

::Linked to Early-onset vitamin B6-dependent epilepsy (OMIM 617290)

::Is it worth reading? ([https://www.sciencedirect.com/science/article/abs/pii/S0028390822004579 example article])

:: convert to standalone?

::Muscarinic, for schizophrenia

::Includes malondialdehyde, elevated in keratoconus serum

::First to attempt DBS in Parkinson's

::Autism and other manifestations; one of the genes: CYFIP1

::Two OMIM numbers: 613444 and 611913

::Alpha-aminoadipic semialdehyde

::of the book "Plague Cycle"

::Possible target of methotrexate in psoriasis

::Mutations in CAMKIIα

:: Autism spectrum

:: and ODC1 disorder - distinct?

::see myoclonic astatic epilepsy, aka Doose syndrome

::the RAC3 gene

::ACAD9

::Gene: MRE11A

::protein that might be useful in diabetes

::For instance, in deficiency of the mitochondrial folate transporter

::NSAID-induced

::gene: ATP2B1

::Mutations in the gene might be associated with BH4 deficiency in refractory depression, per Lisa Pan et al., 2020

:: Variants found in patients with refractory depression and BH4 deficiency by Lisa Pan et al., PMID 32128872

:: The same snp rs79258645 as in Lisa Pan et al is associated w/keratoconus [https://etheses.whiterose.ac.uk/11959/1/Final%20Thesis-%20LAF%20-%20080216.pdf Layal Fadi Abi Farraj, 2015]

::Mutations in NR4A2

::Exists in German Wikipedia

::To distinguish Cushing's from Pseudo-Cushing's

::Deficient serine transport into the brain

:: Disfunction in cerebral folate deficiency

:: Reviews: [https://www.annualreviews.org/doi/full/10.1146/annurev-nutr-082018-124235 2019] with mention of CFD

::See, for instance, table 1 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958922/ here] or a similar table in [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773593/ this] CC-BY review (2021)

:: See Pyridoxine 5′-phosphate oxidase

::Possible use in depression: [https://pubmed.ncbi.nlm.nih.gov/34572141/ review]

  • ?Folate trap in folate metabolism
  • ?Oculomics - research of eye-based biomarkers of non-ophthalmological pathology

::[https://doi.org/10.1093/schbul/sbac050 Schizophrenia in Translation: Why the Eye?]

:: Mutations in TUBB4A

:: Might be associated with cerebral folate deficiency

: accompanied by cerebral folate deficiency? Folinic acid helps, per PMID 31340680 (review)

:: " is the second most common of the known inherited disorders of folate metabolism" [https://onlinelibrary.wiley.com/doi/abs/10.1002/jimd.12035 18 cases]

:*davunetide, NAPVSIPQ

:*Navajo neurohepatopathy (NNH; 256810)

:extremely strange Luft's disease

:*[http://www.gastro.org.mx/docs/7163e.pdf review] at World J Gasto

:*[http://www.indianjgastro.com/IJG_pdf/jan2009/5-16.pdf Indian review] (2009), incl. pathogenesis

:*[http://www.jcircadianrhythms.com/content/7/1/6 Melatonin and sleep inversion]

:*..and atrichoblasts

:*:ru:Синдром хрупкой роговицы

:*ZNF469 gene

:*

The disorder has received several names, including acute diffuse lymphocytic meningoencephalitis,2,3 acute reversible limbic encephalitis,4 acute juvenile female nonherpetic encephalitis,1 or juvenile acute nonherpetic encephalitis.

::(see Felix Jacob Marchand)

::see {{PMID|11739428}} (high-prev. in CAH)

::see a [http://www.hindawi.com/journals/ijpe/2009/624823.html review] of rests in CAH

::(Cochet-Bonnet aesthesiometer )

Articles to expand and improve

  • Secondary predicate
  • Rickets - if "Magnesium-dependent vitamin-D-resistant rickets" is a real thing, add a mention.
  • Antiphospholipid syndrome - add info on psychiatric presentations (antibodies to annexins? Annexins are linked to p11, which is implicated in depression)

Articles to improve:

  • ATP6V0C - mention neurodevelopmental disorder with or without febrile seizures
  • SLC7A5 - amino acid brain transporter; autism spectrum disorder (see the Talk page)
  • Multiple acyl-CoA dehydrogenase deficiency - add mention of late onset cases [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606537/ (paper)]
  • GRIN1 subunit of the NMDAr: mutations -> developmental delay, seizures, ataxia (three OMIM entities)
  • UBE3B - mutations cause a developmental disorder and affect BCKDK, which also causes a developmental disorder
  • TMLHE - associated with autism, although with a low penetrance?
  • https://pubmed.ncbi.nlm.nih.gov/25943046/ - "The patient's neurodevelopmental deficits responded favorably to oral carnitine supplementation"
  • [https://pubmed.ncbi.nlm.nih.gov/28703319/ Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis]
  • PDXK mutations cause polyneuropathy responsive to PLP supplementation. Movement restored in patients.
  • Hyperprolinemia type II - behavioral problems, hallucinations [https://onlinelibrary.wiley.com/doi/full/10.1002/jimd.12060 (review)]
  • PCDH19 - is cerebral folate deficiency a typical feature of PCDH19-related epilepsy? Mention, if so.
  • Pay attention to the SZ-associated genes [https://www.medrxiv.org/content/10.1101/2020.09.18.20192815v1 discovered in this study]
  • Are POLG mutations associated with cerebral folate deficiency? Mention, if so.
  • Visceroptosis - add images from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773269/ here]
  • Cerebral small vessel disease (CSVD)
  • Methylenetetrahydrofolate reductase deficiency - add information on the severe (though rare) forms of the disease (review in PMID 26872964 (2016)). Such forms can manifest as psychosis and mental degradation accompanied by seizures. Very interesting.
  • MODY 2 - very interesting
  • Folate deficiency - add section on cerebral folate deficiency assoc. with catatonia and other psych symptoms
  • Hereditary folate malabsorption - read, investigate
  • Paraganglioma - add mention of "cluster 1" and "cluster 2" (genetics-based classification)
  • Cushing's syndrome - add description of the cyclic\intermittent Cushing's syndrome [http://www.eje-online.org/content/157/3/245.full review here 2007]
  • Cell bank
  • Microcarrier - used for growing cells in bioreactors;
  • Dilution cloning
  • Microextrusion
  • Corticogenesis
  • Zinin reaction
  • Thiocyanatoiron - hydrated form

Would be great to translate:

  • Into Russian:

:Endocrinology:

:*Stress hyperglycemia

:*Insulin autoimmune syndrome - Синдром аутоиммунитета к инсулину

:*GLUT1 deficiency - :ru:??

:Ukrainian music:

:*Sasha Boole

:*Victor Morozov

:*Zwyntar

:Psychiatry etc.:

:*Steven D. Hollon - "[https://www.sciencedirect.com/science/article/pii/S0005796724001268 rumination is good]"

:*Robert K. Naviaux >RU (mitochondrial function in mental disease)

:*Rumination (psychology), also known as Repetitive negative thinking

:*GMPPB depression, miopathy, D-mannose metabolism

:*Abdominal epilepsy curious

:*Acetylcysteinamide - a form of NAC

:*John Read (psychologist) - critic of psychiatry

:*Soluble guanylyl cyclase - target for a MELAS drug candidate

:*Autosomal dominant partial epilepsy with auditory features - but is it really linked to RELN?

:*Vertiginous epilepsy

:*Reflex seizure - for instance, while brushing teeth

:*Reading epilepsy (and improve)

:*High-frequency oscillations in epilepsy may offect cognition even in a non-seizure state

:*Corticotropin-releasing hormone antagonist

::For depression/anxiety

:*P11 for its role in depression.

:*PON1 together with MTHFR affects 5-MTHF metabolism, may be protective in schizophrenia by increasing CSF 5-MTHF

::Authors:

::*Richard Cotton (geneticist)

:::Studied DHPR defiency in 1975-2000 ([https://onlinelibrary.wiley.com/doi/10.1002/humu.22980 2016 review])

::*Bessel van der Kolk (PTSD)

::*Judith Lewis Herman (PTSD)

::*Lisa Bortolotti (delusions)

:*Levodopa-induced Dyskinesia

::Nitric oxide a culprit (NO also [https://doi.org/10.1002/advs.202205783 involved in autism]?)

:*?Sluggish cognitive tempo - does it exist?

:*Psychogenic polydipsia

:*Central diabetes insipidus

::May be [https://doi.org/10.1016/S2213-8587(23)00120-1 compounded] by oxitocin deficiency, causing anxiety

:Also improve: add info on falsely elevated free urine 24h cortisol

:*Glucocorticoid resistance - OMIM 615962

:*Overgeneral autobiographical memory

::[https://www.sciencedirect.com/science/article/pii/S0149763423001264 Curious 2023 meta-analysis]

::GABA breakdown inhibitor

::Assoc with keratoconus

::Metabolism changed in depression, other disorders

Articles I've contributed to

Acceptability of sources in medical articles

Questionable sources

Useful pages, FAQs

= Tools for protein infobox =

First get HGNCID [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2661 here], next populate using this tool [https://tools.wmflabs.org/citation-template-filling/cgi-bin/index.cgi?ddb=&type=pubmed_id&id=&add_param_space=1&add_ref_tag=1&full_journal_title=1 here].

== :commons:User:CopperKettle ==

I assert to be the same user as :commons:User:CopperKettle --CopperKettle 14:03, 22 February 2007 (UTC)

Les [[Encyclopédistes]]

  • {{userlinks|Sherurcij}} - a thoughful self-description
  • {{userlinks|Tjo3ya}} Timothy Osborne, a grammarian ([http://linguistics.stackexchange.com/users/2247/tim-osborne Stack Exchange])
  • {{userlinks|Libi Rubinsky}} - my sister ([http://hi.wikipedia.org/wiki/विशेष:योगदान/Libi_Rubinsky hi])
  • {{userlinks|TimVickers}} (director of MolCelBio project)
  • {{userlinks|Lilac_Soul}} (psychiatry, 1978, Netherlands)
  • {{userlinks|Joachimherz}} - [http://www8.utsouthwestern.edu/UTSW/FacDir/CDA/FindAFaculty/Results/FacDir_FacSearchRes/0,2357,13165,00.html Joachim Herz], neuroscience, Reelin, lipid signaling
  • {{userlinks|Psychiatrick}} (human rights, particularly in psychiatry)
  • {{userlinks|LittleHow}} - good-quality articles on neuropsychology
  • User:Boghog2
  • {{userlinks|Jmh649}}, a Canadian Doc.
  • User:EverSince
  • User:Shoemaker's Holiday
  • User:Fnielsen
  • User:Fuzzform (neuroscience)
  • User:Rvfrolov (neuroscience, cell biology)
  • User:TimVickers (enzymology, PhD; an admin)
  • User:Scientizzle (cell biology, medicine, pharmacology; an admin)
  • User:Shelbypark (history of psychiatry, asylums in Australia)
  • User:Garrondo (psychologist from Spain; FA: Alz)
  • {{userlinks|Xasodfuih}} (neuroscience\hormones?)
  • {{userlinks|Madhero88}} (Jordan; medical student; mad&heroic)
  • {{userlinks|Ekabhishek}} (India)
  • {{userlinks|Sphilbrick}} (Connecticut, Bayesian methods)
  • {{userlinks|Rajakhr}}, critical of psychiatry
  • {{userlinks|Rjanag}}, Chinese (?), psychology

Interesting stuff

Music to check out

Interesting folk

Subpages

ru:User:CopperKettle

fr:User:CopperKettle

Category:user ru-N

es:Usuario:CopperKettle

uk:Користувач:CopperKettle

ar:مستخدم:CopperKettle

nl:Gebruiker:CopperKettle

hi:User:CopperKettle

Category:Wikipedians interested in diabetes