GPR6
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.{{cite web | title = Entrez Gene: GPR6 G protein-coupled receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830}}{{cite journal | vauthors = Song ZH, Modi W, Bonner TI | title = Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors | journal = Genomics | volume = 28 | issue = 2 | pages = 347–349 | date = July 1995 | pmid = 8530049 | doi = 10.1006/geno.1995.1154 | url = https://zenodo.org/record/1229665 }}
Function
GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.{{cite journal | vauthors = Uhlenbrock K, Gassenhuber H, Kostenis E | title = Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors | journal = Cellular Signalling | volume = 14 | issue = 11 | pages = 941–953 | date = November 2002 | pmid = 12220620 | doi = 10.1016/S0898-6568(02)00041-4 }}
GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.{{cite journal | vauthors = Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y | title = Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth | journal = The Journal of Biological Chemistry | volume = 282 | issue = 14 | pages = 10506–10515 | date = April 2007 | pmid = 17284443 | doi = 10.1074/jbc.M700911200 | doi-access = free }}
Ligand
= Inverse Agonist =
- Cannabidiol{{cite journal | vauthors = Laun AS, Shrader SH, Brown KJ, Song ZH | title = GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol | journal = Acta Pharmacologica Sinica | volume = 40 | issue = 3 | pages = 300–308 | date = March 2019 | pmid = 29941868 | pmc = 6460361 | doi = 10.1038/s41401-018-0031-9 }}
- Solangepras (solengepras; CVN-424)
Evolution
= [[Sequence homology|Paralogues]] to GPR6 [[gene]] =
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, Marchese A, Tsui LC, Shi X, George SR | display-authors = 6 | title = Isolation of three novel human genes encoding G protein-coupled receptors | journal = DNA and Cell Biology | volume = 14 | issue = 1 | pages = 25–35 | date = January 1995 | pmid = 7832990 | doi = 10.1089/dna.1995.14.25 }}
- {{cite journal | vauthors = Song ZH, Modi W, Bonner TI | title = Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors | journal = Genomics | volume = 28 | issue = 2 | pages = 347–349 | date = July 1995 | pmid = 8530049 | doi = 10.1006/geno.1995.1154 | url = https://zenodo.org/record/1229665 }}
- {{cite journal | vauthors = Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E | title = Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells | journal = Cellular Physiology and Biochemistry | volume = 13 | issue = 2 | pages = 75–84 | year = 2003 | pmid = 12649592 | doi = 10.1159/000070251 | s2cid = 45156405 }}
{{refend}}
External links
- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3091 | title = GPR6 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2009-04-24 | archive-date = 2012-09-02 | archive-url = https://web.archive.org/web/20120902024823/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3091 | url-status = dead }}
{{G protein-coupled receptors}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}