LPAR2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.{{cite web | title = Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9170}}{{cite journal |vauthors=An S, Bleu T, Hallmark OG, Goetzl EJ | title = Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid | journal = J. Biol. Chem. | volume = 273 | issue = 14 | pages = 7906–10 | date=April 1998| pmid = 9525886 | doi = 10.1074/jbc.273.14.7906| doi-access = free }}{{cite journal |vauthors=An S, Bleu T, Zheng Y, Goetzl EJ | title = Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization | journal = Mol. Pharmacol. | volume = 54 | issue = 5 | pages = 881–8 | date=November 1998| pmid = 9804623 | doi = 10.1124/mol.54.5.881| s2cid = 37327084 }} LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J | date=January 2010| title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | pmid=20055701}}

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

Interactions

LPAR2 has been shown to interact with TRIP6.{{cite journal |last=Xu |first=Jun |author2=Lai Yun-Ju |author3=Lin Weei-Chin |author4=Lin Fang-Tsyr |date=March 2004|title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor |journal=J. Biol. Chem. |volume=279 |issue=11 |pages=10459–68 |location = United States| issn = 0021-9258| pmid = 14688263 |doi = 10.1074/jbc.M311891200 |pmc=3904432|doi-access=free }}

Evolution

= [[Sequence homology|Paralogues]] =

Source:{{Cite web |title=GeneCards®: The Human Gene Database |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR2&keywords=LPAR2#paralogs}}{{Cite web |title=Ensembl Genome Browser |url=https://useast.ensembl.org/Homo_sapiens/Gene/Compara_Paralog?db=core;g=ENSG00000064547;r=19:19623655-19628930}}

References

{{cite journal | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= 1|pages= 54–60 |year= 2000 |pmid= 10818441 |doi=10.1111/j.1749-6632.2000.tb06537.x |bibcode=2000NYASA.905...54S |s2cid=9257870 }}
{{cite journal |vauthors=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi= 10.1124/mol.58.6.1188|s2cid=6936621 }}
{{cite journal |vauthors=Goetzl EJ, Dolezalova H, Kong Y, etal |title=Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5370–5 |year= 1999 |pmid= 10537322 }}
{{cite journal |vauthors=Contos JJ, Chun J |title=Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. |journal=Genomics |volume=64 |issue= 2 |pages= 155–69 |year= 2000 |pmid= 10729222 |doi= 10.1006/geno.2000.6122 }}
{{cite journal |vauthors=Bandoh K, Aoki J, Taira A, etal |title=Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. |journal=FEBS Lett. |volume=478 |issue= 1–2 |pages= 159–65 |year= 2000 |pmid= 10922489 |doi=10.1016/S0014-5793(00)01827-5 |s2cid=21584151 |doi-access=free }}
{{cite journal |vauthors=Young KW, Bootman MD, Channing DR, etal |title=Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38532–9 |year= 2001 |pmid= 10954727 |doi= 10.1074/jbc.M006631200 |doi-access= free}}
{{cite journal |vauthors=Zheng Y, Voice JK, Kong Y, Goetzl EJ |title=Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. |journal=FASEB J. |volume=14 |issue= 15 |pages= 2387–9 |year= 2001 |pmid= 11024010 |doi= 10.1096/fj.00-0492fje |doi-access=free |s2cid=24778289 }}
{{cite journal |vauthors=Hama K, Bandoh K, Kakehi Y, etal |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1–3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=10.1016/S0014-5793(02)02976-9 |s2cid=44924895 |doi-access=free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Fujita T, Miyamoto S, Onoyama I, etal |title=Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. |journal=Cancer Lett. |volume=192 |issue= 2 |pages= 161–9 |year= 2003 |pmid= 12668280 |doi=10.1016/S0304-3835(02)00713-9 }}
{{cite journal |vauthors=Hu YL, Albanese C, Pestell RG, Jaffe RB |title=Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. |journal=J. Natl. Cancer Inst. |volume=95 |issue= 10 |pages= 733–40 |year= 2003 |pmid= 12759391 |doi=10.1093/jnci/95.10.733 |doi-access=free }}
{{cite journal |vauthors=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200 |pmc=3904432 |doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access=free }}
{{cite journal |vauthors=Oh YS, Jo NW, Choi JW, etal |title=NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 5069–79 |year= 2004 |pmid= 15143197 | pmc=416407 |doi= 10.1128/MCB.24.11.5069-5079.2004 }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 | pmc=528928 |doi= 10.1101/gr.2596504 }}

External links

{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991 | title = Lysophospholipid Receptors: LPA₂ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-05 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303171034/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991 | url-status = dead }}
{{MeshName|Lysophospholipid+receptors}}

Category:G protein-coupled receptors