S1PR5

{{Short description|Protein-coding gene in the species Homo sapiens}}

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₅.{{cite web | title = Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53637}}

Agonists

A-971432{{cite journal | vauthors = Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK | title = Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders | journal = Journal of Medicinal Chemistry | date = Nov 2015 | pmid = 26509640 | doi = 10.1021/acs.jmedchem.5b00928 | volume=58 | issue = 23 | pages=9154–70}}
Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012){{cite journal | vauthors = Roberts E, Guerrero M, Urbano M, Rosen H | title = Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012) | journal = Expert Opin Ther Pat | date = Jul 2013 | pmid = 23541049 | doi=10.1517/13543776.2013.783022 | volume=23 | issue = 7 | pages=817–41| s2cid = 24421259 }}

Evolution

= [[Sequence homology|Paralogues]] for S1PR5 Gene <ref>{{Cite web |title=GeneCards®: The Human Gene Database |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=S1PR5&keywords=s1pr5#paralogs}}</ref> =

References

{{cite journal | vauthors = Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR | title = Characterization of a novel sphingosine 1-phosphate receptor, Edg-8 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14281–6 | date = May 2000 | pmid = 10799507 | doi = 10.1074/jbc.275.19.14281 | doi-access = free }}
{{cite journal | vauthors = Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH | title = Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors | journal = The Journal of Biological Chemistry | volume = 276 | issue = 8 | pages = 5692–9 | date = Feb 2001 | pmid = 11069896 | doi = 10.1074/jbc.M003964200 | doi-access = free }}
{{cite journal | vauthors = Hla T | title = Sphingosine 1-phosphate receptors | journal = Prostaglandins | volume = 64 | issue = 1–4 | pages = 135–142 | date = Apr 2001 | pmid = 11331101 | doi = 10.1016/s0090-6980(01)00109-5 }}
{{cite journal | vauthors = Im DS, Clemens J, Macdonald TL, Lynch KR | title = Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors | journal = Biochemistry | volume = 40 | issue = 46 | pages = 14053–60 | date = Nov 2001 | pmid = 11705398 | doi = 10.1021/bi011606i }}
{{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1–3 | pages = 97–101 | date = Jun 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 | s2cid = 7116392 | doi-access = free }}
{{cite journal | vauthors = Niedernberg A, Scherer CR, Busch AE, Kostenis E | title = Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists | journal = Biochemical Pharmacology | volume = 64 | issue = 8 | pages = 1243–50 | date = Oct 2002 | pmid = 12234605 | doi = 10.1016/S0006-2952(02)01289-3 }}
{{cite journal | vauthors = Kothapalli R, Kusmartseva I, Loughran TP | title = Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1579 | issue = 2–3 | pages = 117–23 | date = Dec 2002 | pmid = 12427546 | doi = 10.1016/S0167-4781(02)00529-8 }}
{{cite journal | vauthors = Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B | title = Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 4 | pages = 693–700 | date = Apr 2003 | pmid = 12648236 | doi = 10.1046/j.1523-1747.2003.12096.x | doi-access = free }}
{{cite journal | vauthors = Ulfig N, Briese M | title = Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers | journal = Acta Histochemica | volume = 106 | issue = 5 | pages = 373–8 | year = 2005 | pmid = 15530552 | doi = 10.1016/j.acthis.2004.08.002 }}
{{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
{{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 | doi-access = free }}
{{cite journal | vauthors = Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H | title = The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease | journal = Alzheimer's & Dementia | date = Jun 2014 | doi = 10.1016/j.jalz.2014.07.153 | volume=10 | pages=P281| s2cid = 54386805 }}
{{cite journal | vauthors = Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J | title = T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow | journal = J Exp Med | date = Oct 2009 | pmid = 19808259 | doi=10.1084/jem.20090525 | volume=206 | issue = 11 | pmc=2768857 | pages=2469–81}}

External links

{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2997 | title = Lysophospholipid Receptors: S₁P₅ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
{{MeshName|Lysophospholipid+receptors}}

Category:G protein-coupled receptors