LPAR3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein in humans that is encoded by the LPAR3 gene.{{cite journal |vauthors=Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K | title = Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid | journal = J. Biol. Chem. | volume = 274 | issue = 39 | pages = 27776–85 |date=September 1999 | pmid = 10488122 | doi = 10.1074/jbc.274.39.27776 | doi-access = free }} LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J |date=January 2010 | title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | pmid=20055701}}

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.{{cite web | title = Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23566}}

Evolution

= [[Sequence homology|Paralogues]] =

Source:{{Cite web |title=GeneCards®: The Human Gene Database |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR3&keywords=LPAR3#paralogs}}

References

{{cite journal |vauthors=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi= 10.1124/mol.58.6.1188|s2cid=6936621 }}
{{cite journal |vauthors=Im DS, Heise CE, Harding MA, etal |title=Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. |journal=Mol. Pharmacol. |volume=57 |issue= 4 |pages= 753–9 |year= 2000 |pmid= 10727522 |doi= 10.1124/mol.57.4.753}}
{{cite journal |vauthors=Fitzgerald LR, Dytko GM, Sarau HM, etal |title=Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 3 |pages= 805–10 |year= 2000 |pmid= 10891327 |doi= 10.1006/bbrc.2000.2943 }}
{{cite journal |vauthors=Tokumura A, Sinomiya J, Kishimoto S, etal |title=Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 617–28 |year= 2002 |pmid= 11982483 | pmc=1222725 |doi= 10.1042/BJ20020348 }}
{{cite journal |vauthors=Hama K, Bandoh K, Kakehi Y, etal |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1–3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=10.1016/S0014-5793(02)02976-9 |s2cid=44924895 |doi-access=free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Cremers B, Flesch M, Kostenis E, etal |title=Modulation of myocardial contractility by lysophosphatidic acid (LPA). |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 1 |pages= 71–80 |year= 2003 |pmid= 12623301 |doi=10.1016/S0022-2828(02)00279-1 }}
{{cite journal |vauthors=Fujita T, Miyamoto S, Onoyama I, etal |title=Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. |journal=Cancer Lett. |volume=192 |issue= 2 |pages= 161–9 |year= 2003 |pmid= 12668280 |doi=10.1016/S0304-3835(02)00713-9 }}
{{cite journal |vauthors=Jin Y, Knudsen E, Wang L, Maghazachi AA |title=Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization. |journal=Eur. J. Immunol. |volume=33 |issue= 8 |pages= 2083–9 |year= 2003 |pmid= 12884281 |doi= 10.1002/eji.200323711 |s2cid=41960806 |doi-access=free }}
{{cite journal |vauthors=Xing Y, Ganji SH, Noh JW, Kamanna VS |title=Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth. |journal=Am. J. Physiol. Renal Physiol. |volume=287 |issue= 6 |pages= F1250–7 |year= 2005 |pmid= 15292052 |doi= 10.1152/ajprenal.00342.2003 }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 | pmc=528928 |doi= 10.1101/gr.2596504 }}

External links

{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2992 | title = Lysophospholipid Receptors: LPA₃ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-05 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303193938/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2992 | url-status = dead }}

Category:G protein-coupled receptors