Melanocortin 5 receptor

MC₅R is necessary for normal sebum production.{{cite journal | vauthors = Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD | title = Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides | journal = Cell | volume = 91 | issue = 6 | pages = 789–98 | date = December 1997 | pmid = 9413988 | doi = 10.1016/S0092-8674(00)80467-5 | s2cid = 6251691 | doi-access = free }}{{cite journal | vauthors = Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M | title = Melanocortin-5 receptor and sebogenesis. | journal = Eur J Pharmacol | volume = 660 | issue = 1 | pages = 202–206 | date = June 2011 | pmid = 21215742 | doi = 10.1016/j.ejphar.2010.10.100 }} Stimulation of MC₅R promotes fatty acid oxidation in skeletal muscle{{cite journal | vauthors = An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK | title = Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle | journal = The Journal of Biological Chemistry | volume = 282 | issue = 5 | pages = 2862–70 | date = February 2007 | pmid = 17127674 | doi = 10.1074/jbc.M603454200 | doi-access = free }} and lypolysis in adipocytes.{{cite journal | vauthors = Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS | title = Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. | journal = Mol Cell Endocrinol | volume = 341 | issue = 1–2 | pages = 9–17 | date = July 2011 | pmid = 21616121 | doi = 10.1016/j.mce.2011.03.010 | s2cid = 31837693 | url = https://hal.archives-ouvertes.fr/hal-00719880/file/PEER_stage2_10.1016%252Fj.mce.2011.03.010.pdf }} MC₅R is essential for erythrocyte differentiation.{{cite journal | vauthors = Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T | title = Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. | journal = PLOS ONE | volume = 10 | issue = 4 | pages = e0123232 | date = April 2015 | pmid = 25860801 | doi = 10.1371/journal.pone.0123232 | pmc=4393082| bibcode = 2015PLoSO..1023232S | doi-access = free }} MC₅R is involved in inflammation.{{cite journal | vauthors = Lee DJ, Taylor AW | title = Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. | journal = J. Immunol. | volume = 191| issue = 8 | pages = 4103–4111 | date = October 2013 | pmid = 24043903 | doi = 10.4049/jimmunol.1300182 | pmc=3796047}}{{cite journal | vauthors = Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT | title = Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes. | journal = J Mol Endocrinol | volume = 44 | issue = 4 | pages = 225–236 | date = April 2010 | pmid = 20089716 | doi = 10.1677/JME-09-0161 | pmc=3058511}} MC₅R helps maintain thermal homeostasis.{{cite journal | vauthors = Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML | title = Biphasic effect of melanocortin agonists on metabolic rate and body temperature. | journal = Cell Metab. | volume = 20 | issue = 2 | pages = 333–345 | date = August 2014 | pmid = 24981835 | doi = 10.1016/j.cmet.2014.05.021 | pmc=4126889}}

MC₅R is expressed in the brain at different levels depending on physical activity.{{cite journal | vauthors = Shukla C, Britton SL, Koch LG, Novak CM | title = Region-specific differences in brain melanocortin receptors in rats of the lean phenotype. | journal = NeuroReport | volume = 23 | issue = 10 | pages = 596–600 | date = July 2012 | pmid = 22643233 | doi = 10.1097/WNR.0b013e328354f5c1 | pmc=3831884}}

MC₅R is heavily expressed in the preputial gland in mice (a modified sebaceous gland involved in pheromone production). MC₅R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC₅R-deficient males through pheromonal signals.{{cite journal | vauthors = Morgan C, Thomas RE, Cone RD | title = Melanocortin-5 receptor deficiency promotes defensive behavior in male mice. | journal = Horm. Behav. | volume = 45 | issue = 1 | pages = 56–63 | date = January 2004 | pmid = 14733892 | doi = 10.1016/j.yhbeh.2003.08.004 | s2cid = 32531156 }}{{cite journal | vauthors = Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD | title = Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice. | journal = Chem Senses | volume = 29 | issue = 2 | pages = 111–115 | date = February 2004 | pmid = 14977807 | doi=10.1093/chemse/bjh011| doi-access = free }}{{cite journal | vauthors = Morgan C, Cone RD | title = Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression. | journal = Behav. Genet. | volume = 36 | issue = 2 | pages = 291–300 | date = January 2006 | pmid = 16408249 | doi=10.1007/s10519-005-9024-9| s2cid = 9659300 }}

Melanocortin 2 receptor accessory protein (MRAP) traps MC₅R protein inside cells.{{cite journal | vauthors = Sebag JA, Hinkle PM | title = Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. | journal = J Biol Chem | volume = 284 | issue = 34 | pages = 22641–22648 | date = August 2009 | pmid = 19535343 | doi = 10.1074/jbc.M109.022400 | pmc=2755671| doi-access = free }}

Source:{{Cite web |title=GeneCards®: The Human Gene Database |url=https://genecards.org/cgi-bin/carddisp.pl?gene=MC5R&keywords=mc5r#paralogs}}

• MC4R
• MC3R
• MC1R
• MC2R
• S1PR1
• LPAR1
• S1PR3
• GPR12
• LPAR2
• GPR3
• S1PR2
• GPR6
• GPR119
• LPAR3
• CNR1
• S1PR5
• S1PR4
• CNR2

• Melanocortin receptor

{{reflist|33em}}

{{refbegin|33em}}

• {{cite journal | vauthors = Fathi Z, Iben LG, Parker EM | title = Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype | journal = Neurochemical Research | volume = 20 | issue = 1 | pages = 107–13 | date = January 1995 | pmid = 7739752 | doi = 10.1007/BF00995160 | s2cid = 20792213 }}
• {{cite journal | vauthors = Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V | title = Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 68 | issue = 1–2 | pages = 79–81 | year = 1994 | pmid = 7956366 | doi = 10.1159/000133895 }}
• {{cite journal | vauthors = Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P | title = Molecular cloning and characterization of the rat fifth melanocortin receptor | journal = Biochemical and Biophysical Research Communications | volume = 200 | issue = 2 | pages = 1007–14 | date = April 1994 | pmid = 8179577 | doi = 10.1006/bbrc.1994.1550 }}
• {{cite journal | vauthors = Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T | title = Molecular cloning, expression, and characterization of a fifth melanocortin receptor | journal = Biochemical and Biophysical Research Communications | volume = 200 | issue = 3 | pages = 1214–20 | date = May 1994 | pmid = 8185570 | doi = 10.1006/bbrc.1994.1580 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/31580/1/0000508.pdf | hdl = 2027.42/31580 | hdl-access = free }}
• {{cite journal | vauthors = Chhajlani V | title = Distribution of cDNA for melanocortin receptor subtypes in human tissues | journal = Biochemistry and Molecular Biology International | volume = 38 | issue = 1 | pages = 73–80 | date = February 1996 | pmid = 8932521 }}
• {{cite journal | vauthors = Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I | title = Effects of recombinant agouti-signaling protein on melanocortin action | journal = Molecular Endocrinology | volume = 11 | issue = 3 | pages = 274–80 | date = March 1997 | pmid = 9058374 | doi = 10.1210/mend.11.3.9898 | doi-access = free }}
• {{cite journal | vauthors = Frändberg PA, Xu X, Chhajlani V | title = Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 2 | pages = 489–92 | date = July 1997 | pmid = 9240466 | doi = 10.1006/bbrc.1997.6994 }}
• {{cite journal | vauthors = Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I | title = Characterization of Agouti-related protein binding to melanocortin receptors | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 148–55 | date = January 1999 | pmid = 9892020 | doi = 10.1210/me.13.1.148 | doi-access = }}
• {{cite journal | vauthors = Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL | title = Expression, candidate gene, and population studies of the melanocortin 5 receptor | journal = The Journal of Investigative Dermatology | volume = 116 | issue = 4 | pages = 564–70 | date = April 2001 | pmid = 11286624 | doi = 10.1046/j.0022-202x.2001.01286.x | doi-access = free }}
• {{cite journal | vauthors = Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH | title = Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro | journal = Journal of Medicinal Chemistry | volume = 44 | issue = 22 | pages = 3665–72 | date = October 2001 | pmid = 11606131 | doi = 10.1021/jm010165y }}
• {{cite journal | vauthors = Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE | title = Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes | journal = Molecular Pharmacology | volume = 67 | issue = 1 | pages = 50–9 | date = January 2005 | pmid = 15470082 | doi = 10.1124/mol.104.002857 | s2cid = 13536417 }}
• {{cite journal | vauthors = Lohoff FW, Berrettini WH | title = Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder | journal = Psychiatric Genetics | volume = 15 | issue = 4 | pages = 255–8 | date = December 2005 | pmid = 16314755 | doi = 10.1097/00041444-200512000-00007 | s2cid = 21170090 }}
• {{cite journal | vauthors = Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ | title = Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5 | journal = Peptides | volume = 28 | issue = 6 | pages = 1191–6 | date = June 2007 | pmid = 17482720 | pmc = 1955225 | doi = 10.1016/j.peptides.2007.02.012 }}

{{refend}}

• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2356 | title = Melanocortin Receptors: MC₅ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-05 | archive-date = 2014-07-14 | archive-url = https://web.archive.org/web/20140714111153/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2356 | url-status = dead }}

{{NLM content}}

{{G protein-coupled receptors}}

{{Melanocortin receptor modulators}}

Category:G protein-coupled receptors

Category:Human proteins