List of capsaicinoids

|+

!Structural formula

!Name

!Scoville heat units

!Abbreviation

!Reference

|Resiniferatoxin

|16,000,000,000

|RTX

|{{Cite magazine | vauthors = Simon M |title=This Chemical Is So Hot It Destroys Nerve Fibers—in a Good Way |language=en-US |magazine=Wired |url=https://www.wired.com/story/resiniferatoxin/ |access-date=2023-08-25 |issn=1059-1028}}{{Cite web |title=Resiniferatoxin Is 1,000 Times Hotter Than Pure Hot Pepper Heat |url=https://www.thoughtco.com/hottest-chemical-resiniferatoxin-3975976 |access-date=2023-08-25 |website=ThoughtCo |language=en}}{{cite journal | vauthors = Premkumar LS | title = Transient receptor potential channels as targets for phytochemicals | journal = ACS Chemical Neuroscience | volume = 5 | issue = 11 | pages = 1117–1130 | date = November 2014 | pmid = 24926802 | pmc = 4240255 | doi = 10.1021/cn500094a }}

|Tinyatoxin

|5,300,000,000

|TTX or TTN

|

|Phenylacetylrinvanil

|4,800,000,000

|IDN-5890

|{{cite journal | vauthors = Appendino G, De Petrocellis L, Trevisani M, Minassi A, Daddario N, Moriello AS, Gazzieri D, Ligresti A, Campi B, Fontana G, Pinna C, Geppetti P, Di Marzo V | display-authors = 6 | title = Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 312 | issue = 2 | pages = 561–570 | date = February 2005 | pmid = 15356216 | doi = 10.1124/jpet.104.074864 | s2cid = 816699 }}{{cite journal | vauthors = Luviano A, Aguiñiga-Sánchez I, Demare P, Tiburcio R, Ledesma-Martínez E, Santiago-Osorio E, Regla I | title = Antineoplastic activity of rinvanil and phenylacetylrinvanil in leukaemia cell lines | journal = Oncology Letters | volume = 7 | issue = 5 | pages = 1651–1656 | date = May 2014 | pmid = 24765194 | pmc = 3997731 | doi = 10.3892/ol.2014.1958 }}{{cite journal | vauthors = Sánchez-Sánchez L, Alvarado-Sansininea JJ, Escobar ML, López-Muñoz H, Hernández-Vázquez JM, Monsalvo-Montiel I, Demare P, Regla I, Weiss-Steider B | display-authors = 6 | title = Evaluation of the antitumour activity of Rinvanil and Phenylacetylrinvanil on the cervical cancer tumour cell lines HeLa, CaSKi and ViBo | journal = European Journal of Pharmacology | volume = 758 | pages = 129–136 | date = July 2015 | pmid = 25864613 | doi = 10.1016/j.ejphar.2015.04.003 }}

|Capsaicin

|16,000,000

|CPS

|{{Cite web | vauthors = Hultquist M |date=2019-06-18 |title=The Scoville Scale |url=https://www.chilipeppermadness.com/frequently-asked-questions/the-scoville-scale/ |access-date=2023-08-25 |website=Chili Pepper Madness |language=en-US}}

|Dihydrocapsaicin

|16,000,000

|DHC

|{{Cite web |title=Dihydrocapsaicin - an overview {{!}} ScienceDirect Topics |url=https://www.sciencedirect.com/topics/neuroscience/dihydrocapsaicin |access-date=2023-08-25 |website=www.sciencedirect.com}}

|Nonivamide

|9,200,000

|PAVA

|{{cite journal | vauthors = Rohm B, Holik AK, Kretschy N, Somoza MM, Ley JP, Widder S, Krammer GE, Marko D, Somoza V | display-authors = 6 | title = Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells | journal = Journal of Cellular Biochemistry | volume = 116 | issue = 6 | pages = 1153–1163 | date = June 2015 | pmid = 25704235 | pmc = 4949678 | doi = 10.1002/jcb.25052 | publication-date = 2015-04-10 }}

|Nordihydrocapsaicin

|9,000,000

|NDHC

|

|Homocapsaicin

|8,600,000

|HC

|

|Homodihydrocapsaicin

|8,600,000

|HDHC

|

|Shogaol

|150,000

|6-SGL

|{{Cite journal | vauthors = Kemkar KI, Sathiyanarayanan L, Sathiyanarayanan AR, Mahadik KA |date=2018-01-01 |title= 6-Shogaol rich ginger oleoresin loaded mixed micelles enhances in vitro cytotoxicity on MCF-7 cells and in vivo anticancer activity against DAL cells. |journal=International Journal of Pharmacy and Pharmaceutical Sciences |volume=10 |language=en |pages=160–168 |doi=10.22159/ijpps.2018v10i1.23077 |issn=0975-1491|doi-access=free }}

|Piperine

|100,000

|PIP

|{{cite journal | vauthors = Azam S, Park JY, Kim IS, Choi DK | title = Piperine and Its Metabolite's Pharmacology in Neurodegenerative and Neurological Diseases | journal = Biomedicines | volume = 10 | issue = 1 | pages = 154 | date = January 2022 | pmid = 35052833 | pmc = 8773267 | doi = 10.3390/biomedicines10010154 | doi-access = free }}

|Gingerol

|80,000

|6-G

|{{cite journal | vauthors = Mazyed EA, Badria FA, ElNaggar MH, El-Masry SM, Helmy SA | title = Development of Cyclodextrin-Functionalized Transethoniosomes of 6-Gingerol: Statistical Optimization, In Vitro Characterization and Assessment of Cytotoxic and Anti-Inflammatory Effects | journal = Pharmaceutics | volume = 14 | issue = 6 | pages = 1170 | date = May 2022 | pmid = 35745746 | doi = 10.3390/pharmaceutics14061170 | pmc = 9227240 | doi-access = free }}

|Capsiate

|16,000

|CAP

|{{cite journal | vauthors = de Moura E, Silva VE, Cholewa JM, Jäger R, Zanchi NE, de Freitas MC, de Moura RC, Barros EM, Antunes BM, Caperuto EC, Ribeiro SL, Lira FS, Pereira Dos Santos MA, Rossi FE | display-authors = 6 | title = Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study | journal = Journal of the International Society of Sports Nutrition | volume = 18 | issue = 1 | pages = 50 | date = June 2021 | pmid = 34154603 | pmc = 8218493 | doi = 10.1186/s12970-021-00446-0 | doi-access = free }}{{Cite web | vauthors = Helmenstine A |date=2018-03-22 |title=Scoville Scale for Peppers and Other Hot Chemicals |url=https://sciencenotes.org/scoville-scale-peppers-hot-chemicals/ |access-date=2023-08-25 |website=Science Notes and Projects |language=en-US}}

|Norcapsaicin

|~0The SHU for Norcapsaicin and Nornorcapsaicin has not been measured. However, they are both present in bell peppers which have an SHU of 0 and so these compounds likely have an SHU of 0 or slightly above.

|(NA)

|{{cite journal | vauthors = Hamed M, Kalita D, Bartolo ME, Jayanty SS | title = Capsaicinoids, Polyphenols and Antioxidant Activities of Capsicum annuum: Comparative Study of the Effect of Ripening Stage and Cooking Methods | journal = Antioxidants | volume = 8 | issue = 9 | pages = 364 | date = September 2019 | pmid = 31480665 | pmc = 6770197 | doi = 10.3390/antiox8090364 | doi-access = free }}{{Cite web | work = PubChem |title=Norcapsaicin |url=https://pubchem.ncbi.nlm.nih.gov/compound/6442577 |access-date=2023-08-25 | publisher = U.S. National Library of Medicine |language=en}}{{Cite web |title=Human Metabolome Database: Showing metabocard for Norcapsaicin (HMDB0036327) |url=https://hmdb.ca/metabolites/HMDB0036327 |access-date=2023-08-25 |website=hmdb.ca}}

|Nornorcapsaicin

|~0

|(NA)

|{{Cite web |title=Human Metabolome Database: Showing metabocard for Dinorcapsaicin (HMDB0036325) |url=https://hmdb.ca/metabolites/HMDB0036325 |access-date=2023-08-25 |website=hmdb.ca}}{{Cite web | work = PubChem |title=Nornorcapsaicin |url=https://pubchem.ncbi.nlm.nih.gov/compound/6442578 |access-date=2023-08-25 | publisher = U.S. National Library of Medicine |language=en}}