| class="wikitable" style="text-align:center; border:1px #aaf solid;" |
| #
!Image
!Name
!width=120px|Position
!Tenure started
!Tenure ended
!President |
|---|
| 1
|135x135px
|Juan Nolasco
| rowspan="2" |Secretary of Public Instruction, Health and Welfare[{{Cite web |title=Executive Order No. 396, s. 1941 |url=https://www.officialgazette.gov.ph/1941/12/24/executive-order-no-396-s-1941/ |website=Official Gazette of the Republic of the Philippines}}]
|November 15,
1935
|December 24,
1941
| rowspan="2" |Manuel L. Quezon |
| 2{{Efn|In concurrent capacity as Vice President.}}
|142x142px
|Sergio Osmeña
(1878–1961)
[{{Cite book |title=The Sixth Annual Report of the United States High Commissioner to the Philippine Islands to the President and Congress of the United States Covering the Fiscal Year July 1, 1941 to June 30, 1942 |publisher=Government Printing Office |year=1943 |location=Washington |pages=79}}]
|December 24,
1941
|August 1,
1944 |
| 3
|131x131px
|Claro M. Recto
(1890–1960)
[{{Cite book |title=Official Gazette Vol. 1, No. 1 |publisher=Bureau of Printing |year=1942 |location=Manila |pages=15}}]
|Commissioner of Education, Health and Welfare
|January 26,
1942
|October 14,
1943
|Jorge B. Vargas{{Efn|As Chairman of the Philippine Executive Commission.}} |
| –{{Efn|Acting secretary.|name=actingsecretary}}
|
|Gabriel Mañalac
[{{Cite book |title=Official Gazette, Vol. 1, No. 2 |publisher=Bureau of Printing |year=1943 |location=Manila |pages=131}}]
|Minister of Education, Health and Public Welfare
|October 20,
1943
|January 1,
1944
| rowspan="2" |Jose P. Laurel |
| 4
|138x138px
|Emiliano Tría Tirona
(1883–1952)
[{{Cite book |title=Official Gazette, Vol. 1, No. 4 |publisher=Bureau of Printing |year=1944 |location=Manila |pages=391}}]
|Minister of Health, Labor and Public Welfare
|January 4,
1944
|1945 |
| 5
|130x130px
|Basilio Valdes
(1892–1970)
| rowspan="3" |Secretary of Health and Public Welfare[{{Cite web |title=Executive Order No. 27, s. 1945 |url=https://www.officialgazette.gov.ph/1945/02/27/executive-order-no-27-s-1945/ |website=Official Gazette of the Republic of the Philippines}}]
|February 27,
1945
|April
1945
| rowspan="2" |Sergio Osmeña |
| 6
|154x154px
|Jose Locsin
(1891–1977)
|June 29,
1945
|May 27,
1946 |
| rowspan="3" |7
| rowspan="3" |100px
| rowspan="3" |Antonio Villarama
|May 28,
1946
|October 4,
1947
| rowspan="2" |Manuel Roxas |
rowspan="13" |Secretary of Health[{{Cite web |title=Executive Order No. 94, s. 1947 |url=https://www.officialgazette.gov.ph/1947/10/04/executive-order-no-94-s-1947/ |website=Official Gazette of the Republic of the Philippines}}]
| rowspan="2" |October 4,
1947
| rowspan="2" |December 31,
1949 |
| rowspan="2" |Elpidio Quirino |
| style="height:70px;"
| rowspan="2" |8
| rowspan="2" |141x141px
| rowspan="2" |Juan Salcedo Jr.
(1904–1988)
| rowspan="2" |December 14,
1950
| rowspan="2" |May
1954 |
| rowspan="2" |Ramon Magsaysay |
| style="height:30px;"
| rowspan="2" |9
| rowspan="2" |100px
| rowspan="2" |Paulino Garcia
| rowspan="2" |June
1954
| rowspan="2" |June
1958 |
| rowspan="2" |Carlos P. Garcia |
| 10
|
|Elpidio Valencia
|July
1958
|December 30,
1961 |
| 11
|
|Francisco Duque Jr.
|December 30,
1961
|July
1963
| rowspan="3" |Diosdado Macapagal |
| 12
|
|Floro Dabu
|July
1963
|December
1964 |
| 13
|
|Manuel Cuenco
|December
1964
|December 30,
1965 |
| (9)
|100px
|Paulino Garcia
|December 30,
1965
|August 2,
1968
| rowspan="6" |Ferdinand Marcos |
| 14
|
|Amadeo Cruz
|August 2,
1968
|December 25,
1971 |
| rowspan="2" |15
| rowspan="2" |
| rowspan="2" |Clemente Gatmaitan
|December 25,
1971
|June 2,
1978 |
rowspan="4" |Minister of Health[{{Cite web |title=Presidential Decree No. 1397, s. 1978 |url=https://www.officialgazette.gov.ph/1978/06/02/presidential-decree-no-1397-s-1978/ |website=Official Gazette of the Republic of the Philippines}}]
|June 2,
1978
|July 23,
1979 |
| 16
|
|Enrique Garcia
|July 24,
1979
|June 30,
1981 |
| 17
|100px
|Jesus Azurin
|July 25,
1981
|February 25,
1986 |
| rowspan="2" |18
| rowspan="2" |
| rowspan="2" |Alfredo Bengzon
(born 1935)
|March 25,
1986
|February 11,
1987
| rowspan="3" |Corazon Aquino |
rowspan="18" |Secretary of Health[{{Cite web |title=Administrative Order No. 15, s. 1987 |url=https://www.officialgazette.gov.ph/1987/02/11/administrative-order-no-15-s-1987/ |website=Official Gazette of the Republic of the Philippines}}]
|February 11,
1987
|February 7,
1992 |
| 19
|
|Antonio Periquet
|February 10,
1992
|June 30,
1992 |
| 20
|135x135px
|Juan Flavier
(1935–2014)
|July 1,
1992
|January 30,
1995
| rowspan="4" |Fidel V. Ramos |
| 21
|
|Jaime Galvez-Tan
|January 30,
1995
|July 5,
1995 |
| 22
|
|Hilarion Ramiro Jr.
|July 10,
1995
|March 22,
1996 |
| 23
|
|Carmencita Reodica
|April 8,
1996
|June 29,
1998 |
| 24
|
|Felipe Estrella
|June 30,
1998
|September 13,
1998
| rowspan="2" |Joseph Estrada |
| 25
|
|Alberto Romualdez
(1940–2013)
|September 14,
1998
|January 20,
2001 |
| 26
|
|Manuel Dayrit
|January 20,
2001
|June 1,
2005
| rowspan="3" |Gloria Macapagal Arroyo |
| 27
|147x147px
|Francisco Duque III
(born 1957)
|June 1,
2005
|September 1,
2009 |
| 28
|145x145px
|Esperanza Cabral
|September 1,
2009
|June 30,
2010 |
| 29
|
|Enrique Ona
(born 1939)
[{{cite web |title=Benigno S. Aquino III |url=http://malacanang.gov.ph/presidents/fifth-republic/benigno-aquino-iii/ |archive-url=https://web.archive.org/web/20160706080719/http://malacanang.gov.ph/presidents/fifth-republic/benigno-aquino-iii/#efs-tabpane-1-1 |archive-date=July 6, 2016 |access-date=June 25, 2022 |website=Presidential Museum and Library}}]
|June 30,
2010
|December 19,
2014
| rowspan="2" |Benigno Aquino III |
| 30
|133x133px
|Janette Garin
(born 1972)
|February 17,
2015
|June 30,
2016 |
| –{{Efn|Interim secretary.}}
|131x131px
|Paulyn Ubial
(born 1962)
[{{cite news |last1=Viray |first1=Patricia Lourdes |date=June 30, 2016 |title=Duterte's Cabinet takes oath, holds first meeting |url=https://www.philstar.com/headlines/2016/06/30/1598175/dutertes-cabinet-takes-oath-holds-first-meeting |archive-url=https://web.archive.org/web/20160701152211/https://www.philstar.com/headlines/2016/06/30/1598175/dutertes-cabinet-takes-oath-holds-first-meeting |archive-date=July 1, 2016 |work=The Philippine Star}}][{{cite news |last1=Avendaño |first1=Christine O. |date=October 10, 2017 |title=Ubial out as DOH head as CA rejects 5th Duterte Cabinet appointee |url=https://newsinfo.inquirer.net/936871/news-paulyn-ubial-commission-on-appointments-cabinet-gregorio-honasan-department-of-health |archive-url=https://web.archive.org/web/20171010095427/https://newsinfo.inquirer.net/936871/news-paulyn-ubial-commission-on-appointments-cabinet-gregorio-honasan-department-of-health |archive-date=October 10, 2017 |newspaper=Philippine Daily Inquirer |language=en}}]
|June 30,
2016
|October 10,
2017
| rowspan="3" |Rodrigo Duterte |
| –{{Efn|Officer in charge.|name=oic}}
|
|Herminigildo Valle
[{{cite news |last1=Placido |first1=Dharel |date=October 12, 2017 |title=Duterte names OICs of health, information technology departments |url=http://news.abs-cbn.com/news/10/12/17/duterte-names-oics-of-health-information-technology-departments |archive-url=https://web.archive.org/web/20171027065411/http://news.abs-cbn.com/news/10/12/17/duterte-names-oics-of-health-information-technology-departments |archive-date=October 27, 2017 |work=ABS-CBN News}}]
|October 12,
2017
|October 25,
2017 |
| (27)
|147x147px
|Francisco Duque III
(born 1957)
[{{cite news |date=October 26, 2017 |title=Duterte appoints former DOH secretary to replace Ubial |url=https://www.cnnphilippines.com/news/2017/10/26/new-Department-of-Health-secretary-Francisco-Duque.html |url-status=dead |archive-url=https://web.archive.org/web/20171028213758/http://cnnphilippines.com/news/2017/10/26/new-Department-of-Health-secretary-Francisco-Duque.html |archive-date=October 28, 2017 |work=CNN Philippines}}]
|October 26,
2017
|June 30,
2022 |
| –{{Efn | name=oic}}
|122x122px
|Maria Rosario Vergeire
|July 14,
2022
|June 5,
2023
| rowspan="2" |Bongbong Marcos |
| 31
|128x128px
|Ted Herbosa
(born 1959)
|June 5,
2023
|Incumbent |
