1516

• January 20 – Juan Díaz de Solís arrives in what is now Punta del Este in Uruguay, where he becomes the first European to sail into the Río de la Plata (in future Argentina). Díaz and nine of his men are attacked and killed by the local Charrúa people shortly after their arrival.{{cite web|access-date=3 February 2016 |author=El País |date=3 February 2016 |title=Recrearon desembarco de Solís en playa Mansa, a los 500 años |url=http://www.elpais.com.uy/informacion/recrearon-desembarco-solis-playa-mansa.html}}{{cite book |last1=Grimshaw |first1=William |title=The History of South America, from the Discovery of the New World by Columbus, to the Conquest of Peru by Pizarro |date=1830 |publisher=Collins & Hannay |page=89 |url=https://books.google.com/books?id=TXMOAAAAYAAJ&dq=Juan+D%C3%ADaz+de+Sol%C3%ADs+Juan+D%C3%ADaz+de+Sol%C3%ADs+%22january+1516%22&pg=PA89 |access-date=16 July 2023 |language=en}} although there was likely an expedition earlier in 1511-1512 by João de Lisboa and Estevão de Fróis.{{cite book |last1=Johnson |first1=H. B. |title=Colonial Brazil |date=1987 |publisher=Cambridge University Press |isbn=978-0-521-34925-3 |pages=1–38 |chapter-url=https://www.cambridge.org/core/books/abs/colonial-brazil/portuguese-settlement-15001580/FC806C3693A5B6570D835FA828EDDA15 |access-date=16 July 2023 |chapter=Portuguese settlement, 1500–1580}}
• January 23 – With the death of Ferdinand II of Aragon, his grandson, Charles of Ghent, becomes King of Spain;{{cite book|author=Joseph F. O'Callaghan|title=A History of Medieval Spain|url=https://books.google.com/books?id=yA3p6v3UxyIC&pg=PA675|date=31 August 1983|publisher=Cornell University Press|isbn=0-8014-9264-5|pages=675}} his mother Queen Joanna of Castile also succeeds as Queen of Aragon and co-monarch with Carlos, but remains confined at Tordesillas.
• February 18 – After two months in Bologna, part of the Papal States in Italy, Pope Leo X concludes two months of negotiation with King François I of France. Their talks result in the abrogation of the French Pragmatic Sanction, and the conclusion of a new Concordat between the Papacy and France.{{cite book|author=Gaetano Moroni|title=Dizionario di erudizione storico-ecclesiastica da S. Pietro sino ai nostri giorni ...|url=https://books.google.com/books?id=ALtDAAAAIAAJ|year=1840|publisher=Tipografia Emiliana|language=it|pages=299–300}} Jules Thomas, [https://archive.org/details/leconcordatde15101thomuoft/page/n11 Le concordat de 1516, ses origines, son histoire au XVIe siècle] (Paris: Picard 1910), pp. 307–343.
• February 21 – Sir Edward Poynings becomes England's ambassador to Spain a second time and meets with King Carlos I to negotiate a treaty.{{Cite ODNB |last=Ellis |first=Steven G. |id=22683 |title=Poynings, Sir Edward |year=2004}}
• February 25 – In his capacity as Lord of Ireland, Henry VIII opens the first of six assemblies of parliament during his reign of the Parliament of Ireland at Dublin. The parliament holds three sessions, ending on October 2, when it is dismissed.
• March 1 – Desiderius Erasmus publishes a new Greek edition of the New Testament, Novum Instrumentum omne, in Basel.{{cite book |last1=Bruce |first1=Archibald Kay |title=Erasmus and Holbein |date=1936 |publisher=F. Muller |page=16 |url=https://books.google.com/books?id=B-YeAAAAMAAJ&q=%221%20march%201516%22 |access-date=17 July 2023 |language=en}}
• March 13 – At the age of 9, Louis II of Jagiellon becomes the new King of Hungary, Croatia and Bohemia upon the death of his father, King Vladislaus II.{{Cite EB1911|wstitle= Louis II. of Hungary | volume= 17 |last= Bain |first= Robert Nisbet |author-link= Robert Nisbet Bain| pages = 49–50 |short= 1 }}
• March 29 – The Venetian Ghetto is instituted in the Republic of Venice.{{cite book |last1=Davis |first1=Robert C. |last2=Ravid |first2=Benjamin |title=The Jews of Early Modern Venice |date=28 March 2001 |publisher=JHU Press |isbn=978-0-8018-6512-1 |page=8 |url=https://books.google.com/books?id=JejQqwa5Q94C&dq=Venetian+Ghetto+%2229+march+1516%22+republic+of+venice&pg=PA8 |access-date=17 July 2023 |language=en}}

• April 19 – England, represented by Ambassador Poynings and Spain's King Carlos I conclude a treaty of alliance.
• April 23 – The Reinheitsgebot is instituted in Ingolstadt, Bavaria, regulating the purity of beer permissible for sale.{{cite journal |last1=Drewes |first1=Michael |title=Hopfen und Malz, Gott erhalt's : eine kleine Ökonomik des Biers zum 500. Geburtstag des Reinheitsgebots |journal=Wirtschaftswissenschaftliches Studium |date=December 2016 |volume=45 |issue=12 |pages=652–656 |doi=10.15358/0340-1650-2016-12-652 |url=https://www.econbiz.de/Record/hopfen-und-malz-gott-erhalt-s-eine-kleine-%C3%B6konomik-des-biers-zum-500-geburtstag-des-reinheitsgebots-drewes-michael/10011703547 |access-date=17 July 2023|url-access=subscription }}
• May 6 – A Category IX earthquake strikes Dubrovnik in what is now Croatia.{{cite book | chapter-url = https://www.pilar.hr/wp-content/images/stories/dokumenti/zbornici/40/mpd_knjiga_265.pdf | language = hr | first1 = Davorka | last1 = Herak | first2 = Marijan | last2 = Herak | chapter = Seizmičnost i potresna opasnost na makarskom području | series = Biblioteka Zbornici | volume = 40 | title = Makarsko primorje danas. Makarsko primorje od kraja Drugog svjetskog rata do 2011. | editor-first1 = Marko | editor-last1 = Mustapić | editor-first2 = Ivan | editor-last2 = Hrstić | publisher = Institut društvenih znanosti Ivo Pilar | location = Zagreb | year = 2012 | isbn = 978-953-6666-87-4|page=271}}
• May 8 – In what is now Vietnam, Le Tuong Duc, Emperor of Dai Viet, since 1509, is murdered at his palace at Thang Long (now in Hanoi) by his bodyguards. Le Tuong Duc's 12-year-old nephew, Le Chieu Tong, is installed as the new Emperor by the conspirators.{{Citation|author=Đại Việt's Office of History|title=Đại Việt sử ký toàn thư|edition=Nội các quan bản|year=1993|language=vi|publisher=Social Science Publishing House|location=Hanoi}}
• June 14 – In Spain, King John III of Navarre dies after a reign of 32 years and is succeeded by his widow, Queen Catherine.{{cite book |title=The Queens Regnant of Navarre |first=Elena |last=Woodacre |publisher=Palgrave Macmillan |year=2013 }}

• July 4 – King James V of Scotland opens the Scottish Parliament at Edinburgh.
• July 28 – Selim I of the Ottoman Empire captures the city of Malatya (located in what is now southeastern Turkey) as the first conquest in his war against the Mamluk Sultanate of Egypt and then proceeds to invade Syria.{{cite book |last1=Mauder |first1=Christian |title=In the Sultan's Salon: Learning, Religion, and Rulership at the Mamluk Court of Qāniṣawh al-Ghawrī (r. 1501–1516) |date=4 June 2021 |publisher=Brill |isbn=978-90-04-44421-8 |pages=98–99 |chapter-url=https://brill.com/display/book/9789004444218/BP000002.xml |access-date=17 July 2023 |language=en |chapter=Historical Context and State of Research}}
• July 30 – John V, Count of Nassau-Siegen dies in Siegen, now in Germany, leaving his realm to be divided by his two sons. The transition is smooth because of a 1509 agreement between Henry III of Nassau-Breda and William I of Nassau-Dillenburg. William receives all of John V's possessions in Germany, while Henry inherits those in the Low Countries.{{Cite book |title=Nederlandse historische bronnen 4 · dbnl |last=Kluiver |first=J.H. |publisher=DBNL |date=1984 |access-date=15 August 2022 |url=https://www.dbnl.org/tekst/_ned017198401_01/_ned017198401_01_0002.php |archiveurl=https://web.archive.org/web/20220815191551/https://www.dbnl.org/tekst/_ned017198401_01/_ned017198401_01_0002.php|archivedate=2022-08-15 |language=nl |page=9}}
• August 13 – The Treaty of Noyon is signed. King François I of France recognizes Charles I of Spain's claim to Naples, and Charles recognizes Francis's claim to Milan. The treaty also promised Louise of France to Charles.{{cite book |title=Collection des ordonnances des rois de France: Catalogue des actes de François Ier |date=1887 |publisher=Imprimerie nationale |location=Pairs |page=85 |url=https://archive.org/details/collectiondesord01acad/page/84/mode/2up?q=%2213+aout%22 |access-date=17 July 2023}}
• August 18 – King Francis I of France and Pope Leo X sign the Concordat of Bologna, agreeing on the relationship between church and state in France.{{cite book |last1=Knecht |first1=R. J. |title=Francis I |date=26 April 1984 |publisher=Cambridge University Press |isbn=978-0-521-27887-4 |page=55 |url=https://books.google.com/books?id=rvEBMIIcHQkC&dq=%2218+august+1516%22+Concordat+of+Bologna&pg=PA55 |access-date=17 July 2023 |language=en}}
• August 24 – Ottoman–Mamluk War (1516–17): The Ottoman Sultan Selim I defeats the Mamluk forces commanded by the sultan Al-Ashraf Qansuh al-Ghuri in the Battle of Marj Dabiq, bringing all of the Middle East.{{cite book |title=Journal of the American Research Center in Egypt |date=1978 |volume=15|publisher=American Research Center in Egypt |page=80 |url=https://books.google.com/books?id=BbTiAAAAMAAJ&q=%2224%20august%201516%22 |access-date=17 July 2023 |language=en}} The Mamluk Sultan, Al-Ashraf Qansuh al-Ghuri, is killed while leading his troops in the battle, and Prime Minister Al-Ashraf Tuman Bay, who was left in charge in Cairo by the Sultan Qansuh, becomes the Sultan of Egypt, the last remaining part of the Mamluk Sultanate.
• September 16 – German theologian Andreas Karlstadt completes his series of 151 theses, an attack against corruption in the Roman Catholic Church.{{cite EB1911|wstitle=Carlstadt|volume=5|pages=348–349}}
• September 17 – Baased in Kamaran, an island in the Red Sea, the Mamluk Egyptian Admiral Selman Reis leads of fleet 19 ships in an unsuccessful attempt to take Yemen and Aden.[https://books.google.com/books?id=Ovg_RQlklU4C&pg=PA321 An Economic and Social History of the Ottoman Empire, Volume 1], by Halil İnalcik p.321ff

• October 28 – Ottoman–Mamluk War (1516–17): Ottoman forces under the Grand Vizier Sinan Pasha defeat the Mamluks in the Battle of Yaunis Khan near Gaza.
• November 29 – The "Treaty of Perpetual Peace" is signed in the city of Fribourg in Switzerland, between representatives of the Thirteen Cantons of the Old Swiss Confederacy, and King Francis of the Kingdom of France, confirming the French victory in the 1515 Battle of Marignano. The Swiss Confederacy renounces all claims to the French protectorate of Milan in Italy, in for 700,000 gold crowns in compensation.{{HLS|8898|Ewiger Frieden / Paix perpétuelle|author= André Holenstein |date=2010}}
• December 4 – Treaty of Brussels: Peace is declared between the Kingdom of France and the Holy Roman Empire.{{cite book |last1=Sporschil |first1=Johann |title=Die Geschichte der Deutschen von den ältesten Zeiten bis auf unsere Tage |date=1859 |publisher=G.J. Manz |page=546 |url=https://books.google.com/books?id=2ms_AAAAYAAJ&dq=Vertrag+von+Br%C3%BCssel+%E2%80%9E4.+Dezember+1516%E2%80%9C&pg=PA536 |access-date=17 July 2023 |language=de}}
• c. December – Thomas More's most famous work, Utopia, completed this year, is published in Leuven (in Latin).{{cite journal |last1=Morrish |first1=Jennifer |title=A Note on the Neo-Latin Sources for the Word 'Utopia' |journal=Humanistica Lovaniensia |date=2001 |volume=50 |pages=119–130 |jstor=23973826 |url=https://www.jstor.org/stable/23973826 |access-date=17 July 2023 |issn=0774-2908}}

• Italian explorer Rafael Perestrello, a cousin of the wife of Christopher Columbus, commands an expedition from Portuguese Malacca to land on the shores of mainland southern China, and trade with Chinese merchants at Guangzhou, during the Ming Dynasty.
• Portuguese soldier Fernão Lopes becomes the first known permanent inhabitant of Saint Helena.
• Leonardo da Vinci accepts Francis I's invitation to France.{{cite book |last1=Isaacson |first1=Walter |title=Leonardo da Vinci |date=17 October 2017 |publisher=Simon and Schuster |isbn=978-1-5011-3917-8 |page=497 |url=https://books.google.com/books?id=67KuDgAAQBAJ&dq=Leonardo+da+Vinci+francis+i+invitation++%221516%22&pg=PA497 |access-date=18 July 2023 |language=en}}
• The predecessor of the Royal Mail, known as the Master of the Posts, is established by Henry VIII of England.{{cite web |title=Postmasters General |url=https://gbps.org.uk/information/downloads/postal-museum/BPMA_Info_Sheet_Postmasters_General_web.pdf |website=gbps.org.uk |access-date=18 July 2023}}
• Gillingham School is founded, the oldest in Dorset, England.
• Fuggerei is established in Augsburg (Bavaria), as the world's oldest social housing complex still in use.{{cite thesis |last=Kovačić |first=Nedeljko |date=2015 |title=The Impact of Corporate Social Responsibility on Sustainable Cultural Communities |url=http://www.culturalmanagement.ac.rs/uploads/research_file_1/72b2519614d526a13d18f7f1e92ac1b46e3d2638.pdf |type=MA |chapter=Introduction|page=22 |publisher=University of Arts in Belgrade |access-date=18 July 2023}}
• The fall of the Nantan meteorite is possibly observed near the city of Nantan, Nandan County, Guangxi (China).{{cite journal |last1=Dekan |first1=Július |title=Composition of iron-bearing phases in Nantan meteorite as determined by Mössbauer spectrometry |journal=AIP Conference Proceedings |series=Applied Physics of Condensed Matter (Apcom 2021) |date=November 2, 2021 |volume=2411 |issue=1 |page=050002 |doi=10.1063/5.0067402 |bibcode=2021AIPC.2411e0002D |s2cid=242069262 |url=https://pubs.aip.org/aip/acp/article-abstract/2411/1/050002/686954/Composition-of-iron-bearing-phases-in-Nantan?redirectedFrom=fulltext |access-date=18 July 2023|quote=Nantan meteorite was found in 1958 and its fall might have been observed in 1516.|doi-access=free |url-access=subscription }}

File:Margareta Leijonhufvud.jpg]]

File:Jean Clouet Charlotte of France MIA 35798.jpg]]

• January 1 – Margaret Leijonhufvud, queen of Gustav I of Sweden (d. 1551){{cite web |title=Margareta |url=https://sok.riksarkivet.se/sbl/Presentation.aspx?id=9099 |website=sok.riksarkivet.se |access-date=18 July 2023}}
• January 14 – Herluf Trolle, Danish admiral (d. 1565){{cite book |title=Annaler for nordisk Oldkyndighed, udgivne af det kongelige nordiske Oldskrift-Selskab |date=1856 |publisher=L. Levin |location=Copenhagen |page=212 |url=https://books.google.com/books?id=ZYlfAAAAcAAJ&dq=Herluf+Trolle+%2214+januar+1516%22&pg=PA212 |access-date=18 July 2023 |language=da}}
• January 16 – Bayinnaung, King of Burma (d. 1581)
• February 2 – Girolamo Zanchi, Italian theologian (d. 1590){{cite book |last1=Zanchi |first1=Girolamo |last2=Baschera|first2=Luca|last3=Moser|first3=Christian|title=Girolamo Zanchi, De Religione Christiana Fides – Confession of Christian Religion |date=11 May 2007 |publisher=BRILL |isbn=978-90-04-16118-4 |page=1 |url=https://books.google.com/books?id=NkEmv7FDA94C&q=1516 |access-date=18 July 2023 |language=en}}
• February 16 – Prospero Spani, Italian sculptor (d. 1584){{cite web |title=Spani, Prospero |url=https://www.oxfordartonline.com/benezit/display/10.1093/benz/9780199773787.001.0001/acref-9780199773787-e-00172999 |website=Benezit Dictionary of Artists |access-date=18 July 2023 |language=en}}
• February 18 – Queen Mary I of England, daughter of King Henry VIII of England and Queen Catherine of Aragon (d. 1558){{cite book|author=Alison Plowden|title=The House of Tudor|url=https://books.google.com/books?id=y1dnAAAAMAAJ|year=1976|publisher=Stein and Day|isbn=978-0-8128-2079-9|page=223}}
• March 15 – Alqas Mirza, Safavid prince (d. 1550){{cite encyclopedia | title = ALQĀS MĪRZA | last = Fleischer | first = C. | url = http://www.iranicaonline.org/articles/alqas-alqasb-alqas-mirza-safawi | encyclopedia = Encyclopaedia Iranica, Vol. I, Fasc. 9 | pages = 907–909 | year = 1989 }}
• March 26 – Conrad Gessner, Swiss naturalist (d. 1565){{cite book|last=Bay|first=Jens Christian|title=Conrad Gesner (1516–1565), the Father of Bibliography: An Appreciation|url=https://books.google.com/books?id=iWkhAQAAMAAJ|year=1963|orig-year=1916 Bibliographical Society of America|publisher=Kraus Reprint Corporation}}
• April 16 – Tabinshwehti, King of Burma (d. 1550)
• April 23 – Georg Fabricius, Protestant German poet (d. 1571){{cite book |title=Allgemeine Encyclopädie der Wissenschaften und Künste |date=1844 |volume=1|publisher=Brockhaus |page=78 |url=https://books.google.com/books?id=64Kory57or0C&dq=Georg+Fabricius+%2223+april+1516%22&pg=RA1-PA78 |access-date=18 July 2023 |language=de}}
• June 28 – Charles Blount, 5th Baron Mountjoy, English courtier and patron of learning (d. 1544){{cite ODNB |title=Blount, Charles, fifth Baron Mountjoy (1516–1544), courtier and patron of learning |url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-2682?docPos=1 |year=2004 |access-date=18 July 2023 |language=en |doi=10.1093/ref:odnb/2682}}
• July 27 – Emilie of Saxony, German nobleman (d. 1591){{cite book |last1=Stichart |first1=Franz Otto |title=Galerie der sächsischen Fürstinnen: biographische Skizzen sämmtlicher Ahnfrauen des königlichen Hauses Sachsen |date=1857 |publisher=Fleischer |page=233 |url=https://books.google.com/books?id=XH8AAAAAcAAJ&dq=Aemilia+von+Sachsen+%2227+juli+1516%22&pg=PA233 |access-date=18 July 2023 |language=de}}
• July 28 – William, Duke of Jülich-Cleves-Berg, German nobleman (d. 1592){{cite book |last1=Knapp |first1=Johann F. |title=Regenten- und Volks-Geschichte der Länder Cleve, Mark, Jülich, Berg und Ravensberg Von Karl dem Großen bis auf ihre Vereinigung mit der Preußischen Monarchie (von 768 - 1815) |date=1836 |publisher=Becker |page=127 |url=https://books.google.com/books?id=xXAAAAAAcAAJ&dq=Wilhelm+%2228+juli+1516%22&pg=PA127 |access-date=18 July 2023 |language=de}}
• August 13 – Hieronymus Wolf, German historian (d. 1580){{cite book |title=Ex libris: Buchkunst und angewandte Graphik |date=1894 |publisher=Druck von O. Holten |location=Gorlitz |page=46 |url=https://books.google.com/books?id=o58aAAAAYAAJ&dq=Hieronymus+Wolf+%2213+august+1516%22&pg=PA44 |access-date=18 July 2023 |language=de}}
• September 2 – Francis I, Duke of Nevers (d. 1561){{cite book |title=Les ducs de Nevers et l'État royal: genèse d'un compromis (ca 1550 - ca 1600) |first=Ariane |last=Boltanski |language=French |publisher=Librairie Droz |year=2006 }}
• September 21 – Matthew Stewart, 4th Earl of Lennox (d. 1571){{cite book |last1=Paul |first1=James Balfour |title=The Scots Peerage |date=1908 |publisher=D. Douglas |page=353 |url=https://books.google.com/books?id=ErEEAAAAIAAJ&dq=Matthew+Stewart,+4th+Earl+of+Lennox+%2221+september+1516%22&pg=PA353 |access-date=18 July 2023 |language=en}}
• October 23 – Charlotte of Valois, French princess (d. 1524){{cite book |last1=Houdard |first1=Georges |title=Les Châteaux Royaux de Saint-Germain-en-Laye 1124-1789: étude historique d'après des documents inédits, recueillis aux Archives Nationales et à la Bibliothèque Nationale |date=1910 |publisher=M. Mirvault |page=37 |url=https://books.google.com/books?id=BuJYAAAAYAAJ&dq=Charlotte+de+France+%2223+octobre+1516%22&pg=RA1-PA37 |access-date=18 July 2023 |language=fr}}
• October 27 – Ruy Gómez de Silva, Portuguese noble (d. 1573)
• November 5 – Martin Helwig, German cartographer of Silesia (d. 1574){{cite book |last1=Karrow |first1=Robert W. |title=Mapmakers of the Sixteenth Century and Their Maps |date=1993 |publisher=Newberry Library |isbn=978-0-932757-05-0 |page=288 |url=https://books.google.com/books?id=BuMRAQAAIAAJ&q=%225%20november%201516%22 |access-date=18 July 2023 |language=en}}
• December 21 – Giuseppe Leggiadri Gallani, Italian poet and dramatist (d. 1590){{cite web |last1=Rosa |first1=Angela Asor |title=GALLANI, Giuseppe Leggiadro |url=https://www.treccani.it/enciclopedia/giuseppe-leggiadro-gallani_(Dizionario-Biografico) |website=www.treccani.it |access-date=18 July 2023 |language=it-IT}}
• date unknown
• John Foxe, biographer (d. 1587){{cite ODNB |title=Foxe, John |url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-10050 |year=2004 |access-date=18 July 2023 |language=en |doi=10.1093/ref:odnb/10050}}
• Manco Inca Yupanqui, ruler of the Inca (d. 1544){{cite book |last1=Seaman |first1=Rebecca M. |title=Conflict in the Early Americas: An Encyclopedia of the Spanish Empire's Aztec, Incan, and Mayan Conquests |date=27 August 2013 |publisher=ABC-CLIO |isbn=978-1-59884-777-2 |page=228 |url=https://books.google.com/books?id=IXKjAQAAQBAJ&dq=Manco+Inca+Yupanqui+%221516%22&pg=PA228 |access-date=18 July 2023 |language=en}}
• Canghali of Kazan, khan of Qasim and Kazan (d. 1535){{cite book |last1=Muslimov |first1=Ilʹi︠a︡z Bulatovich |title=На стыке континентов и цивилизаций--: из опыта образования и распада империи X-XVI вв |date=1996 |publisher=ИНСАН |isbn=978-5-85840-280-0 |page=587 |url=https://books.google.com/books?id=ywQXAQAAIAAJ&q=%221516%22 |access-date=18 July 2023 |language=ru}}
• Margaretha Coppier, Dutch heroine (d. 1597){{cite book |last1=der Aa |first1=Abraham Hans van |title=Biographisch woordenboek der Nederlanden |date=1858 |volume=3|publisher=J.J. van Brederode |location=Haarlem|page=218 |url=https://books.google.com/books?id=jvtIogBQUwQC&dq=Margaretha+Coppier+%221516%22&pg=PA218 |access-date=18 July 2023 |language=nl}}

File:Michel Sittow 004.jpg]]

File:Vladislaus II of Bohemia and Hungary.jpg]]

• January 20 – Juan Díaz de Solís, Spanish navigator and explorer (b. 1470){{cite book |last1=Lewis |first1=Daniel K. |title=The History of Argentina |date=15 October 2003 |publisher=Palgrave Macmillan |isbn=978-1-4039-6254-6 |page=20 |url=https://books.google.com/books?id=_mPgCgAAQBAJ&dq=Juan+D%C3%ADaz+de+Sol%C3%ADs+%22january+20+1516%22&pg=PA20 |access-date=18 July 2023 |language=en}}
• January 23 – King Ferdinand II of Aragon (b. 1452){{cite web |title=Ferdinand II {{!}} Biography & Facts |url=https://www.britannica.com/biography/Ferdinand-II-king-of-Spain |website=Encyclopedia Britannica |access-date=30 June 2020 |language=en}}
• February 4 – Anthony of Supraśl, Polish Orthodox priest and saint{{cite journal |last1=Mironowicz |first1=Antoni |title=Św. Antoni Supraski |url=https://repozytorium.uwb.edu.pl/jspui/handle/11320/3480 |journal=Elpis: Czasopismo Teologiczne Katedry Teologii Prawosławnej Uniwersytetu W Białymstoku |access-date=18 July 2023 |pages=11–24 |language=pl |doi=10.15290/elpis.2015.17.02 |date=2015|volume=17 |doi-access=free }}
• March 13 – Vladislaus II, king of Bohemia, Hungary and Croatia (b. 1456){{cite journal |last1=von Güttner Sporzynski |first1=Darius |title=Contextualising the marriage of Bona Sforza to Sigismund I of Poland: Maximilian I's diplomacy in Italy and Central Europe |journal=Folia Historica Cracoviensia |date=1 January 2022 |volume=27 |issue=2 |pages=63–90 |doi=10.15633/fhc.4200 |s2cid=255899688 |url=https://acuresearchbank.acu.edu.au/item/8y2yv/contextualising-the-marriage-of-bona-sforza-to-sigismund-i-of-poland-maximilian-i-s-diplomacy-in-italy-and-central-europe |language=en|doi-access=free }}
• March 17 – Giuliano de' Medici, Duke of Nemours, ruler of Florence (b. 1449){{cite book |last1=Jungić |first1=Josephine |title=Giuliano de' Medici: Machiavelli's Prince in Life and Art |date=13 April 2018 |publisher=McGill-Queen's Press |isbn=978-0-7735-5369-9 |page=1 |url=https://books.google.com/books?id=PJ1WDwAAQBAJ&q=%2217%20march%201516%22 |access-date=18 July 2023 |language=en}}
• April 25 – John Yonge, English diplomat (b. 1467){{cite book |last1=Lee |first1=Sidney |title=Dictionary of National Biography: Wordsworth - Zuylestein |date=1900 |volume=LXIII|publisher=Smith, Elder, & Co |location=London |page=328 |url=https://books.google.com/books?id=znIqYmlMF_MC&dq=John+Yonge+%2225+april+1516%22&pg=PA328 |access-date=18 July 2023 |language=en}}
• June 14 – King John III of Navarre (b. 1469){{cite book |last1=Lacarra |first1=José María |title=Historia del reino de Navarra en la Edad Media |date=1975 |publisher=Caja de Ahorros de Navarra |isbn=978-84-500-7465-9 |page=552 |url=https://books.google.com/books?id=uhhpAAAAMAAJ&q=%2217%20junio%201516%22 |access-date=18 July 2023 |language=es}}
• July 10 – Alice FitzHugh, English heir (b. 1448)
• July 30 – John V, Count of Nassau-Siegen, German count (b. 1455){{cite book |last1=Ersch |first1=Johann Samuel |last2=Gruber |first2=Johann Gottfried |title=Allgemeine Enzyklopädie Der Wissenschaften und Künste |date=1982 |volume=21|publisher=Akademische Druck-u. Verlagstalt |isbn=978-3-201-00093-2 |page=138 |url=https://books.google.com/books?id=jC9NAAAAYAAJ&q=%20%2230%20juli%201516%22 |access-date=18 July 2023 |language=de}}
• August 9 (bur.) – Hieronymus Bosch, Dutch painter (b. 1450){{cite book|author=Walter Bosing|title=Hieronymus Bosch, C. 1450-1516: Between Heaven and Hell|url=https://books.google.com/books?id=hCXN3R4_vpYC&pg=PA14|year=2000|publisher=Taschen|isbn=978-3-8228-5856-1|pages=14|language=en}}
• August 21 – John III of Egmont, Dutch count (b. 1438)
• August 24 – Al-Ashraf Qansuh al-Ghuri, Mamluk sultan (b. c. 1441){{cite book |last1=Holt |first1=Peter Malcolm |last2=Lambton |first2=Ann K. S. |last3=Lewis |first3=Bernard |title=The Cambridge History of Islam |date=1978 |volume=2|publisher=Cambridge University Press |isbn=978-0-521-29135-4 |page=318 |url=https://books.google.com/books?id=4AuJvd2Tyt8C&dq=al-Ghawri+%2224+august+1516%22&pg=PA318 |access-date=18 July 2023 |language=en}}
• October 30 – Louis Malet de Graville, Admiral of France, politician, military leader and art patron (b. c. 1440).{{cite book |last1= Deldicque|first1= Mathieu|last2= Leprêtre|first2= Elisabeth|date= 2017|title= Être mécène à l'aube de la Renaissance : l'amiral Louis Malet de Graville|language= French|location= Ghent|publisher= Snoeck|isbn= 9789461613950|url=https://search.worldcat.org/title/1004773445|page=23}}
• November 26 – Giovanni Bellini, Venetian painter (b. 1430){{cite book |last1=Bätschmann |first1=Oskar |title=Giovanni Bellini |date=2008 |publisher=Reaktion Books |isbn=978-1-86189-357-4 |page=16 |url=https://books.google.com/books?id=L7QtmU7JRrQC&q=%20%2229%20november%201516%22 |access-date=18 July 2023 |language=en}}
• December 13 – Johannes Trithemius, German scholar and cryptographer (b. 1462){{cite book |last1=Arnold |first1=Klaus |title=Johannes Trithemius (1462-1516) |date=1991 |publisher=Kommissionsverlag F. Schöningh |isbn=978-3-87717-045-8 |page=223 |url=https://books.google.com/books?id=TTsvAAAAYAAJ&q=%2213%20dezember%201516%22 |access-date=18 July 2023 |language=de}}
• date unknown – Giuliano da Sangallo, Florentine sculptor and architect (b. 1443){{cite book |last1=Brothers |first1=Cammy |title=Giuliano da Sangallo and the Ruins of Rome |date=25 January 2022 |publisher=Princeton University Press |isbn=978-0-691-22652-1 |page=142 |url=https://books.google.com/books?id=a545EAAAQBAJ&q=%221516%22 |access-date=18 July 2023 |language=en}}

{{reflist}}

{{DEFAULTSORT:1516}}