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1521

{{About year|1521}}

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File:Лютер в Вормсе.jpg: The Diet of Worms parliament is opened by Emperor Charles V in the German city of Worms.]]

{{C16 year in topic}}

1521 (MDXXI) was a common year starting on Tuesday of the Julian calendar, the 1521st year of the Common Era (CE) and Anno Domini (AD) designations, the 521st year of the 2nd millennium, the 21st year of the 16th century, and the 2nd year of the 1520s decade.

Events

File:Scrisoarea-lui-neacsu-din-campulung.jpg, the oldest surviving document written in Romanian has the oldest appearance of the word "Rumanian"]]

= January–March =

  • January 3 – Pope Leo X excommunicates Martin Luther, in the papal bull Decet Romanum Pontificem.{{cite book|author=Michael M. Tavuzzi|title=Prierias: The Life and Works of Silvestro Mazzolini Da Prierio, 1456-1527|url=https://books.google.com/books?id=V58f64kc4EQC&pg=PA80|year=1997|publisher=Duke University Press|isbn=0-8223-1976-4|pages=80}}
  • January 22 – Charles V, Holy Roman Emperor, opens the Diet of Worms in Worms, Germany.{{cite book|author1=Hugh Chisholm|author2=James Louis Garvin|title=The Encyclopædia Britannica: A Dictionary of Arts, Sciences, Literature & General Information|url=https://books.google.com/books?id=i4dGAQAAIAAJ|year=1926|publisher=Encyclopædia Britannica Company|page=137}}
  • January 27 – Suleiman the Magnificent suppresses a revolt by the ruler of Damascus, Janbirdi al-Ghazali.{{cite book |last1=Pitcher |first1=Donald Edgar |title=An Historical Geography of the Ottoman Empire: From Earliest Times to the End of the Sixteenth Century |date=1972 |publisher=Brill Archive |page=113 |url=https://books.google.com/books?id=8gs4AAAAIAAJ&q=january |access-date=25 July 2023 |language=en}}
  • February 2 – The Nydala Abbey Bloodbath takes place at Nydala Abbey, Sweden; the abbot and many monks are murdered by Danes.{{cite book|title=The Downside Review|url=https://books.google.com/books?id=qQ5OAQAAIAAJ|year=1970|publisher=Downside Abbey|page=284}}
  • March 6
  • Ferdinand Magellan makes the first European contact with Guam,{{cite book |title=Annual Economic Review and Statistical Abstract, Guam |date=1994 |publisher=Economic Research Center, Department of Commerce |page=1 |url=https://books.google.com/books?id=hDO0AAAAIAAJ&q=%20%22first%20european%22%20march%206%201521 |access-date=25 July 2023 |language=en}} most likely landing in Tumon.{{cite journal |last1=Rogers |first1=Robert F. |last2=Ballendorf |first2=Dirk Anthony |title=Magellan's Landfall in the Mariana Islands |journal=The Journal of Pacific History |date=1989 |volume=24 |issue=2 |pages=193–208 |doi=10.1080/00223348908572614 |jstor=25169001 |url=https://www.jstor.org/stable/25169001 |access-date=25 July 2023 |issn=0022-3344|url-access=subscription }}
  • Martin Luther is summoned to appear before the Diet of Worms.{{cite book |last1=Gritsch |first1=Eric W. |title=Martin - God's Court Jester: Luther in Retrospect |date=1 May 2009 |publisher=Wipf and Stock Publishers |isbn=978-1-60608-637-7 |page=40 |url=https://books.google.com/books?id=5B5MAwAAQBAJ&dq=Martin+Luther+diet+of+worms+%226+march+1521%22&pg=PA40 |access-date=25 July 2023 |language=en}}
  • March 16 – Ferdinand Magellan reaches the Philippines, in eastern Samar.{{cite book |last1=Arcilla |first1=José S. |title=An Introduction to Philippine History |date=1998 |publisher=Ateneo University Press |isbn=978-971-550-261-0 |page=1 |url=https://books.google.com/books?id=uxEYobbU-D8C&dq=%2216+march+1521%22+ferdinand+magellan+philippines&pg=PA1 |access-date=25 July 2023 |language=en}}
  • March 31 – The First Mass in the Philippines is held.{{cite book|author=Rosario Mendoza Cortes|title=The Filipino Saga: History as Social Change|url=https://books.google.com/books?id=7hdwAAAAMAAJ|year=2000|publisher=New Day Publishers|isbn=978-971-10-1055-3|page=29}}

= April–June =

  • April 7
  • Ferdinand Magellan arrives at Cebu.{{cite book |last1=Aluit |first1=Alphonso J. |title=The Philippines: Comprehensive, Authoritative, Up-to-date |date=1990 |publisher=Solar Publishing Company |isbn=978-971-17-0637-1 |page=305 |url=https://books.google.com/books?id=GWZxAAAAMAAJ&q=%227%20april%201521%22 |access-date=25 July 2023 |language=en}}
  • Martin Luther preaches an inflammatory sermon to students at Erfurt, while on his way to Worms.{{cite book |last1=Old |first1=Hughes Oliphant |title=The Reading and Preaching of the Scriptures in the Worship of the Christian Church, Volume 4: The Age of the Reformation |date=2 May 2002 |publisher=Wm. B. Eerdmans Publishing |isbn=978-0-8028-4775-1 |page=7 |url=https://books.google.com/books?id=jhw1eKcDtHYC&q=%227+april%22 |access-date=25 July 2023 |language=en}}
  • April 16–18 – Martin Luther is examined before Emperor Charles V and the Diet of Worms, where he refuses to recant his writings and allegedly proclaims, "Here I stand", regarding his belief in the Bible alone, as the standard of Christian doctrine.
  • April 23 – Revolt of the Comuneros – Battle of Villalar: Castilian royalists defeat the rebels.{{cite book |last1=Haliczer |first1=Stephen |title=The Comuneros of Castile : the forging of a revolution, 1475-1521 |date=1981 |publisher=University of Wisconsin Press |location=Madison |isbn=978-0-299-08500-1 |page=204 |url=https://archive.org/details/comunerosofcasti0000hali/page/204/mode/2up?q=%22april+23%22 |access-date=25 July 2023}} Juan López de Padilla, Francisco Maldonado, and Juan Bravo are executed the following day as the leaders of the rebels.
  • April 26 – Martin Luther leaves Worms and disappears for around a year{{cite web |title=HISTORY OF THE CHRISTIAN CHURCH* |url=https://www.ccel.org/s/schaff/history/7_ch04.htm |website=www.ccel.org |access-date=25 July 2023}} – he is rumored to be murdered, but is actually in hiding at the Wartburg castle.{{cite book |last1=Saxl |first1=Fritz |title=A heritage of images: a selection of lectures |date=1970 |publisher=Penguin Books |location=Harmondsworth |isbn=978-0-14-055088-7 |page=112 |url=https://archive.org/details/heritageofimages0000saxl/page/112/mode/2up?q=%2226+april%22 |access-date=25 July 2023}}
  • April 27 – Battle of Mactan: Ferdinand Magellan is killed in the Philippines when he confronts Lapulapu, the chief of the island.{{cite journal |last1=Martínez-García |first1=Ángeles |last2=Gómez-Aguilar |first2=Antonio |title=Magallanes: Building a Hero |journal=Revista Latina de Comunicación Socia |date=2019 |volume=74 |pages=618–636 |url=https://www.proquest.com/openview/4e2cd8eca7b7e13b7c9b0034f79870a4/1?pq-origsite=gscholar&cbl=236244 |access-date=25 July 2023 |language=en}}
  • April or May – Battle of Tunmen in Tuen Mun (present-day Hong Kong): The Ming Dynasty navy defeats the Portuguese navy{{cite book |last1=Hao |first1=Zhidong |title=Macau History and Society |date=1 January 2011 |publisher=Hong Kong University Press |isbn=978-988-8028-54-2 |pages=11–12 |url=https://books.google.com/books?id=LP9q1dzVRYQC&q=%22april%22+tunmen |access-date=25 July 2023 }} (arguably the first Sino-European battle in world history).
  • May 17 – Edward Stafford, 3rd Duke of Buckingham, is executed for treason in Tower Hill.{{cite journal |last1=Harris |first1=Barbara |title=The Trial of the Third Duke of Buckingham-A Revisionist View |journal=The American Journal of Legal History |date=1976 |volume=20 |issue=1 |pages=15–26 |doi=10.2307/844847 |jstor=844847 |url=https://www.jstor.org/stable/844847 |access-date=25 July 2023 |issn=0002-9319|url-access=subscription }}
  • May 20 – At the Battle of Pampeluna in Italy, and alliance of forces from French and the Kingdom of Navarre forces defeat those of Spain.{{cite book|title=Studies|url=https://books.google.com/books?id=JTrhAAAAMAAJ|year=1985|publisher=Studies|page=230}}
  • May 25 – The Diet of Worms ends when Charles V, Holy Roman Emperor issues the Edict of Worms, declaring Martin Luther an outlaw and banning his literature.{{cite book |last1=Darian-Smith |first1=Eve |title=Religion, Race, Rights: Landmarks in the History of Modern Anglo-American Law |date=20 May 2010 |publisher=Bloomsbury Academic |isbn=978-1-84113-729-2 |page=28 |url=https://books.google.com/books?id=xt4pAQAAMAAJ&q=%20outlaw |access-date=26 July 2023 |language=en}}
  • May 27 – After death of his cousin, Jiajing, Prince Zhu Houcong became the new Ming dynasty Emperor of China, taking the imperial name of the Emperor Jiajing becomes the new.{{cite book |last1=Geiss |first1=James |title=The Cambridge History of China|volume=7: The Ming Dynasty, 1368–1644 |date=1988 |publisher=Cambridge University Press |isbn=978-0-521-24332-2 |pages=440–510 |url=https://www.cambridge.org/core/books/abs/cambridge-history-of-china/chiaching-reign-15221566/60E9B518B7E3782006F9CC5DF0C4932D |access-date=26 July 2023 |chapter=The Chia-ching reign, 1522–1566}}
  • June 25 – Suleiman the Magnificent begins the siege of Belgrade.
  • June 29 or 30 – The oldest surviving dateable document written primarily in the Romanian language: Neacșu's letter, written by a trader from Câmpulung, to Johannes Benkner, the mayor of Brașov, warning that the Ottoman Empire is preparing its troops to cross into Wallachia and Transylvania; the script used is Romanian Cyrillic.
  • June 30 – Battle of Esquiroz: French forces under André de Foix, fighting for the exiled King of Navarre Henri d'Albret, are defeated by the Spanish, and forced to abandon their attempt to recover Henri's kingdom.{{cite book |last1=Soraluce |first1=Nicolás de |title=Historia de la m. n. y m. l. Provincia de Guipúzcoa |date=1864 |publisher=Joaquin Bernat |location=Madrid |page=241 |url=https://books.google.com/books?id=hl1BAAAAcAAJ&dq=Batalla+de+No%C3%A1in+Enrique+II+%2230+de+junio+de+1521%22&pg=PA241 |access-date=26 July 2023 |language=es}}

= July–September =

  • July 15 — San Juan Bautista is founded as the new capital of the archipelago of Puerto Rico.
  • August 13 – Fall of Tenochtitlan: Cuauhtémoc surrenders to Cortés,{{cite book |last1=Sheppard |first1=Si |title=Tenochtitlan 1519– 21. Clash Of Civilizations ( Si Sheppard) |date=2018 |publisher=Bloomsbury |page=87 |url=https://archive.org/details/tenochtitlan-1519-21.-clash-of-civilizations-si-sheppard-z-lib.org/page/86/mode/2up?q=%2213+august%22 |access-date=26 July 2023}} thus incorporating the Aztec Empire into the Spanish Empire and ending the Late Postclassic period in Mesoamerica.
  • August 20 – The Italian War of 1521–1526 breaks out between Charles V, Holy Roman Emperor, and Francis I of France as Henry III of Nassau-Breda leads Imperial troops on an invasion of northeastern France.{{cite book |last1=Frieda |first1=Leonie |author1-link=Leonie Frieda |title=Francis I: The Maker of Modern France |date=2018 |publisher=Orion |location=London |pages=132–133 |isbn=978-14746-0-558-8 |url=https://books.google.com/books?id=21M_DQAAQBAJ}}
  • August 29 – Belgrade is captured by the Ottoman army of Suleiman the Magnificent.{{cite book |last1=Wheatcroft |first1=Andrew |title=The Enemy at the Gate: Habsburgs, Ottomans, and the Battle for Europe |date=28 April 2009 |publisher=Basic Books |isbn=978-0-7867-4454-1 |page=9 |url=https://books.google.com/books?id=XkLDVyYZPBYC |access-date=26 July 2023 |language=en}}{{cite book |last1=Sarı |first1=İbrahim |title=TÜRK'ÜN SAVAŞLARI: Türklerin İslam Dünyasındaki Liderliği ve Savaşları |date=6 February 2013 |publisher=Kitapoku |isbn=978-605-4746-20-0 |page=216 |url=https://books.google.com/books?id=W-aVCwAAQBAJ&dq=belgrad+osmanl%C4%B1+s%C3%BCleyman+%2229+a%C4%9Fustos+1521%22&pg=PA216 |access-date=26 July 2023 |language=tr}}

= October–December =

  • October 25 – The Revolt of the Comuneros, an uprising by citizens of the Kingdom of Castile against the rule of Spain's King Carlos I, ends as the comuneros surrender Toledo.{{cite book |last=Seaver |first=Henry Latimer |author-link=Henry Latimer Seaver |title=The Great Revolt in Castile: A Study of the Comunero Movement of 1520–1521 |year=1928 |publisher=Octagon Books |location=New York |page=346 |ref=Sea28 }}
  • November 23 – Spanish–German–Papal forces under Prospero Colonna force French Marshal Odet de Lautrec to abandon Milan.
  • December 27 – The Zwickau prophets arrive in Wittenberg, disturbing the peace and spreading the idea of rejecting infant baptism.{{cite book |last1=Krentz |first1=Natalie |title=Ritualwandel und Deutungshoheit: Die frühe Reformation in der Residenzstadt Wittenberg (1500-1533) |date=14 March 2014 |publisher=Mohr Siebeck |isbn=978-3-16-152679-4 |page=205 |url=https://books.google.com/books?id=FVQGH70N6H4C&q=%2227+dezember%22 |access-date=26 July 2023 |language=de}}

= Date unknown =

  • Jacopo Berengario da Carpi publishes Commentaria cum amplissimus additionibus super anatomiam Mundini in Bologna, including observation of the vermiform appendix.{{cite book|author=Mary Agnes Burniston Brazier|title=The Historical Development of Neurophysiology|url=https://books.google.com/books?id=mUdQAQAAIAAJ|year=1959|publisher=American Physiological Society|page=4}}
  • The Grand Duchy of Ryazan is annexed by the Grand Duchy of Moscow.{{cite book |title=A short history of the USSR |date=1965 |publisher=Progress Publishers |location=Moscow |page=90 |url=https://archive.org/details/shorthistoryofus01inst/page/90/mode/2up?q=1521 |access-date=26 July 2023}}

Births

File:Maria von Portugal, Anthonis Mor.jpg]]

  • March 21 – Maurice, Elector of Saxony (d. 1553){{cite book |last1=Beach |first1=Frederick Converse |last2=Morgan |first2=Forrest |last3=Rines |first3=George Edwin |last4=Roe |first4=Edward Thomas |last5=Dole |first5=Nathan Haskell |last6=Copeland |first6=Thomas Campbell |title=The Encyclopedia Americana |date=1903 |publisher=Americana Company |page=94 |url=https://books.google.com/books?id=n9FCAQAAMAAJ&q=%20%2221%20march%201521%22 |access-date=26 July 2023 |language=en}}
  • April 5 – Francesco Laparelli, Italian architect (d. 1570){{cite book |title=Nuovo dizionario istorico |date=1791 |volume=XV|publisher=per Michele Morelli |location=Naples |page=218 |url=https://books.google.com/books?id=W95oiVI6nyUC&dq=Francesco+Laparelli+%225+aprile+1521%22&pg=PA218 |access-date=26 July 2023 |language=it}}
  • April 14 – Johann Marbach, German theologian (d. 1581){{cite book |last1=Horning |first1=Wilhelm |title=Dr. Johann Marbach, Pfarrer zu St. Nikolai, Münsterprediger, Professor und Präsident des Luth. Kirchenconvents in Strassburg, 1545-1581 |date=1887 |publisher=C.A. Vomhoff |location=Strasbourg |page=11 |url=https://books.google.com/books?id=NJLP60wdPSMC&q=%2214%20april%201521%22 |access-date=26 July 2023 |language=de}}
  • April 18 – François de Coligny d'Andelot, French general (d. 1569){{cite book |last1=Vindry |first1=Fleury |title=Dictionnaire de l'état-major français au XVIe siècle |date=1901 |publisher=Castanet |page=161 |url=https://books.google.com/books?id=idKajpeREDkC&dq=Fran%C3%A7ois+de+Coligny+d%27Andelot+%2218+avril+1521%22&pg=PA161 |access-date=26 July 2023 |language=fr}}
  • May 8 – Petrus Canisius, Dutch Jesuit (d. 1597){{cite web |title=St. Peter Canisius |url=https://www.newadvent.org/cathen/11756c.htm |website=www.newadvent.org |access-date=26 July 2023}}
  • May 10 – John Ernest, Duke of Saxe-Coburg, (d. 1553){{cite book |title=Allgemeine deutsche biographie |date=1881 |volume=14|publisher=Duncker und Humblot |page=369 |url=https://books.google.com/books?id=15SjLCe9htcC&dq=Johann+Ernst+%2210+mai+1521%22&pg=PA369 |access-date=26 July 2023 |language=de}}
  • June 8 – Maria of Portugal, Duchess of Viseu, daughter of King Manuel I (d. 1577){{cite book |last1=Vasconcellos |first1=Carolina Michaëlis de |title=A infanta D. Maria de Portugal (1521-1577) e suas damas |date=1902 |publisher=Typ. a vapor de A. J. de Souza & irmão |page=17 |url=https://books.google.com/books?id=kD5AAAAAYAAJ&dq=Maria+de+Portugal+%228+de+junho+de+1521%22&pg=PA17 |access-date=26 July 2023 |language=pt-BR}}
  • June 21 – John II, Duke of Schleswig-Holstein-Haderslev (d. 1580){{cite book |last1=Bricka |first1=Carl Frederik |title=Dansk biografisk lexikon |date=1892 |volume=6|publisher=F. Hegel & Søn |page=569 |url=https://books.google.com/books?id=97lAAAAAYAAJ&dq=Hans+den+%C3%86ldre+%2229+juni+1521%22&pg=PA569 |access-date=26 July 2023 |language=da}}
  • August 4 – Pope Urban VII (d. 1590){{cite book|author=Grolier Incorporated|title=The encyclopedia Americana|url=https://books.google.com/books?id=gWENAQAAMAAJ|year=1997|publisher=Grolier Incorporated|page=18|isbn=9780717201303}}
  • August 19 – Lodovico Guicciardini, Italian historian (d. 1589){{cite book |last1=Fantoni |first1=Marcello |title=Il Rinascimento italiano e l'Europa |date=2005 |publisher=Fondazione Cassamarca |isbn=978-88-89527-17-7 |page=165 |url=https://books.google.com/books?id=YOsWAQAAIAAJ&q=%2219%20agosto%201521%22 |access-date=26 July 2023 |language=it}}{{cite web |title=Guicciardini, Lodovico |url=https://www.oxfordartonline.com/groveart/display/10.1093/gao/9781884446054.001.0001/oao-9781884446054-e-7000035507 |website=Grove Art Online |year=2003 |access-date=26 July 2023 |language=en |doi=10.1093/gao/9781884446054.article.T035507}}
  • October 1 – Frederick Magnus I, Count of Solms-Laubach, (d. 1561)
  • November 21 – Edmund Sheffield, 1st Baron Sheffield, English baron (d. 1549){{cite ODNB |title=Sheffield, Edmund, first Baron Sheffield |url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-25292|year=2004 |access-date=26 July 2023 |language=en |doi=10.1093/ref:odnb/25292}}
  • November 29 – Marcantonio Maffei, Italian Catholic archbishop and cardinal (d. 1583){{cite web |title=The Cardinals of the Holy Roman Church - Biographical Dictionary - Consistory of May 17, 1570 |url=https://cardinals.fiu.edu/bios1570.htm#Maffei |website=cardinals.fiu.edu |access-date=26 July 2023}}
  • December 1 – Takeda Shingen, Japanese warlord (d. 1573)
  • December 13 – Pope Sixtus V (d. 1590){{cite book|title=RACAR, Revue D'art Canadienne: Canadian Art Review|url=https://books.google.com/books?id=EETrAAAAMAAJ|year=1990|publisher=Society for the Promotion of Art History Publications in Canada|page=18}}
  • date unknown
  • Anne Askew, English Protestant martyr (d. 1546){{cite book |last1=Zahl |first1=Paul |title=Five Women of the English Reformation |date=June 2001 |publisher=Wm. B. Eerdmans Publishing |isbn=978-0-8028-3045-6 |page=27 |url=https://books.google.com/books?id=1zQKcL9l-fsC&q=%221521%22 |access-date=26 July 2023 |language=en}}
  • John Aylmer, English divine (d. 1594){{cite ODNB |title=Aylmer, John|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-935|year=2004 |access-date=26 July 2023 |language=en |doi=10.1093/ref:odnb/935}}
  • Sue Harukata, Japanese retainer and later daimyō under Ōuchi Yoshitaka (d. 1555){{cite web |title=陶晴賢(すえはるかた)とは？ |url=https://kotobank.jp/word/%E9%99%B6%E6%99%B4%E8%B3%A2-83345 |website=コトバンク |access-date=27 July 2023 |language=ja}}
  • Thomas Chaloner, English statesman and poet (d. 1565){{cite book |last1=O'Sullivan |first1=Dan |title=The Reluctant Ambassador: The Life and Times of Sir Thomas Chaloner, Tudor Diplomat |date=15 May 2016 |publisher=Amberley Publishing Limited |isbn=978-1-4456-5165-1 |page=12 |url=https://books.google.com/books?id=oMV5DAAAQBAJ&q=1521 |access-date=27 July 2023 |language=en}}
  • Philippe de Monte, Flemish composer (d. 1603){{cite book |last1=Mann |first1=Brian Richard |title=The secular madrigals of Filippo di Monte, 1521-1603 |date=1983 |publisher=UMI Research Press |location=Ann Arbor |isbn=978-0-8357-1402-0 |page=1 |url=https://archive.org/details/secularmadrigals0000mann/page/n17/mode/2up?q=1521 |access-date=27 July 2023}}
  • Rokkaku Yoshikata, Japanese daimyō (d. 1598){{cite book |last1=Frederic |first1=Louis |title=Japan Encyclopedia |date=2002 |publisher=Harvard University Press |isbn=978-0-674-01753-5 |page=794 |url=https://books.google.com/books?id=p2QnPijAEmEC&dq=Rokkaku+Yoshikata+%221521%22&pg=PA794 |access-date=27 July 2023 |language=en}}
  • Thomas Wyatt the Younger, English rebel (d. 1554){{cite ODNB |title=Wyatt, Sir Thomas|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-30112|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/30112}}
  • possible
  • Catherine Howard, fifth queen of Henry VIII of England, (b. between 1518 and 1524; d. 1542){{cite ODNB |title=Katherine [Catherine] [née Katherine Howard]|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-4892|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/4892}}

Deaths

File:明武宗画像.jpg]]

File:Ferdinand Magellan.jpg]]

File:Juan Ponce de Leon.jpg]]

File:Margaret of Lorraine.jpg]]

File:Raffael 042.jpg]]

File:Manuel I1.jpg]]

File:Domenico Spadafora.jpg]]

  • January 6 – Cardinal William de Croÿ (b. 1497){{cite book |last1=Fisquet |first1=Honoré |title=La France pontificale |date=1864 |publisher=Etienne Repos |page=229 |url=https://books.google.com/books?id=oql2vG7C91AC&dq=Guillaume+de+Cro%C3%BF+%226+janvier+1521%22&pg=PA229 |access-date=27 July 2023 |language=fr}}
  • January 15 – John II, Duke of Cleves (b. 1458){{cite web |title=Johann II. |url=https://www.deutsche-biographie.de/gnd119135574.html#ndbcontent |website=www.deutsche-biographie.de |access-date=27 July 2023 |language=de}}
  • April 20 – Zhengde Emperor of China (b. 1491){{cite book |title=中国官场总览 |date=1999 |publisher=經濟日報出版社 |page=1658 |url=https://books.google.com/books?id=BoF4AAAAIAAJ&q=%E6%AD%A3%E5%BE%B7%E7%9A%87%E5%B8%9D+%221521%E5%B9%B44%E6%9C%8820%E6%97%A5%22 |access-date=27 July 2023 |language=zh}}
  • April 24 – Spanish rebels (executed)
  • Juan López de Padilla
  • Juan Bravo
  • Francisco Maldonado
  • April 27 – Ferdinand Magellan, Portuguese explorer (b. 1480){{cite book|author1=Deborah Wei|author2=Rachael Kamel|title=Resistance in Paradise: Rethinking 100 Years of U.S. Involvement in the Caribbean and the Pacific|url=https://books.google.com/books?id=i6F6AAAAMAAJ|year=1998|publisher=American Friends Service Committee|isbn=978-0-910082-33-4|page=15}}
  • April 28 – Suzanne, Duchess of Bourbon (b. 1491){{cite book |last1=La-Mure |first1=Jean Marie de |title=Histoire des ducs de Bourbon et des comtes de Forez: en forme d'annales sur preuves authentiques |date=1868 |publisher=Potier |page=564 |url=https://books.google.com/books?id=G2OE0vOGV9YC&dq=Suzanne+de+Bourbon+%2228+avril+1521%22&pg=PA564 |access-date=27 July 2023 |language=fr}}
  • May 10 – Sebastian Brant, German humanist and satirist (b. 1457){{cite book|author1=Max Reinhart|author2=James N. Hardin|title=German Writers of the Renaissance and Reformation, 1280-1580|url=https://books.google.com/books?id=qcwUAQAAIAAJ|year=1997|publisher=Gale Research|isbn=978-0-7876-1069-2|page=21}}
  • May 17 – Edward Stafford, 3rd Duke of Buckingham (executed) (b. 1478)
  • June 15 – Tamás Bakócz, Hungarian Catholic cardinal and statesman (b. 1442){{cite book |last1=Herbermann |first1=Charles George |title=The Catholic Encyclopedia |date=1913 |volume=2|publisher=Encyclopedia Press |page=214 |url=https://books.google.com/books?id=LwIjAQAAIAAJ&dq=Tam%C3%A1s+Bak%C3%B3cz+%2215+june+1521%22&pg=PA214 |access-date=27 July 2023 |language=en}}
  • June 22 – Leonardo Loredan, Doge of Venice (b. 1436){{cite book |last1=Cappelletti |first1=Giuseppe |title=Storia della repubblica di Venezia dal suo principio sino al giorno d'oggi |date=1852 |volume=8,9|publisher=G. Antenelli |page=33 |url=https://books.google.com/books?id=LlJKAAAAYAAJ&dq=Leonardo+Loredan+%2222+giugno+1521%22&pg=PA33 |access-date=27 July 2023 |language=it}}
  • July – Juan Ponce de León, Spanish conquistador (b. 1460){{cite book |last1=Slavicek |first1=Louise Chipley |title=Juan Ponce de León |date=2009 |publisher=Infobase Publishing |isbn=978-1-4381-0684-7 |page=87 |url=https://books.google.com/books?id=qNUPY1CGZ1MC&dq=Juan+Ponce+de+Le%C3%B3n+%22july+1521%22&pg=PA87 |access-date=27 July 2023 |language=en}}
  • July 9 – Raffaele Riario, Italian cardinal (b. 1461){{cite web |title=The Cardinals of the Holy Roman Church - Biographical Dictionary - Consistory of December 10, 1477 |url=https://cardinals.fiu.edu/bios1477.htm#Sansoni |website=cardinals.fiu.edu |access-date=27 July 2023}}
  • August 27 – Josquin des Prez, Flemish composer (b. c. 1450){{cite book |last1=Elders |first1=Willem |title=Josquin Des Prez and His Musical Legacy: An Introductory Guide |date=2013 |publisher=Leuven University Press |isbn=978-90-5867-941-3 |page=17 |url=https://books.google.com/books?id=dZNMAQAAQBAJ&dq=Josquin+des+Prez+%2227+august+1521%22&pg=PA17 |access-date=27 July 2023 |language=en}}
  • September 12 – In the Italian War, the Holy Roman Empire abandons its siege of the French-controlled city of Parma after 17 days.{{cite book |last1=Mallett |first1=Michael |last2=Shaw |first2=Christine |title=The Italian Wars: 1494–1559 |date=2012 |publisher=Pearson Education Limited |location=Harlow |page=141 |isbn=978-0-582-05758-6}}
  • September 15 –
  • Gazi Husrev Bey replaces Bali-beg Jahjapašić as the Ottoman Governor of Bosnia.
  • Teodosie becomes the new Voivode of Wallachia, at the capital, Targoviste, now in Romania.
  • October 7 – Margaret of Anhalt-Köthen, Princess of Anhalt by birth, Duchess consort of Saxony (b. 1494){{cite book |last1=Kohnle |first1=Armin |last2=Rudersdorf |first2=Manfred |title=Briefe und Akten zur Kirchenpolitik Friedrichs des Weisen und Johanns...: Band 2: 1518–1522. Bearbeitet von Stefan Michel, Beate Kusche, Ulrike Ludwig, Konstantin Enge, Dagmar Blaha und Alexander Bartmuß unter Mitarbeit von Saskia Jähnigen und Steven Bickel |date=28 June 2022 |publisher=Evangelische Verlagsanstalt |isbn=978-3-374-07173-9 |page=20 |url=https://books.google.com/books?id=3zpxEAAAQBAJ&dq=Margarete+von+Anhalt+%227+oktober+1521%22&pg=PA20 |access-date=27 July 2023 |language=de}}
  • October 22 – Edward Poynings, Lord Deputy to King Henry VII of England (b. 1459){{cite ODNB |title=Poynings, Sir Edward|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-22683|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/22683}}
  • October 24 – Robert Fayrfax, English Renaissance composer (b. 1464){{cite book |last1=Fayrfax |first1=Robert |title=Sacred Music from the Lambeth Choirbook |date=1 January 1985 |publisher=A-R Editions, Inc. |isbn=978-0-89579-150-4 |page=viii |url=https://books.google.com/books?id=-StRhNWLgtUC&dq=Robert+Fayrfax+%2224+october+1521%22&pg=PR8 |access-date=27 July 2023 |language=en}}
  • November 2 – Margaret of Lorraine, French Duchess of Alençon, Roman Catholic nun and blessed (b. 1463){{cite book |last1=Laurent |first1=Eugène |title=Histoire de Marguerite de Lorraine, Duchesse d'Alençon, bisaïeule de Henri IV., etc |date=1854 |publisher=Barbier |page=306 |url=https://books.google.com/books?id=SN9ZAAAAcAAJ&q=%222%20novembre%201521%22 |access-date=27 July 2023 |language=fr}}
  • December 1 – Pope Leo X (b. 1475){{cite web |title=Leo X {{!}} pope |url=https://www.britannica.com/biography/Leo-X |website=Encyclopedia Britannica |access-date=1 December 2020 |language=en}}
  • December 13 – King Manuel I of Portugal (b. 1469){{cite book |last1=Costa |first1=António Leite da |title=História de Portugal |date=4 November 2019 |publisher=Leya |isbn=978-972-20-6863-5 |page=109 |url=https://books.google.com/books?id=QOC_DwAAQBAJ&dq=Manuel+I+de+Portugal+%2213+de+dezembro+de+1521%22&pg=PA109 |access-date=27 July 2023 |language=pt-PT}}
  • December 21 – Domenico Spadafora, Italian Roman Catholic priest and blessed (b. 1450){{cite book |last1=Brigliadori |first1=Egidio |last2=Pasquini |first2=Agostino |title=Religiosità in Valconca: vicende e figure |date=2000 |publisher=Silvana |isbn=978-88-8215-266-6 |page=122 |url=https://books.google.com/books?id=4sYRAQAAIAAJ&q=%20%2221%20dicembre%201521%22 |access-date=27 July 2023 |language=it}}

File:Ferdinand Magellan.jpg|March–April: Ferdinand Magellan's voyage around the world.

File:Martin Luther.jpg|May 25: Martin Luther outlawed.

File:Hans Maler, Kunsthistorisches Museum Wien, Gemäldegalerie - Bildnis eines bartlosen Mannes - GG 884 - Kunsthistorisches Museum.jpg|Hans Maler zu Schwaz, Portrait of a beardless man with the inscription:
"ALS MAN. 1521. ZALT. WAS. ICH. 33. IAR ALT"
(mutatis mutandis to English: "as we had in 1521, I was 33 years old)

File:Lorenzo Lotto - Christ Taking Leave of his Mother - WGA13674.jpg|Lorenzo Lotto, Christ Taking Leave of His Mother

References

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