C-type lectin

{{Pfam box

| Symbol = Lectin_C

| Name = Lectin C-type domain

| image = PDB 1jzn EBI.jpg

| width =

| caption = Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.{{cite journal |vauthors=Walker JR, Nagar B, Young NM, Hirama T, Rini JM |title=X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure |journal=Biochemistry |volume=43 |issue=13 |pages=3783–92 |date=April 2004 |pmid=15049685 |doi=10.1021/bi035871a }}{{cite journal | vauthors = Mahla RS, Reddy MC, Prasad DV, Kumar H | title = Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology | journal = Frontiers in Immunology | volume = 4 | pages = 248 | date = September 2013 | pmid = 24032031 | pmc = 3759294 | doi = 10.3389/fimmu.2013.00248 | doi-access = free }}

| Pfam= PF00059

| InterPro= IPR001304

| SMART= CLECT

| Prosite = PS50041

| SCOP = 2msb

| TCDB =

| OPM family=

| OPM protein=

| CDD = cd00037

| PDB=

| Membranome family =

}}

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin.{{cite journal |vauthors=Zelensky AN, Gready JE |title=The C-type lectin-like domain superfamily |journal=FEBS J. |volume=272 |issue=24 |pages=6179–217 |date=December 2005 |pmid=16336259 |doi=10.1111/j.1742-4658.2005.05031.x |s2cid=7084402 }} The C-type designation is from their requirement for calcium for binding.{{MeshName|C-Type+Lectin}} Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.{{cite journal |author=Drickamer K |title=C-type lectin-like domains |journal=Curr. Opin. Struct. Biol. |volume=9 |issue=5 |pages=585–90 |date=October 1999 |pmid=10508765 |doi= 10.1016/S0959-440X(99)00009-3}}{{cite journal |vauthors=Cambi A, Figdor C |title=Necrosis: C-type lectins sense cell death |journal=Curr. Biol. |volume=19 |issue=9 |pages=R375–8 |date=May 2009 |pmid=19439262 |doi=10.1016/j.cub.2009.03.032 |s2cid=17409821 |doi-access=free |bibcode=2009CBio...19.R375C }}