The 7 general serotonin receptor classes include a total of 14 known serotonin receptors.[{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn = 9780071481274 | page = 4 | edition = 2nd |quote = Similarly, little is known about which of serotonin's 14 known receptors must be activated to achieve an antidepressant response. }}] The 15th receptor 5-HT1P has been distinguished on the basis of functional and radioligand binding studies, its existence has never been definitely affirmed or refuted.[{{Cite book | vauthors = Brady ST |title=Basic Neurochemistry - Principles of Molecular, Cellular and Medical Neurobiology |publisher=USA: Elsevier |year=2012 |isbn=978-0-12-374947-5 |edition=8th |location= Waltham, MA |pages=320–321}}][{{cite journal | vauthors = Mitchell NA, Pepperell E, Ociepka S, Brown JD, Witherington J, Tuladhar B, Sanger GJ, Lee K, Cellek S | display-authors = 6 | title = 5-hydroxyindalpine, an agonist at the putative 5-HT receptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon | journal = Neurogastroenterology and Motility | volume = 21 | issue = 7 | pages = 760–e48 | date = July 2009 | pmid = 19309442 | doi = 10.1111/j.1365-2982.2009.01275.x | s2cid = 9532359 }}] The specific types have been characterized as follows:[{{cite web | url = http://www.acnp.org/g4/GN401000039/Ch039.html | title = Serotonin Receptor Subtypes and Ligands | access-date = 2008-04-11 |vauthors=Glennon RA, Dukat M, Westkaemper RB | date = 2000-01-01 | publisher = American College of Neurophyscopharmacology | archive-url= https://web.archive.org/web/20080421160353/http://www.acnp.org/g4/GN401000039/Ch039.html| archive-date= 21 April 2008 | url-status= live}}][{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1288 | title = 5-Hydroxytryptamine Receptors | access-date = 2008-04-11 | work = IUPHAR Receptor Database | publisher = International Union of Basic and Clinical Pharmacology }}][{{cite journal | vauthors = Wesołowska A | title = In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors | journal = Polish Journal of Pharmacology | volume = 54 | issue = 4 | pages = 327–341 | year = 2002 | pmid = 12523486 | url = http://www.if-pan.krakow.pl/pjp/pdf/2002/4_327.pdf }}]
| class="wikitable mw-collapsible"
!colspan=13|Information on serotonin receptors (human isoforms if nothing else is stated) |
| rowspan=2| Receptor
!rowspan=2| First cloned – PDB entries
!rowspan=2| Gene(s)
!colspan=6| Distribution
!rowspan=2| Function
!rowspan=2| Agonists
!rowspan=2| Antagonists
!rowspan=2| Uses of drugs that act on this receptor |
|---|
| Blood vessels
! CNS
! GI Tract
! Platelets
! PNS
! Smooth Muscle |
|---|
| 5-HT1A
|1987 –
60px
|
| {{Yes}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
- Addiction
[{{cite journal | vauthors = Tomkins DM, Higgins GA, Sellers EM | title = Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake | journal = Psychopharmacology | volume = 115 | issue = 1–2 | pages = 173–179 | date = June 1994 | pmid = 7862892 | doi = 10.1007/BF02244769 | s2cid = 38012716 }}][{{cite journal | vauthors = Müller CP, Carey RJ, Huston JP, De Souza Silva MA | title = Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors | journal = Progress in Neurobiology | volume = 81 | issue = 3 | pages = 133–178 | date = February 2007 | pmid = 17316955 | doi = 10.1016/j.pneurobio.2007.01.001 | s2cid = 42788995 }}][{{cite journal | vauthors = Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP | title = Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects | journal = Brain Research | volume = 1034 | issue = 1–2 | pages = 162–171 | date = February 2005 | pmid = 15713268 | doi = 10.1016/j.brainres.2004.12.012 | s2cid = 28356741 }}]
- Aggression
[{{cite journal | vauthors = de Boer SF, Koolhaas JM | title = 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis | journal = European Journal of Pharmacology | volume = 526 | issue = 1–3 | pages = 125–139 | date = December 2005 | pmid = 16310183 | doi = 10.1016/j.ejphar.2005.09.065 }}]
- Anxiety
[{{cite journal | vauthors = Parks CL, Robinson PS, Sibille E, Shenk T, Toth M | title = Increased anxiety of mice lacking the serotonin1A receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 18 | pages = 10734–10739 | date = September 1998 | pmid = 9724773 | pmc = 27964 | doi = 10.1073/pnas.95.18.10734 | doi-access = free | bibcode = 1998PNAS...9510734P }}]
- Appetite
[{{cite journal | vauthors = Ebenezer IS, Arkle MJ, Tite RM | title = 8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors | journal = Methods and Findings in Experimental and Clinical Pharmacology | volume = 29 | issue = 4 | pages = 269–272 | date = May 2007 | pmid = 17609739 | doi = 10.1358/mf.2007.29.4.1075362 }}]
- Autoreceptor
- Blood Pressure
[{{cite journal | vauthors = Wouters W, Tulp MT, Bevan P | title = Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors | journal = European Journal of Pharmacology | volume = 149 | issue = 3 | pages = 213–223 | date = May 1988 | pmid = 2842163 | doi = 10.1016/0014-2999(88)90651-6 }}][{{cite journal | vauthors = Horiuchi J, McDowall LM, Dampney RA | title = Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation | journal = Autonomic Neuroscience | volume = 142 | issue = 1–2 | pages = 71–76 | date = November 2008 | pmid = 18667366 | doi = 10.1016/j.autneu.2008.06.004 | s2cid = 20878941 }}]
- Cardiovascular Function
[{{cite journal | vauthors = Nalivaiko E, Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 289 | issue = 2 | pages = R596–R604 | date = August 2005 | pmid = 15802554 | doi = 10.1152/ajpregu.00845.2004 | s2cid = 17426759 }}]
- Emesis
[{{cite journal | vauthors = Lucot JB | title = Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin | journal = European Journal of Pharmacology | volume = 253 | issue = 1–2 | pages = 53–60 | date = February 1994 | pmid = 8013549 | doi = 10.1016/0014-2999(94)90756-0 }}]
- Heart Rate
- Impulsivity
[{{cite journal | vauthors = Winstanley CA, Theobald DE, Dalley JW, Robbins TW | title = Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders | journal = Neuropsychopharmacology | volume = 30 | issue = 4 | pages = 669–682 | date = April 2005 | pmid = 15688093 | doi = 10.1038/sj.npp.1300610 | doi-access = free }}]
- Memory
[{{cite journal | vauthors = Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O | display-authors = 6 | title = The role of 5-HT(1A) receptors in learning and memory | journal = Behavioural Brain Research | volume = 195 | issue = 1 | pages = 54–77 | date = December 2008 | pmid = 18394726 | doi = 10.1016/j.bbr.2008.02.023 | s2cid = 140205386 }}][{{cite journal | vauthors = Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K | display-authors = 6 | title = Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory | journal = The American Journal of Psychiatry | volume = 160 | issue = 2 | pages = 334–340 | date = February 2003 | pmid = 12562581 | doi = 10.1176/appi.ajp.160.2.334 }}]
- Mood
[{{cite journal | vauthors = Kennett GA, Dourish CT, Curzon G | title = Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression | journal = European Journal of Pharmacology | volume = 134 | issue = 3 | pages = 265–274 | date = February 1987 | pmid = 2883013 | doi = 10.1016/0014-2999(87)90357-8 }}]
- Nausea
- Nociception
[{{cite journal | vauthors = Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC | title = Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain | journal = Pharmacology | volume = 67 | issue = 4 | pages = 182–194 | date = April 2003 | pmid = 12595749 | doi = 10.1159/000068404 | s2cid = 25882138 }}]
- Penile Erection
[{{cite journal | vauthors = Millan MJ, Perrin-Monneyron S | title = Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors | journal = European Journal of Pharmacology | volume = 321 | issue = 3 | pages = R11–R13 | date = March 1997 | pmid = 9085055 | doi = 10.1016/S0014-2999(97)00050-2 }}]
- Pupil Dilation
[{{cite journal | vauthors = Prow MR, Martin KF, Heal DJ | title = 8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation | journal = European Journal of Pharmacology | volume = 317 | issue = 1 | pages = 21–28 | date = December 1996 | pmid = 8982715 | doi = 10.1016/S0014-2999(96)00693-0 }}]
- Respiration
[{{cite journal | vauthors = Meyer LC, Fuller A, Mitchell D | title = Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 290 | issue = 2 | pages = R405–R413 | date = February 2006 | pmid = 16166206 | doi = 10.1152/ajpregu.00440.2005 | s2cid = 224414 }}]
- Sexual Behavior
[{{cite journal | vauthors = Popova NK, Amstislavskaya TG | title = Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice | journal = Psychoneuroendocrinology | volume = 27 | issue = 5 | pages = 609–618 | date = July 2002 | pmid = 11965359 | doi = 10.1016/S0306-4530(01)00097-X | s2cid = 25269315 }}]
- Sleep
[{{cite journal | vauthors = Monti JM, Jantos H | title = Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat | journal = Journal of Sleep Research | volume = 1 | issue = 3 | pages = 169–175 | date = September 1992 | pmid = 10607047 | doi = 10.1111/j.1365-2869.1992.tb00033.x | doi-access = free }}]
- Sociability
[{{cite journal | vauthors = Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS | title = A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy") | journal = Neuroscience | volume = 146 | issue = 2 | pages = 509–514 | date = May 2007 | pmid = 17383105 | doi = 10.1016/j.neuroscience.2007.02.032 | s2cid = 15617471 }}]
- Thermoregulation
[{{cite journal | vauthors = Gudelsky GA, Koenig JI, Meltzer HY | title = Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors | journal = Neuropharmacology | volume = 25 | issue = 12 | pages = 1307–1313 | date = December 1986 | pmid = 2951611 | doi = 10.1016/0028-3908(86)90101-2 | s2cid = 2547042 }}]
- Vasoconstriction
[{{cite journal | vauthors = Ootsuka Y, Blessing WW | title = Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits | journal = Brain Research | volume = 1073-1074 | pages = 252–261 | date = February 2006 | pmid = 16455061 | doi = 10.1016/j.brainres.2005.12.031 | s2cid = 23178233 }}]
|
Selective (for 5-HT1A over other 5-HT receptors)
Nonselective
- 5-CT (potent – Ki = 250 ± 50 pM)
- 8-OH-DPAT (potent)
- Aripiprazole (atypical antipsychotic)
- Asenapine (atypical antipsychotic)
- Buspirone
[[http://pharmacologycorner.com/serotonin-5ht-receptors-agonists-antagonist/ Pharmacology Corner > Serotonin (5-HT): receptors, agonists and antagonists] By Flavio Guzmán, M.D. on 9/08/09] (partial agonist)
- Vortioxetine (high-efficacy partial agonist)
["BRINTELLIX (vortioxetine) tablets for oral use. Full Prescribing Information, Section 12.2 (Pharmacodynamics)." Takeda Pharmaceuticals America Inc. and Lundbeck, 2013. Revised September 2013. [http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI] {{Webarchive|url=https://web.archive.org/web/20190918205248/http://general.takedapharm.com/content/file/pi.pdf?applicationcode=396066C6-E50F-4113-ABAD-54FE9525BF7E&filetypecode=BRINTELLIXPI|date=2019-09-18}}]
- Ziprasidone (partial agonist, Ki = 3.4 nM)
- Methylphenidate (weak agonist)
|
|
- Analgesics (agonists)
- Antidepressants (post-synaptic receptor agonists and pre-synaptic autoreceptor antagonists serve as antidepressants)
- Anxiolytics
[{{cite journal | vauthors = Cao BJ, Rodgers RJ | title = Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice | journal = Psychopharmacology | volume = 139 | issue = 3 | pages = 185–194 | date = October 1998 | pmid = 9784072 | doi = 10.1007/s002130050703 | s2cid = 9466299 }}] (agonist and antagonist) |
| 5-HT1B
|1992 –
|
| {{Yes}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
- Addiction
[{{cite journal | vauthors = Harrison AA, Parsons LH, Koob GF, Markou A | title = RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist | journal = Psychopharmacology | volume = 141 | issue = 3 | pages = 242–250 | date = January 1999 | pmid = 10027505 | doi = 10.1007/s002130050831 | s2cid = 19974789 }}]
- Aggression
- Anxiety
[{{cite journal | vauthors = Chojnacka-Wójcik E, Kłodzińska A, Tatarczyńska E | title = The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action | journal = The Journal of Pharmacy and Pharmacology | volume = 57 | issue = 2 | pages = 253–257 | date = February 2005 | pmid = 15720791 | doi = 10.1211/0022357055399 | s2cid = 20743875 }}][{{cite journal | vauthors = Lin D, Parsons LH | title = Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze | journal = Pharmacology, Biochemistry, and Behavior | volume = 71 | issue = 4 | pages = 581–587 | date = April 2002 | pmid = 11888549 | doi = 10.1016/S0091-3057(01)00712-2 | s2cid = 21610537 }}][{{cite journal | vauthors = Tatarczyńska E, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E | title = Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression | journal = Behavioural Pharmacology | volume = 15 | issue = 8 | pages = 523–534 | date = December 2004 | pmid = 15577451 | doi = 10.1097/00008877-200412000-00001 | s2cid = 6940756 }}]
- Autoreceptor
- Learning
[{{cite journal | vauthors = Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO | title = Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission | journal = Neuropharmacology | volume = 54 | issue = 7 | pages = 1041–1050 | date = June 2008 | pmid = 18394658 | doi = 10.1016/j.neuropharm.2008.02.007 | s2cid = 207223573 | hdl = 10616/40922 }}]
- Locomotion
[{{cite journal | vauthors = McCreary AC, Bankson MG, Cunningham KA | title = Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 290 | issue = 3 | pages = 965–973 | date = September 1999 | pmid = 10454466 }}]
- Memory
- Mood
- Penile Erection
- Sexual Behavior
- Vasoconstriction
|
|
|
|
| 5-HT1D
|1991 –
60px
|
| {{Yes}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
- Anxiety
[{{cite journal | vauthors = Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J | title = Anxiogenic effects of Sumatriptan in panic disorder: a double-blind, placebo-controlled study | journal = European Neuropsychopharmacology | volume = 15 | issue = 3 | pages = 279–282 | date = May 2005 | pmid = 15820416 | doi = 10.1016/j.euroneuro.2004.12.002 | s2cid = 8382188 }}][{{cite journal | vauthors = Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB | title = 5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex | journal = Neuroscience Letters | volume = 209 | issue = 3 | pages = 210–214 | date = May 1996 | pmid = 8736648 | doi = 10.1016/0304-3940(96)12637-9 | s2cid = 27376524 | author5-link = Bernhard Landwehrmeyer }}]
- Autoreceptor
- Locomotion
- Vasoconstriction
|
|
|
|
| 5-HT1E
|1992 –
60px
|
| {{Yes}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
|
|
|
|
| 5-HT1F
|1993 –
60px
|
| {{No}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
|
|
|
|
| 5-HT1P
|Not cloned
|
| {{No}}
| {{No}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
|
- Peristalsis
[{{cite journal | vauthors = Najjar SA, Hung LY, Margolis KG | title = Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation | journal = Comprehensive Physiology | volume = 13 | issue = 3 | pages = 4851–4868 | date = June 2023 | pmid = 37358510 | doi = 10.1002/cphy.c220024 | pmc = 10373054 | isbn = 9780470650714 }}]
|
- 5-OHIP
[{{cite journal | vauthors = Branchek TA, Mawe GM, Gershon MD | title = Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype (5-HT1P) with a selective agonist, 3H-5-hydroxyindalpine | journal = The Journal of Neuroscience | volume = 8 | issue = 7 | pages = 2582–2595 | date = July 1988 | pmid = 3249244 | pmc = 6569501 | doi = 10.1523/JNEUROSCI.08-07-02582.1988 }}]
- 2-Methyl-5-HT
[{{cite journal | vauthors = Mawe GM, Branchek TA, Gershon MD | title = Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 24 | pages = 9799–9803 | date = December 1986 | pmid = 3467338 | pmc = 387229 | doi = 10.1073/pnas.83.24.9799 | doi-access = free | bibcode = 1986PNAS...83.9799M }}]
- 5-BOHIP
[{{Cite journal |last1=Annaházi |first1=Anita |last2=Berger |first2=Thomas Erwin |last3=Demir |first3=Ihsan Ekin |last4=Zeller |first4=Florian |last5=Müller |first5=Michael |last6=Anneser |first6=Markus |last7=Skerra |first7=Arne |last8=Michel |first8=Klaus |last9=Schemann |first9=Michael |date=April 2022 |title=Metabotropic 5-HT receptor-mediated effects in the human submucous plexus |journal=Neurogastroenterology & Motility |language=en |volume=34 |issue=10 |pages=e14380 |doi=10.1111/nmo.14380 |pmid=35438222 |s2cid=248241342 |issn=1350-1925|doi-access=free }}]
|
|
|
| 5-HT2A
|1988
|
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
|
- Addiction (potentially modulating)
[{{cite journal | vauthors = Bubar MJ, Cunningham KA | title = Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence | journal = Current Topics in Medicinal Chemistry | volume = 6 | issue = 18 | pages = 1971–1985 | year = 2006 | pmid = 17017968 | doi = 10.2174/156802606778522131 }}]
- Anxiety
[{{cite journal | vauthors = Schreiber R, Melon C, De Vry J | title = The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test | journal = Psychopharmacology | volume = 135 | issue = 4 | pages = 383–391 | date = February 1998 | pmid = 9539263 | doi = 10.1007/s002130050526 | s2cid = 22677071 }}]
- Appetite
- Cognition
- Imagination
- Learning
- Memory
- Mood
- Perception
- Sexual Behavior
[{{cite journal | vauthors = Popova NK, Amstislavskaya TG | title = 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female | journal = Neuroendocrinology | volume = 76 | issue = 1 | pages = 28–34 | date = July 2002 | pmid = 12097814 | doi = 10.1159/000063681 | s2cid = 42319246 }}]
- Sleep
[{{cite journal | vauthors = Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J | display-authors = 6 | title = Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors | journal = The Journal of Neuroscience | volume = 25 | issue = 49 | pages = 11231–11238 | date = December 2005 | pmid = 16339018 | pmc = 6725907 | doi = 10.1523/JNEUROSCI.1724-05.2005 }}]
- Thermoregulation
[{{cite journal | vauthors = Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL | title = Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists | journal = Psychopharmacology | volume = 130 | issue = 2 | pages = 144–151 | date = March 1997 | pmid = 9106912 | doi = 10.1007/s002130050222 | s2cid = 22432569 | url = https://zenodo.org/record/1232625 }}]
- Vasoconstriction
[{{cite journal | vauthors = Blessing WW, Seaman B | title = 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats | journal = Neuroscience | volume = 117 | issue = 4 | pages = 939–948 | year = 2003 | pmid = 12654345 | doi = 10.1016/S0306-4522(02)00810-2 | s2cid = 53251590 }}]
|
- 25I-NBOMe (Full agonist)
- 2C-B
- 2C-I
- 5-MeO-DMT
- Aripiprazole (very weak partial agonist or antagonist)
- BZP
- Bufotenin
- DMT
- DOM
- Ergonovine
- Lisuride
- LSD
- Mescaline
- PNU-22394 (partial agonist)
[{{cite conference| vauthors = McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW |title= PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans |date= 2001 |conference= Society for Neuroscience |others= Presentation Number 309.2 | volume = 27 | issue = 309.2 |publisher= Society for Neuroscience Abstracts |url= http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Detail?AbsYear=2001&AbsID=4715 |page=TT-45| location=San Diego, CA |format= Online |access-date= 18 July 2014}}][{{cite journal | vauthors = Garfield AS, Heisler LK | title = Pharmacological targeting of the serotonergic system for the treatment of obesity | journal = The Journal of Physiology | volume = 587 | issue = 1 | pages = 49–60 | date = January 2009 | pmid = 19029184 | pmc = 2670022 | doi = 10.1113/jphysiol.2008.164152 }}][{{cite journal | vauthors = Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B | display-authors = 6 | title = Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties | journal = Journal of Medicinal Chemistry | volume = 56 | issue = 3 | pages = 1211–1227 | date = February 2013 | pmid = 23301527 | doi = 10.1021/jm301656h | citeseerx = 10.1.1.691.154 }}]
- Psilocin
- Psilocybin
- TFMPP (partial agonist or antagonist)
|
|
|
| 5-HT2B
|1992
|
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
|
- Anxiety
[{{cite journal | vauthors = Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP | title = Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety | journal = British Journal of Pharmacology | volume = 117 | issue = 7 | pages = 1443–1448 | date = April 1996 | pmid = 8730737 | pmc = 1909458 | doi = 10.1111/j.1476-5381.1996.tb15304.x }}][{{cite journal | vauthors = Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC | title = Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 601–608 | year = 1997 | pmid = 9225285 | doi = 10.1016/S0028-3908(97)00042-7 | s2cid = 41471226 }}][{{cite journal | vauthors = Kennett GA, Trail B, Bright F | title = Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated | journal = Neuropharmacology | volume = 37 | issue = 12 | pages = 1603–1610 | date = December 1998 | pmid = 9886683 | doi = 10.1016/S0028-3908(98)00115-4 | s2cid = 7310462 }}]
- Appetite
[{{cite journal | vauthors = Kennett GA, Ainsworth K, Trail B, Blackburn TP | title = BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats | journal = Neuropharmacology | volume = 36 | issue = 2 | pages = 233–239 | date = February 1997 | pmid = 9144661 | doi = 10.1016/S0028-3908(96)00171-2 | s2cid = 23583570 }}]
- Cardiovascular Function
- GI Motility
[{{cite journal | vauthors = Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS | display-authors = 6 | title = 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro | journal = British Journal of Pharmacology | volume = 135 | issue = 5 | pages = 1144–1151 | date = March 2002 | pmid = 11877320 | pmc = 1573235 | doi = 10.1038/sj.bjp.0704571 }}]
- Sleep
- Vasoconstriction
|
|
|
|
| 5-HT2C
|1988
|
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{Yes}}
|
- Addiction (potentially modulating)
- Anxiety
[{{cite journal | vauthors = Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP | display-authors = 6 | title = SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 609–620 | year = 1997 | pmid = 9225286 | doi = 10.1016/S0028-3908(97)00038-5 | s2cid = 23032157 }}][{{cite journal | vauthors = Millan MJ, Brocco M, Gobert A, Dekeyne A | title = Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade | journal = Psychopharmacology | volume = 177 | issue = 4 | pages = 448–458 | date = February 2005 | pmid = 15289999 | doi = 10.1007/s00213-004-1962-z | s2cid = 20866665 }}][{{cite journal | vauthors = Dekeyne A, Mannoury la Cour C, Gobert A, Brocco M, Lejeune F, Serres F, Sharp T, Daszuta A, Soumier A, Papp M, Rivet JM, Flik G, Cremers TI, Muller O, Lavielle G, Millan MJ | display-authors = 6 | title = S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models | journal = Psychopharmacology | volume = 199 | issue = 4 | pages = 549–568 | date = September 2008 | pmid = 18523738 | doi = 10.1007/s00213-008-1177-9 | s2cid = 25063495 }}]
- Appetite
- GI Motility
[{{cite journal | vauthors = Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A | display-authors = 6 | title = Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin | journal = Biological Psychiatry | volume = 65 | issue = 9 | pages = 748–759 | date = May 2009 | pmid = 19058784 | doi = 10.1016/j.biopsych.2008.10.031 | s2cid = 22053616 }}]
- Heteroreceptor for norepinephrine and dopamine
- Locomotion
- Mood
- Penile Erection
[{{cite journal | vauthors = Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S | title = 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists | journal = European Journal of Pharmacology | volume = 325 | issue = 1 | pages = 9–12 | date = April 1997 | pmid = 9151932 | doi = 10.1016/S0014-2999(97)89962-1 }}][{{cite journal | vauthors = Stancampiano R, Melis MR, Argiolas A | title = Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission | journal = European Journal of Pharmacology | volume = 261 | issue = 1–2 | pages = 149–155 | date = August 1994 | pmid = 8001637 | doi = 10.1016/0014-2999(94)90313-1 }}]
- Sexual Behavior
- Sleep
[{{cite journal | vauthors = Frank MG, Stryker MP, Tecott LH | title = Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor | journal = Neuropsychopharmacology | volume = 27 | issue = 5 | pages = 869–873 | date = November 2002 | pmid = 12431861 | pmc = 2452994 | doi = 10.1016/S0893-133X(02)00353-6 }}]
- Thermoregulation
- Vasoconstriction
|
- 2C-B (partial agonist)
[{{cite journal | vauthors = Villalobos CA, Bull P, Sáez P, Cassels BK, Huidobro-Toro JP | title = 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes | journal = British Journal of Pharmacology | volume = 141 | issue = 7 | pages = 1167–1174 | date = April 2004 | pmid = 15006903 | pmc = 1574890 | doi = 10.1038/sj.bjp.0705722 }}]
- A-372,159
- AL-38022A
- Aripiprazole
- Ergonovine
- Lorcaserin
- PNU-22394 (full agonist)
- Ro60-0175
- TFMPP
- Trazodone
[ (hypnotic][)]
- YM-348
|
|
|
| 5-HT3
|1993
|
- {{Gene|HTR3A}}
- {{Gene|HTR3B}}
- {{Gene|HTR3C}}
- {{Gene|HTR3D}}
- {{Gene|HTR3E}}
| {{No}}
| {{Yes}}
| {{Yes}}
| {{No}}
| {{Yes}}
| {{No}}
|
- Addiction
- Anxiety
- Emesis
- GI Motility
[{{cite journal | vauthors = Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M | display-authors = 6 | title = Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors | journal = Gastroenterology | volume = 128 | issue = 5 | pages = 1317–1326 | date = May 2005 | pmid = 15887114 | doi = 10.1053/j.gastro.2005.02.005 | doi-access = free }}]
- Learning
[{{cite journal | vauthors = Pitsikas N, Brambilla A, Borsini F | title = Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task | journal = Pharmacology, Biochemistry, and Behavior | volume = 47 | issue = 1 | pages = 95–99 | date = January 1994 | pmid = 8115433 | doi = 10.1016/0091-3057(94)90116-3 | s2cid = 21800364 }}]
- Memory
- Nausea
|
|
|
|
| 5-HT4
|1995
|
| {{No}}
| {{Yes}}
| {{Yes}}
| {{No}}
| {{Yes}}
| {{No}}
|
- Anxiety
[{{cite journal | vauthors = Smriga M, Torii K | title = L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 26 | pages = 15370–15375 | date = December 2003 | pmid = 14676321 | pmc = 307574 | doi = 10.1073/pnas.2436556100 | doi-access = free | bibcode = 2003PNAS..10015370S }}][{{cite journal | vauthors = Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ | title = Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 707–712 | year = 1997 | pmid = 9225297 | doi = 10.1016/S0028-3908(97)00037-3 | s2cid = 40341646 }}]
- Appetite
[{{cite journal | vauthors = Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V | display-authors = 6 | title = Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 41 | pages = 16335–16340 | date = October 2007 | pmid = 17913892 | pmc = 2042207 | doi = 10.1073/pnas.0701471104 | doi-access = free | bibcode = 2007PNAS..10416335J }}][{{cite journal | vauthors = Compan V, Charnay Y, Dusticier N, Daszuta A, Hen R, Bockaert J | title = [Feeding disorders in 5-HT4 receptor knockout mice] | journal = Journal de la Société de Biologie | volume = 198 | issue = 1 | pages = 37–49 | year = 2004 | pmid = 15146954 | doi = 10.1051/jbio/2004198010037 | s2cid = 90408378 }}]
- GI Motility
- Learning
[{{cite journal | vauthors = Meneses A, Hong E | title = Effects of 5-HT4 receptor agonists and antagonists in learning | journal = Pharmacology, Biochemistry, and Behavior | volume = 56 | issue = 3 | pages = 347–351 | date = March 1997 | pmid = 9077568 | doi = 10.1016/S0091-3057(96)00224-9 | s2cid = 11866740 }}][{{cite journal | vauthors = Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 689–696 | year = 1997 | pmid = 9225295 | doi = 10.1016/S0028-3908(97)00055-5 | s2cid = 46510811 }}]
- Memory
[{{cite journal | vauthors = Galeotti N, Ghelardini C, Bartolini A | title = Role of 5-HT4 receptors in the mouse passive avoidance test | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 286 | issue = 3 | pages = 1115–1121 | date = September 1998 | pmid = 9732367 }}]
- Mood
[{{cite journal | vauthors = Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G | display-authors = 6 | title = Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action | journal = Neuron | volume = 55 | issue = 5 | pages = 712–725 | date = September 2007 | pmid = 17785179 | doi = 10.1016/j.neuron.2007.07.041 | s2cid = 14558104 | doi-access = free }}][{{cite journal | vauthors = Duman RS | title = A silver bullet for the treatment of depression? | journal = Neuron | volume = 55 | issue = 5 | pages = 679–681 | date = September 2007 | pmid = 17785173 | doi = 10.1016/j.neuron.2007.08.011 | doi-access = free }}]
- Respiration
[{{cite journal | vauthors = Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW | title = 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia | journal = Science | volume = 301 | issue = 5630 | pages = 226–229 | date = July 2003 | pmid = 12855812 | doi = 10.1126/science.1084674 | s2cid = 13641423 | bibcode = 2003Sci...301..226M }}]
|
|
|
|
| 5-HT5A
|1994
- [https://www.rcsb.org/structure/7UM4 7UM4]
- [https://www.rcsb.org/structure/7UM5 7UM5]
- [https://www.rcsb.org/structure/7UM6 7UM6]
- [https://www.rcsb.org/structure/7UM7 7UM7]
|
| {{No}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
- Autoreceptor
- Locomotion
[{{cite journal | vauthors = Nelson DL | title = 5-HT5 receptors | journal = Current Drug Targets. CNS and Neurological Disorders | volume = 3 | issue = 1 | pages = 53–58 | date = February 2004 | pmid = 14965244 | doi = 10.2174/1568007043482606 }}]
- Sleep
[{{cite journal | vauthors = Dietz BM, Mahady GB, Pauli GF, Farnsworth NR | title = Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro | journal = Brain Research. Molecular Brain Research | volume = 138 | issue = 2 | pages = 191–197 | date = August 2005 | pmid = 15921820 | pmc = 5805132 | doi = 10.1016/j.molbrainres.2005.04.009 }}]
|
- 5-CT
- Ergotamine
- Lisuride (partial)
[{{cite journal | vauthors = Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | display-authors = 6 | title = Inactive and active state structures template selective tools for the human 5-HT5A receptor | journal = Nature Structural & Molecular Biology | volume = 29 | issue = 7 | pages = 677–687 | date = July 2022 | pmid = 35835867 | pmc = 9299520 | doi = 10.1038/s41594-022-00796-6 }}]
- Methylergometrine (full)
- Valerenic Acid (partial agonist)
|
|
|
| 5-HT5B
|1993
|
| {{No}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
Functions in rodents,
pseudogene in humans
|
|
|
|
| 5-HT6
|1993
|
| {{No}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
| {{No}}
|
- Anxiety
[{{cite journal | vauthors = Wesołowska A | title = The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors | journal = European Journal of Pharmacology | volume = 580 | issue = 3 | pages = 355–360 | date = February 2008 | pmid = 18096153 | doi = 10.1016/j.ejphar.2007.11.022 }}][{{cite journal | vauthors = Wesołowska A, Nikiforuk A | title = Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 52 | issue = 5 | pages = 1274–1283 | date = April 2007 | pmid = 17320917 | doi = 10.1016/j.neuropharm.2007.01.007 | s2cid = 22664564 }}]
- Cognition
[{{cite journal | vauthors = Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N | display-authors = 6 | title = SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models | journal = European Journal of Pharmacology | volume = 553 | issue = 1–3 | pages = 109–119 | date = December 2006 | pmid = 17069795 | doi = 10.1016/j.ejphar.2006.09.049 }}]
- Learning
[{{cite journal | vauthors = Perez-García G, Meneses A | title = Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task | journal = Pharmacology, Biochemistry, and Behavior | volume = 81 | issue = 3 | pages = 673–682 | date = July 2005 | pmid = 15964617 | doi = 10.1016/j.pbb.2005.05.005 | s2cid = 19789219 }}]
- Memory
- Mood
[{{cite journal | vauthors = Wesołowska A, Nikiforuk A | title = The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats | journal = European Journal of Pharmacology | volume = 582 | issue = 1–3 | pages = 88–93 | date = March 2008 | pmid = 18234190 | doi = 10.1016/j.ejphar.2007.12.013 }}]
|
- EMD-386,088
- EMDT
- WAY-181,187
- WAY-208,466
- E-6837
- N-(inden-5-yl)imidazothiazole-5-sulfonamide (43)
[{{cite journal | vauthors = Alcalde E, Mesquida N, López-Pérez S, Frigola J, Mercè R | title = Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists | journal = Journal of Medicinal Chemistry | volume = 52 | issue = 3 | pages = 675–87 | date = Feb 2009 | pmid = 19159187 | doi = 10.1021/jm8009469 }}]
|
|
|
| 5-HT7
|1993
|
| {{Yes}}
| {{Yes}}
| {{Yes}}
| {{No}}
| {{No}}
| {{No}}
|
- Anxiety
[{{cite journal | vauthors = Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG | title = 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern | journal = Biological Psychiatry | volume = 58 | issue = 10 | pages = 831–837 | date = November 2005 | pmid = 16018977 | doi = 10.1016/j.biopsych.2005.05.012 | s2cid = 10998014 }}][{{cite journal | vauthors = Wesołowska A, Nikiforuk A, Stachowicz K, Tatarczyńska E | title = Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 51 | issue = 3 | pages = 578–586 | date = September 2006 | pmid = 16828124 | doi = 10.1016/j.neuropharm.2006.04.017 | s2cid = 39928418 }}]
- Autoreceptor
- Memory
[{{cite journal | vauthors = Gasbarri A, Cifariello A, Pompili A, Meneses A | title = Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat | journal = Behavioural Brain Research | volume = 195 | issue = 1 | pages = 164–170 | date = December 2008 | pmid = 18308404 | doi = 10.1016/j.bbr.2007.12.020 | s2cid = 12910296 }}][{{cite journal | vauthors = Liy-Salmeron G, Meneses A | title = Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model | journal = Hippocampus | volume = 18 | issue = 9 | pages = 965–974 | year = 2008 | pmid = 18570192 | doi = 10.1002/hipo.20459 | s2cid = 20937527 }}]
- Mood
- Respiration
[{{cite journal | vauthors = Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C | display-authors = 6 | title = Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 321 | issue = 2 | pages = 690–698 | date = May 2007 | pmid = 17314195 | doi = 10.1124/jpet.107.119404 | s2cid = 14579645 }}]
- Sleep
[{{cite journal | vauthors = Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT | display-authors = 6 | title = SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats | journal = British Journal of Pharmacology | volume = 139 | issue = 4 | pages = 705–714 | date = June 2003 | pmid = 12812993 | pmc = 1573887 | doi = 10.1038/sj.bjp.0705290 }}]
- Thermoregulation
- Vasoconstriction
- Immunostimulation
[{{Cite journal |last1=León-Ponte |first1=Matilde |last2=Ahern |first2=Gerard P. |last3=O'Connell |first3=Peta J. |date=2007-04-15 |title=Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor |url=https://ashpublications.org/blood/article/109/8/3139/23709/Serotonin-provides-an-accessory-signal-to-enhance |journal=Blood |language=en |volume=109 |issue=8 |pages=3139–3146 |doi=10.1182/blood-2006-10-052787 |issn=0006-4971 |pmc=1852236 |pmid=17158224}}]
|
- 5-CT
- 8-OH-DPAT
- Aripiprazole (partial agonist)
[Davies MA, Sheffler DJ, Roth BL. Aripiprazole: A Novel Atypical Antipsychotic Drug With a Uniquely Robust Pharmacology. CNS Drug Reviews [Internet]. 2004 [cited 2013 Aug 4];10(4):317–36. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2004.tb00030.x/pdf]
- AS-19
- E-55888
|
|
|
