Template:Ion channel modulators
{{#invoke:navbox|navbox
| name = Ion channel modulators
| title = Ion channel modulators
| state = {{{state
| listclass = hlist
| groupstyle = text-align:center;
| group1 = Calcium
| list1 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = {{abbrlink|VDCCs|Voltage-dependent calcium channels}}
| list1 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- L-type-selective: Dihydropyridines: Amlodipine (+telmisartan and indapamide)
- Aranidipine
- Azelnidipine
- Barnidipine
- Clevidipine
- Cronidipine
- Darodipine
- Dexniguldipine
- Elgodipine
- Elnadipine
- Felodipine
- Flordipine
- Furnidipine
- Iganidipine
- Isradipine
- Lacidipine
- Lemildipine
- Lercanidipine
- Levamlodipine
- Levniguldipine
- Manidipine
- Mepirodipine
- Mesudipine
- Nicardipine
- Nifedipine
- Niguldipine
- Niludipine
- Nilvadipine
- Nimodipine
- Nisoldipine
- Nitrendipine
- Olradipine
- Oxodipine
- Palonidipine
- Pranidipine
- Ryodipine (riodipine)
- Sagandipine
- Sornidipine
- Teludipine
- Tiamdipine
- Trombodipine
- Vatanidipine; Diltiazem derivatives: Clentiazem
- Diltiazem
- Iprotiazem
- Nictiazem
- Siratiazem; Phenylalkylamines: Anipamil
- Dagapamil
- Devapamil
- Dexverapamil
- Emopamil
- Etripamil
- Falipamil
- Gallopamil
- Levemopamil
- Nexopamil
- Norverapamil
- Ronipamil
- Tiapamil
- Verapamil; Others: AH-1058
- Brinazarone
- Budiodarone
- Celivarone
- Cyproheptadine
- Dronedarone
- Fantofarone
- SR-33805
- Tetrahydropalmatine
- N-type-selective: ω-Conotoxins
- ω-Conotoxin GVIA
- Caroverine
- Huwentoxin XVI
- Leconotide (ω-conotoxin CVID)
- PD-173212
- Ralfinamide
- Safinamide
- Z160
- Ziconotide (ω-conotoxin MVIIA)
- Non-selective: ω-Agatoxin TK
- ω-Conotoxin MVIIC
- Benidipine
- Bepridil
- Cilnidipine
- Cinnarizine
- Dotarizine
- Efonidipine
- Flunarizine
- Lamotrigine
- Levetiracetam
- Lomerizine
- Loperamide
- Mibefradil
- NP078585
- Ruthenium red
- TROX-1
- α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin
- Arbaclofen
- Arbaclofen placarbil
- Atagabalin
- Baclofen
- Gabapentin
- Gabapentin enacarbil
- Imagabalin
- Mirogabalin
- PD-200,347
- PD-217,014
- PD-299,685
- Phenibut
- Pregabalin
- Others/unsorted: Bencyclane
- Berbamine
- Bevantolol
- Canadine
- Carboxyamidotriazole
- Cycleanine
- Dauricine
- Dimeditiapramine
- Diproteverine
- Enpiperate
- Eperisone
- Elpetrigine
- Ethadione
- Ethanol (alcohol)
- Ethosuximide
- Fasudil
- Fendiline
- Fostedil
- Imepitoin
- JTV-519
- Lidoflazine
- Magnesium
- Manoalide
- Mesuximide
- Monatepil
- Naftopidil
- Ochratoxin A
- Osthol
- Otilonium bromide
- Paramethadione
- Phensuximide
- Pinaverium bromide
- Prenylamine
- Rhynchophylline
- Sesamodil
- Silperisone
- Sipatrigine
- Terodiline
- Tetrandrine
- Tolperisone
- Trimethadione
- Valperinol
| group2 = Activators
| list2 =
}}
}}
| group2 = Potassium
| list2 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = {{abbrlink|VGKCs|Voltage-gated potassium channels}}
| list1 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- 3,4-Diaminopyridine (amifampridine)
- 4-Aminopyridine (fampridine/dalfampridine)
- Adekalant
- Almokalant
- Amiodarone
- Azimilide
- Bretylium
- Bunaftine
- Charybdotoxin
- Clamikalant
- Conotoxins
- Dalazatide
- Dendrotoxin
- Dofetilide
- Dronedarone
- E-4031
- Hanatoxin
- HgeTx1
- HsTx1
- Ibutilide
- Inakalant
- Kaliotoxin
- Linopirdine
- Lolitrem B
- Maurotoxin
- Nifekalant
- Notoxin
- Paxilline
- Pinokalant
- Quinidine
- ShK-186
- Sotalol
- Tedisamil
- Terikalant
- Tetraethylammonium
- Vernakalant
- hERG (KCNH2, Kv11.1)-specific: Ajmaline
- Amiodarone
- AmmTX3
- Astemizole
- Azaspiracid
- AZD1305
- Azimilide
- Bedaquiline
- BeKm-1
- BmTx3
- BRL-32872
- Chlorpromazine
- Cisapride
- Clarithromycin
- Darifenacin
- Dextropropoxyphene
- Diallyl trisulfide
- Domperidone
- E-4031
- Ergtoxins
- Erythromycin
- Gigactonine
- Haloperidol
- Ketoconazole
- Norpropoxyphene
- Orphenadrine
- Pimozide
- PNU-282,987
- Promethazine
- Quinidine
- Ranolazine
- Roxithromycin
- Sertindole
- Solifenacin
- Tamulotoxin
- Terodiline
- Terfenadine
- Thioridazine
- Tolterodine
- Vanoxerine
- Vernakalant
- KCNQ (Kv7)-specific: Linopirdine
- XE-991
- Spooky toxin (SsTx)
| group2 = Activators
| list2 =
- KCNQ (Kv7)-specific: Flupirtine
- Retigabine
}}
| group2 = {{abbrlink|IRKs|Inwardly rectifying potassium channel}}
| list2 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- {{abbrlink|KATP|ATP-sensitive potassium channel}}-specific: Acetohexamide
- Carbutamide
- Chlorpropamide
- Glibenclamide (glyburide)
- Glibornuride
- Glicaramide
- Gliclazide
- Glimepiride
- Glipizide
- Gliquidone
- Glisoxepide
- Glyclopyramide
- Glycyclamide
- Metahexamide
- Mitiglinide
- Nateglinide
- Repaglinide
- Tolazamide
- Tolbutamide
- {{abbrlink|GIRK|G protein-coupled inwardly rectifying potassium channel}}-specific: Barium
- Caramiphen
- Cloperastine
- Clozapine
- Dextromethorphan
- Ethosuximide
- Ifenprodil
- Tertiapin
- Tipepidine
| group2 = Activators
| list2 =
- {{abbrlink|KATP|ATP-sensitive potassium channel}}-specific: Aprikalim
- Bimakalim
- Cromakalim
- Diazoxide
- Emakalim
- Levcromakalim
- Mazokalim
- Minoxidil
- Minoxidil sulfate
- Naminidil
- Nicorandil
- Pinacidil
- Rilmakalim
- Sarakalim
- {{abbrlink|GIRK|G protein-coupled inwardly rectifying potassium channel}}-specific: ML-297 (VU0456810)
}}
| group3 = {{abbrlink|KCa|Calcium-activated potassium channel}}
| list3 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- BKCa-specific: Ethanol (alcohol)
- GAL-021
| group2 = Activators
| list2 =
- BKCa-specific: Flufenamic acid
- Meclofenamic acid
- Niflumic acid
- Nimesulide
- Rottlerin (mallotoxin)
- Tolfenamic acid
}}
| group4 = {{abbrlink|K2Ps|Tandem pore domain potassium channel}}
| list4 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
| group2 = Activators
| list2 =
}}
}}
| group3 = Sodium
| list3 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = {{abbrlink|VGSCs|Voltage-gated sodium channels}}
| list1 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- Antianginals: Ranolazine
- Antiarrhythmics (class I): Ajmaline
- Aprindine
- Disopyramide
- Dronedarone
- Encainide
- Flecainide
- Lidocaine
- Lorajmine
- Lorcainide
- Mexiletine
- Moricizine
- Pilsicainide
- Prajmaline
- Procainamide
- Propafenone
- Quinidine
- Sparteine
- Tocainide
- Anticonvulsants: Acetylpheneturide
- Carbamazepine
- Cenobamate
- Chlorphenacemide
- Elpetrigine
- Eslicarbazepine acetate
- Ethotoin
- Fosphenytoin
- Lamotrigine
- Lacosamide
- Licarbazepine
- Mephenytoin
- Oxcarbazepine
- Oxitriptyline
- Phenacemide
- Pheneturide
- Phenytoin
- Rufinamide
- Sipatrigine
- Topiramate
- Sodium valproate
- Valnoctamide
- Valproate pivoxil
- Valproate semisodium
- Valproic acid
- Valpromide
- Zonisamide
- Local anesthetics: pFBT
- Amylocaine
- Articaine
- Benzocaine
- Bupivacaine (Levobupivacaine, Ropivacaine)
- Butacaine
- Butamben
- Chloroprocaine
- Cinchocaine
- Cocaine
- Cyclomethycaine
- Dimethocaine
- Diphenhydramine
- Etidocaine
- Hexylcaine
- Iontocaine
- Lidocaine
- Mepivacaine
- Meprylcaine
- Metabutoxycaine
- Orthocaine
- Piperocaine
- Prilocaine
- Procaine
- Propoxycaine
- Proxymetacaine
- Risocaine
- Tetracaine
- Trimecaine
- Analgesics: AZD-3161
- DSP-2230
- Funapide
- GDC-0276
- NKTR-171
- PF-04531083
- PF-05089771
- Ralfinamide
- Raxatrigine
- RG7893 (GDC-0287)
- Suzetrigine
| group2 = Activators
| list2 =
- Aconitine
- Atracotoxins (ω-Atracotoxin, Robustoxin, Versutoxin)
- Batrachotoxin
- Ciguatoxins
- Grayanotoxins
- Poneratoxin
}}
| group2 = {{abbrlink|ENaC|Epithelial sodium channel}}
| list2 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
| group2 = Activators
| list2 =
}}
| group3 = {{abbrlink|ASICs|Acid-sensing ion channel}}
| list3 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
| group2 = Activators
| list2 =
}}
}}
| group4 = Chloride
| list4 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 ={{abbrlink|CaCCs|Calcium-activated chloride channel}}
| list1 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- Crofelemer
- DIDS
- Ethacrynic acid
- Flufenamic acid
- Fluoxetine
- Furosemide
- Glibenclamide
- Mefloquine
- Mibefradil
- Niflumic acid
| group2 = Activators
| list2 =
}}
| group2 = {{abbrlink|CFTR|Cystic fibrosis transmembrane conductance regulator}}
| list2 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
| group2 = Activators
| list2 =
- 1,7-Phenanthroline
- 1,10-Phenanthroline
- 4,7-Phenanthroline
- 7,8-Benzoquinoline
- Ivacaftor
- Phenanthridine
}}
| group3 = Unsorted
| list3 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = Blockers
| list1 =
- Bumetanide
- Flufenamic acid
- Meclofenamic acid
- Mefenamic acid
- Mepacrine
- Niflumic acid
- Talniflumate
- Tolfenamic acid
- Trifluoperazine
| group2 = Activators
| list2 =
}}
}}
| group5 = Others
| list5 = {{#invoke:navbox|navbox|child
| groupstyle = text-align:center;
| groupwidth = 5em;
| group1 = {{abbrlink|TRPs|Transient receptor potential channels}}
| list1 =
- See here instead.
| group2 = {{abbrlink|LGICs|Ligand gated ion channels}}
| list2 =
- See here instead.
}}
| below = See also: Receptor/signaling modulators • Transient receptor potential channel modulators
}}
{{collapsible option}}